Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation

Chung, Kuei-Pin; Cheng, Chih-Ning; Chen, Yi-Jung; Hsu, Chia-Lang; Huang, Yen-Lin; Hsieh, Min-Shu; Kuo, Han-Chun; Lin, Ya-Ting; Juan, Yi-Hsiu; Nakahira, Kiichi; Chen, Yen-Fu; Liu, Wei-Lun; Ruan, Sheng-Yuan; Chien, Jung-Yien; Plataki, Maria; Cloonan, Suzanne M.; Carmeliet, Peter; Choi, Augustine M. K.; Kuo, Ching-Hua; Yu, Chong-Jen

doi:10.1038/s41467-024-51683-1

Nat Commun

2024

DOI: 10.1038/s41467-024-51683-1

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Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation

Kuei-Pin Chung,

Chih-Ning Cheng,

Yi-Jung Chen

et al.

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Cited by 2 publications

References 70 publications

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Muco-adhesive chitosan-coated polyphenol nanoparticle for treatment of infectious acute pneumonia through sustained pulmonary delivery of polymyxin B

Fang,

Wang,

Zhang

et al. 2025

International Journal of Biological Macromolecules

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Muco-adhesive chitosan-coated polyphenol nanoparticle for treatment of infectious acute pneumonia through sustained pulmonary delivery of polymyxin B

Fang,

Wang,

Zhang

et al. 2025

International Journal of Biological Macromolecules

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Elucidating the Role of Sirtuin 3 in Mammalian Oocyte Aging

Kordowitzki

2024

Cells

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The field of reproductive biology has made significant progress in recent years, identifying specific molecular players that influence oocyte development and function. Among them, sirtuin 3 (SIRT3) has attracted particular attention for its central role in mediating mitochondrial function and cellular stress responses in oocytes. So far, studies have demonstrated that the knockdown of SIRT3 leads to a decrease in blastocyst formation and an increase in oxidative stress within an embryo, underscoring the importance of SIRT3 in maintaining the cellular redox balance critical for embryonic survival and growth. Furthermore, the literature reveals specific signaling pathways, such as the SIRT3- Glycogen synthase kinase-3 beta (GSK3β) deacetylation pathway, crucial for mitigating oxidative stress-related anomalies in oocyte meiosis, particularly under conditions like maternal diabetes. Overall, the emerging role of SIRT3 in regulating oocyte mitochondrial function and development highlights the critical importance of understanding the intricate connections between cellular metabolism, stress response pathways, and overall reproductive health and function. This knowledge could lead to the development of novel strategies to support oocyte quality and fertility, with far-reaching implications for assisted reproductive technologies and women’s healthcare. This commentary aims to provide an overview of the importance of SIRT3 in oocytes by synthesizing results from a multitude of studies. The aim is to elucidate the role of SIRT3 in oocyte development, maturation, and aging and to identify areas where further research is needed.

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Alveolar epithelial cells mitigate neutrophilic inflammation in lung injury through regulating mitochondrial fatty acid oxidation

Cited by 2 publications

References 70 publications

Muco-adhesive chitosan-coated polyphenol nanoparticle for treatment of infectious acute pneumonia through sustained pulmonary delivery of polymyxin B

Muco-adhesive chitosan-coated polyphenol nanoparticle for treatment of infectious acute pneumonia through sustained pulmonary delivery of polymyxin B

Elucidating the Role of Sirtuin 3 in Mammalian Oocyte Aging

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