“… 1 , 2 Immunohistochemical stains show that the giant cells are positive for vimentin and negative for cytokeratin, S-100 protein, neurofilament, and leukocyte common antigen, indicating these stellate giant cells in oral GCFs are of mesenchymal origin instead of epithelial, neurogenic, or hematogenous origin. 2 , 3 , 4 , 5 Oral GCFs can occur at any age. The mean age of the 24 Taiwanese patients with GCF is 29 years and approximately 60% of the lesions occur in the first three decades with the highest incidence being in the third decade.…”