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Synthesis and characterization of 3-aryl-3-[4-aryl-1,2,3-selenadiazol-5-yl]-2-phenyl-2-propenenitrile

“…4 Gidaspov et al studied the in vitro cytotoxic activity of 4-(2'-R 1 -4'-R 2 -1,3,5-triazin-6'-yl)-4,4-dinitrobutyric acid nitriles and methyl esters. 5 In the synthesis of heterocyclic compounds, the cyano group has the most fruitful utility. The reaction of nitriles with various amines leading to nitrogen heterocycles like benzimidazole, 6 imidazolines, 7 pyrrole derivatives 8 and the synthesis of amino heterocycles by Thorpe-Ziegler cyclization 9 are a few significant examples for its utility.…”

Synthesis and cytotoxic activity of trinitromethyl derivatives of 1,3,5-triazine

“…We have previously reported the synthesis of several new polynitromethyl derivatives of 1,3,5-triazine: substituted 1,3,5-triazinyldinitroethanes and 1,3,5-triazinyldinitroethanols [1], methyl esters and nitriles of substituted 1,3,5-triazinyldinitrobutanoic acids [2], and substituted halogendinitromethyl derivatives of 1,3,5-triazine [3]. Studies of their in vitro cytotoxic activity in relation to a wide spectrum of human tumor cell lines of different origins demonstrated the potential of further attempts to find possible antitumor substances within this series.…”

“…2,4-Dialkoxy deriva-1 Samara State Technical University. 2 Thus, in terms of their cytotoxic activities, trinitromethyl derivatives VI -VIII were entirely comparable with the most active chlorodinitromethyl derivatives of 1,3,5-triazine [3] and were significantly more active than derivatives of 1,3,5-triazinyldinitroethane, 1,3,5-triazinyldinitroethanol [1], and 1,3,5-triazinyldinitrobutyric acid [2].…”

Condensed tetrazolo-1,3,5-triazines. 4. Synthesis of salts of 5-aminotetrazolo[1,5-a]-1,3,5-triazin-7-one

“…5 The tetrazole ring in salts 2a,b is formed by closing the azide group at atom N(2) of the 1,3,5-triazine in the direction of the carbonyl group C(1)-O(13). The nature of the substituent at position 5 of the 1,3,5-triazine ring (the electron-withdrawing trinitromethyl group [3] or the electron-donating dialkylamino groups in compound 2a,b) does not affect the direction of cyclization during the azido-tetrazolo tautomeric conversion.…”

“…Maximum differences (0.04 Å and 3°) were observed in the 1,3,5-triazine ring about the substituent in position 5, apparently caused by the substituents (dimethylamino and dinitromethyl groups). Analysis of the bond lengths and bond angles in the 1,3,5-triazine and tetrazole rings of tetrazolo[1,5-a]-1,3,5-triazine systems in comparison with those in the structures of covalent 1,3,5-triazines [4], tetrazoles [5], and the sodium salt of tetrazole [6] showed that the whole conjugated cyclic system of the tetrazolo[1,5-a]-1,3,5-triazine was involved in the delocalization of the negative charge in the anion of compound 2a.…”