Alveolar ridge dimensional changes following ridge preservation procedure with novel devices: part 3 – histological analysis in non‐human primate model

Su, Yingying; Tang, Jianxia; Min, Seiko; Guo, Lijia; Liu, Yitong; Xie, Yilin; Xiong, Jie; Wang, Songlin; Araújo, Maurício G.; Zadeh, Homayoun H.; Liu, Yi

doi:10.1111/clr.13010

Cited by 6 publications

(4 citation statements)

References 39 publications

(99 reference statements)

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“…[1][2][3] Previous animal studies reporting dimensional change have been performed in fresh extraction sockets. [4][5][6][7][8] However, if teeth with a severe inflammatory state are extracted, bone resorption may be more extensive and altered, 2 and alveolar bone destruction may influence the optimal placement of dental implants. 2 Thus, ridge preservation techniques have been performed to prevent alveolar dimensional change.…”

Section: Introductionmentioning

confidence: 99%

Biomodification of compromised extraction sockets using hyaluronic acid and rhBMP‐2: An experimental study in dogs

Kim

Amara

Park

et al. 2018

Journal of Periodontology

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Background This experimental study aims to evaluate the effect of hyaluronic acid on healing of infected extraction sockets compared with recombinant human bone morphogenetic protein‐2 (rhBMP‐2). Methods Both third and fourth mandibular premolars of six beagle dogs were hemisected, and the distal roots were extracted at baseline. Subsequently, combined endodontic‐periodontic lesions were induced at the remaining mesial roots. After 4 months, the mesial roots on both sides of the mandible were removed. Four sockets per dog were randomly allocated to four groups: Group 1, Control; Group 2, only absorbable collagen sponge (ACS: carrier); Group 3, 1% hyaluronic acid (HA) gel + ACS; and Group 4, rhBMP‐2 + ACS. After 3 months of healing, the dogs were euthanized for microcomputed tomography and histologic analysis. Results After the lesion induction period (4 months), communication between the periodontal lesion and endodontic periapical lesion was observed at all remaining mesial roots. Alveolar bone overgrowth was observed in groups 3 and 4, but bone volume density was not significantly different among all groups. At the crestal portion, mineralization, and osteocalcin expression were higher in groups 3 and 4 than in groups 1 and 2. Conclusion Treatment with HA can promote bone formation and improve the wound healing rate comparable to rhBMP‐2 in infected extraction sockets.

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Section: Introductionmentioning

confidence: 99%

Biomodification of compromised extraction sockets using hyaluronic acid and rhBMP‐2: An experimental study in dogs

Kim

Amara

Park

et al. 2018

Journal of Periodontology

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“…Numerous studies have demonstrated that significant bone resorption occurs as an inevitable biological event following tooth extraction without additional intervention [ 1 – 11 ]. The rates of loss of alveolar bone width and height in the first three months following extraction are approximately 0.25 mm and 0.2 mm, respectively [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Various biomaterials used for ridge preservation have been evaluated including autograft [ 18 , 19 ], allograft [ 20 ], xenograft [ 18 , 21 – 25 ], and alloplast [ 24 , 26 – 28 ]. These graft materials have been protected by different barrier devices, including resorbable membranes [ 20 , 29 , 30 ], nonresorbable membranes [ 31 ], autogenous soft tissue plugs [ 32 ], and extraction socket devices [ 7 – 11 ].…”

Section: Introductionmentioning

confidence: 99%

Functionalized Scaffold and Barrier Membrane with Anti‐BMP‐2 Monoclonal Antibodies for Alveolar Ridge Preservation in a Canine Model

Min

Kim

et al. 2020

BioMed Research International

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Introduction. The aim of this study was to investigate the ability of anti-bone morphogenetic protein 2 monoclonal antibody (anti-BMP-2 mAb) to functionalize scaffolds to mediate bone regeneration in a canine model. Materials and Methods. The mandibular right premolar 4 (PM4) was extracted in eight beagle dogs and grafted with anti-BMP-2 mAb+anorganic bovine bone mineral with 10% collagen (ABBM-C) and porcine bilayer native collagen membrane (CM). The ABBM-C and CM were functionalized with either anti-BMP-2 mAb (test group) or an isotype matched control mAb (control group). Animals were euthanized at 12 weeks for radiographic, histologic, and histomorphometric analyses. Outcomes were compared between groups. Results. 3D imaging using cone beam computed tomography (CBCT) revealed that sites treated with ABBM-C and CM functionalized with anti-BMP-2 mAb exhibited significantly more remaining bone width near the alveolar crest, as well as buccal bone height, compared with control groups. Histologic and histomorphometric analyses demonstrated that in anti-BMP-2 mAb-treated sites, total tissue volume was significantly higher in the coronal part of the alveolar bone crest compared with control sites. In anti-BMP-2 mAb-treated sites, bone formation was observed under the barrier membrane. Conclusion. Functionalization of the ABBM-C scaffold and CM appeared to have led to bone formation within healing alveolar bone sockets.

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“…Even if teeth with a severe inflammatory state are extracted, bone resorption may be more aggressive, and alveolar bone destruction may influence the perfect placement of the dental implant. (2)(3)(4) Xenogenous bone grafts (e.g., Bio-Oss ®) have long been used in the treatment of periodontal bone defects. Bovine-Derived Xenograft (BDX) (Bio-Oss®) has osteoconductive properties and high biocompatibility that undergoes chemical extraction process by which all organic components are removed maintaining the natural architecture of bone.…”

Section: Introductionmentioning

confidence: 99%

Bone Regeneration and Socket Preservation Using Bone Augmenting Materials (Histomorphometeric Study in Rabbits)

Khalil

Omar

2019

Egyptian Dental Journal

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Background:The ultimate goal of periodontal therapy is the regeneration of tissues destroyed by periodontal disease Fibronectin belongs to a group of high molecular weight glycoproteins that exist on cell surfaces. It is known to play a role in cell-to-cell and cell-to-substrate adhesion, as well as an essential role in osseointegration due to its capacity to make osteoblasts attach to the extracellular matrix(ECM) components. Combination of Fibronectin and commercially available bone grafts may hold a promising potential of enhanced bone regeneration.Objective: Comparison of the effect of fibronectin, Bovine-Derived Xenograft (BDX)and their combination for socket preservation through histologic and histomorphometric analysis.Material and Method: Thirty six clinically healthy adult New Zealand white male rabbits, were used in this study. The animals were equally divided into three groups; I-control group (defect was left empty as control), II-bio group (bio-oss was applied on the socket ) and III-( Bio Fibro group) bone and fibronectin group( socket was filled with Bovine-Derived Xenograft Bio-Oss® with fibronectin). At 4 and eight weeks the animals were sacrificed. Bone regeneration among the three groups was evaluated through histologic and histomorphometric analysis. Results:The most significant value of area percent of newly formed bone was observed in the (bone and fibronectin) group, then the fibronectin group, with the least amount recorded in the control group. The difference was extremely statistically significant (p<0.0001). The socket is almost filled with newly formed bone trabeculae with organized fibrous tissue in the fibronectin and bone group ( Bio Fibro group ) at eight weeks. Conclusion:Fibronectin is a useful biomaterial for the enhancement of bone formation. Combination of fibronectin and bovine graft seems to lead significantly to favorable bone regeneration and could be efficaciously used in the socket preservation.

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Alveolar ridge dimensional changes following ridge preservation procedure with novel devices: part 3 – histological analysis in non‐human primate model

Cited by 6 publications

References 39 publications

Biomodification of compromised extraction sockets using hyaluronic acid and rhBMP‐2: An experimental study in dogs

Biomodification of compromised extraction sockets using hyaluronic acid and rhBMP‐2: An experimental study in dogs

Functionalized Scaffold and Barrier Membrane with Anti‐BMP‐2 Monoclonal Antibodies for Alveolar Ridge Preservation in a Canine Model

Bone Regeneration and Socket Preservation Using Bone Augmenting Materials (Histomorphometeric Study in Rabbits)

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