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New trinitromethyl derivatives of 1,3,5-triazine were synthesized with different substituents in positions 2 and 4. Data on the in vitro cytotoxic activity of the resulting compounds were obtained using a panel of 60 human tumor cell lines. The most active compounds were the 2,4-diamino-and 2-dimethylamino-4-azido derivatives. In terms of the general level of cytotoxicity, compounds of this series were more active than previously studied polynitromethyl derivatives of 1,3,5-triazine. 241 0091-150X/08/4205-0241

A series of 3 nitro 2 trifluoromethyl 2H chromenes was synthesized by the reactions of salicylaldehyde derivatives with 3,3,3 trifluoro 1 nitroprop 1 ene. Further transformations of the synthesized chromenes gave hitherto unknown 3 amino 2 trifluoromethylchromanes prom ising as precursors for the synthesis of fused heterocyclic systems. Cytotoxicity assay first revealed the pronounced activity of several 2 nitro 2 trifluoromethyl 2H chromenes against human tumor cell lines.

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Kondensation der Ribofuranose (I) mit den Nitropyrazolen (II) bei 150°C im Vakuum liefert Gemische der β‐Ribosid‐acetate (III) und (IV) (H‐NMR‐Spektren).