2012
DOI: 10.1097/ccm.0b013e31822d718b
|View full text |Cite
|
Sign up to set email alerts
|

Alveolar fibrocyte percentage is an independent predictor of poor outcome in patients with acute lung injury*

Abstract: Fibrocytes are detectable in bronchoalveolar lavage during acute lung injury and acute respiratory distress syndrome. A bronchoalveolar lavage fibrocyte percentage >6% provides an additive prognostic value to clinical predictors and may be useful to identify patients with acute lung injury and acute respiratory distress syndrome at highest risk of an adverse outcome.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

2
40
0

Year Published

2013
2013
2021
2021

Publication Types

Select...
6
2

Relationship

0
8

Authors

Journals

citations
Cited by 38 publications
(42 citation statements)
references
References 8 publications
2
40
0
Order By: Relevance
“…They are present in the BAL fluid and blood of patients with IPF, and increased fibrocyte numbers predict exacerbations (14,16). Fibrocytes are also found in the BAL fluid of patients with ARDS, and are associated with increased mortality (17,18). CXCL12 is constitutively expressed in a number of tissues, and binds to the CXCR4 receptor on fibrocytes to promote migration (12,14,(35)(36)(37).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…They are present in the BAL fluid and blood of patients with IPF, and increased fibrocyte numbers predict exacerbations (14,16). Fibrocytes are also found in the BAL fluid of patients with ARDS, and are associated with increased mortality (17,18). CXCL12 is constitutively expressed in a number of tissues, and binds to the CXCR4 receptor on fibrocytes to promote migration (12,14,(35)(36)(37).…”
Section: Discussionmentioning
confidence: 99%
“…Fibrocytes are contained in the bronchoalveolar lavage (BAL) and blood of patients with idiopathic pulmonary fibrosis (IPF), and may predict exacerbations (14,16). Recently, fibrocytes were found in the BAL of patients with ARDS, and were associated with increased mortality (17,18). The mechanisms governing fibrocyte recruitment and activation in ALI remain unknown.…”
Section: Cd25mentioning
confidence: 99%
“…Fibroproliferation is an important process in ALI, which is considered to be the injury repair process for ALI.15 However, many reports have shown that excessive fibroproliferation induces fibrosis of the lung and causes the death of patients with ALI [21, 24]. In addition, another report showed that the alveolar fibrocyte level can act as an independent predictor of poor outcomes in patients with ALI [27]. Therefore, the function of fibrocytes in ALI needs to be further investigated in future studies.…”
Section: Discussionmentioning
confidence: 99%
“…Fibrocytes participate in bleomycin models of pulmonary fibrosis [26]. Fibrocytes exist in bronchoalveolar lavage fluid (BALF) and BAL blood of patients with IPF as well as the BALF of patients with ARDS, which increases mortality in ARDS patients [27]. As mentioned above, fibrocytes are closely associated with lung diseases and inflammation [16, 28].…”
Section: Introductionmentioning
confidence: 99%
“…The higher quantity of circulating fibrocytes indicated a poor prognosis in IPF 61 , and increased mortality in patients with acute respiratory distress syndrome (ARDS) 69 . The counts of circulating fibrocytes were significantly elevated in the blood of patients with stable IPF (2.72±0.34%) compared with healthy control subjects (1±0.12%).…”
Section: Clinical Pathogenic Significance Of Circulating Fibrocytementioning
confidence: 99%