Alveolar echinococcosis of the brain in five patients

Takçı, Erhan; Sengul, Goksin; Akar, Ali; Uslu, Hakan; Alper, Fatih; Erdoğan, Fazlı; Aydin, İsmail Hakkı

doi:10.1016/j.jocn.2007.09.020

Cited by 11 publications

(5 citation statements)

References 9 publications

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“…Interestingly, we did notice the signi cant expression of VEGF-A, but there is no obvious increase of MVD in CAE lesions. In our present study, the MVD of CAE lesions had a similar expression with normal brain tissue and it was mainly centered on the external lesions, which corresponded to the characteristic of low/normal blood supply reported in previous surgical reports and imageology studies [8,31,32]. However, the MVD still showed a positive correlation with VEGF-A, in other words, the angiogenesis mediated by VEGF-A may be weakened or suppressed to some extent, on the plus side, this limited vascular growth would reduce the further cerebral spread of the Echinococcus multilocularis.…”

Section: Discussionsupporting

confidence: 84%

Expression of TNF-α, VEGF-A and microvessel density in cerebral alveolar echinococcosis and their correlation with perilesional brain edema

Wumier,

Abulizi,

et al. 2024

Preprint

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Alveolar echinococcosis (AE) is an infrequent zoonosis caused by Echinococcus multilocularis with a high degree of disability and mortality. Metastatic cerebral alveolar echinococcosis (CAE) is very rare and the lesions could lead to severe perilesional brain edema (PLBE) and subsequent uncontrollable intracranial hypertension. In this study, we sought to determine the expression of edema-associated factors in CAE lesions and their associations with PLBE. We retrospectively evaluated the clinical data of 18 CAE patients who received craniotomy. Severity of PLBE was described by edema index (EI). Archived specimens were processed for immunohistochemistry to detect tumor necrosis factor alpha (TNF-α), vascular endothelial growth factor A (VEGF-A) and microvessel density (MVD) in CAE lesions. Expression intensity of CAE lesions was quantified by integral optical density (IOD) or count and was compared to the control group. The results showed TNF-α and VEGF-A were significantly expressed in CAE lesions (p < 0.001), their levels were positively correlated with PLBE (TNF-α: r = 0.701, p = 0.001; VEGF-A: r = 0.803, p < 0.001). The MVD of CAE lesions had a similar expression with normal brain tissue, and it was positively correlated with PLBE and VEGF-A (PLBE: r = 0.849, p < 0.001; VEGF-A: r = 0.687, p = 0.002). In conclusion, we speculated the upregulation of TNF-α and VEGF-A induced the formation of PLBE. Besides, though there was no extra increase of MVD, it was still regulated by VEGF-A and provided a better anatomical basis for the formation of PLBE and further promoted it.

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Section: Discussionsupporting

confidence: 84%

Expression of TNF-α, VEGF-A and microvessel density in cerebral alveolar echinococcosis and their correlation with perilesional brain edema

Wumier,

Abulizi,

et al. 2024

Preprint

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“…), seizures and cranial nerve findings. [14] Immunofluorescence, indirect hemagglutination tests, ELISA and immunoelectrophoresis with antigenic extracts of EM are usually supportive laboratory tests for a diagnostic accuracy. [9] A solid, semisolid or multilocular cystic mass is a common finding on CT and MRI of EM.…”

Section: Discussionmentioning

confidence: 99%

Alveolar hydatid cyst mimicking cerebellar metastatic tumor

Özdöl¹,

Yildirim²,

Dağlıoğlu³

et al. 2011

Surg Neurol Int

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Background:Echinococcus multilocularis is a rare infestation in the world with a particularly increased incidence mainly in South America, Central Europe and Asia. Progression of alveolar Echinococcosis is more aggressive that can metastasize to lungs, brain and bones however brain involvement is usually rare with an incidence about 1%.Case Description:We report a 23-year-old man with a cerebellar Echinococcosis multilocularis mimicking a metastatic cerebellar tumor. Suboccipital craniotomy was performed for gross total removal of the tumor. Histopathological specimens confirmed the diagnosis of Echinococcosis multilocularis.Conclusion:Radical surgical excision should be recommended for single Echinococcosis multilocularis lesions particularly at infratentorial localization.

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“… 3 , 4 In Turkey and especially in the region we live in (Eastern Turkey), alveolar echinococcosis is an important life-threatening zoonotic disease. 5 , 6 In addition, due to the high human mobility recently, the disease has become an important health problem for other parts of Europe and Asia.…”

Section: Epidemiology and Life Cycle Of Echinococcus Multil...mentioning

confidence: 99%

Diagnostic and Management Perspectives in Alveolar Echinococcosis: Review of Literature

Aydin¹,

Yalçın²,

Karaman³

et al. 2023

Eurasian J Med

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Alveolar echinococcosis is a life-threatening zoonotic disease caused by Echinococcus multilocularis . The disease usually primarily involves the liver and shows tumor-like growth. Early diagnosis of alveolar echinococcosis is difficult because the disease is usually asymptomatic in the early stages. Untreated cases are fatal and result in death within 10 years of liver involvement. In the diagnosis of alveolar echinococcosis, the patient's medical history, radiological imaging findings, and serological and histopathological tests are used together. Radiological imaging methods are very important for early diagnosis and differential diagnosis of the disease. In this article, we wanted to review the diagnosis and treatment of alveolar echinococcosis and emphasize the importance of keeping it in mind, especially in cystic lesions of the liver, and the importance of early diagnosis of the disease.

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Alveolar echinococcosis of the brain in five patients

Cited by 11 publications

References 9 publications

Expression of TNF-α, VEGF-A and microvessel density in cerebral alveolar echinococcosis and their correlation with perilesional brain edema

Expression of TNF-α, VEGF-A and microvessel density in cerebral alveolar echinococcosis and their correlation with perilesional brain edema

Alveolar hydatid cyst mimicking cerebellar metastatic tumor

Diagnostic and Management Perspectives in Alveolar Echinococcosis: Review of Literature

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