Alveolar soft-part sarcoma of the masseter and mandibular ramus: Report of a case and review of the literature

Abstract

Alveolar soft-part sarcomas are clinically and morphologically distinct soft-tissue sarcomas, with an unknown histogenesis. When the tumors affect the region of the head and neck, they are often located in the orbit and tongue. We report a case of an alveolar soft-part sarcoma in the left masseter of a 28-year-old female. The patient had chronic pain and paresthesia of her left lower lip. Panoramic radiography and computed tomography showed a well-delimited radiolucent mass in the left ramus. An incisional biopsy was performed, and the sample submitted for histopathological study. The tumor showed positive periodic acid-Schiff diastase-resistant granules. Immunohistochemically, the tumor cells were diffusely positive for myoglobin, and focally positive for actin and desmin.

Alveolar soft-part sarcoma of the oral cavity: A review of literature

“…2,[20][21][22]25,27 SMA was found to be positive in 18 cases (85.71%) 9,14,20,23,26,27 and negative in 3 cases (14.28%). 12,13,25 Desmin (d-33) expression was positive in 18 cases (85.71%), 2,9,11,12,14,16,17,19,22,26,28 while negative in 3 (14.28%). 13,18,20 From the seven cases, five (71.42%) cases showed positivity (+) for MYOD1, 14,22,23,25,28,29 one (14.28%) case demonstrated strong positivity (++), while the remaining one (14.28%) showed negative expression.…”

“…While in our analysis, we have found out an age range of 1.5-64 years with a mean of 18.25 ± 15.243 years. There were 31 (41.9%) males 9,10,15,16,23,25,[27][28][29][31][32][33][34][35][36] and 43 (58.1%) females 2,3,5,8,[11][12][13][14][16][17][18][19][20][21]24,26,27,[36][37][38][39][40][41][42][43][44][45][46] in the review and male-tofemale ratio of 1:1.4 with female predilection. Gender predilection in our review is in accordance with Wang et al 30 and male-to-female ratio is in contrast with that of Fanburg-Smith et al 16 According to Kim et al, 36 most of the patients were from the second decade with slender female predilection.…”

“…Three cases (18.75%) showed S100 positivity (+), 12,17,20,27 while 13 cases (81.25%) showed negative S100 expression. 2,3,5,13,18,21,25,26,28,29 Out of the nine cases, one case (11.11%) showed positivity for cytokeratin (CK) (+), 27 while eight (88.88%) cases showed negative expression. 20,21,25,26 Argyris et al 25 had carried out immunohistochemical study on ASPS using TFE3 transcription factor and found positive expression (+) in accordance with the results found by Min et al 22 He also found positivity with diffuse cytoplasmic neuron-specific enolase (NSE), MYOD1, desmin, and CD68 similar to Min's findings, while Rodríguez-Velasco et al 5 found negativity for CD68.…”

Computed tomography, magnetic resonance imaging, and F-deoxyglucose positron emission computed tomography/computed tomography findings of alveolar soft part sarcoma with calcification in the thigh: A case report

“…ASPS is a distinct, malignant soft-tissue tumor characterized by a pseudoalveolar architecture associated with abundant sinusoidal vessels. Adolescents and young adults, aged 15–35 years with a male to female ratio of 1:2, are more likely to be affected[ 1 - 3 ]. ASPS often develops in the lower extremities for adults; however, the head and neck are more frequently involved in children[ 4 - 6 ].…”

“…Alveolar soft part sarcoma (ASPS) is an extremely rare malignant sarcoma, constituting less than 1% of all soft-tissue sarcomas[ 1 ]. ASPS was first described by Christopherson et al[ 2 ] in 1952, deriving its name from its histological appearance[ 1 - 3 ]. The most common locations of ASPS are the lower extremities, head, and neck[ 4 - 6 ].…”