Alveolar wound healing and ridge remodeling after tooth extraction in the rat: A histologic, radiographic, and histometric study

Guglielmotti, M.B.; Cabrini, R. L.

doi:10.1016/0278-2391(85)90257-5

Cited by 89 publications

(100 citation statements)

References 11 publications

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“…The alveolar bone neoformation propagates from the apical and lateral walls towards the center and the healing process culminates with the filling of the dental socket by trabecular bone. 11,12 Studies in rats have confirmed that maximal bone formation 13 and maximal bone mineral density 12 occur by the end of the second week after tooth extraction, the first period chosen for bone healing measurement in the present study.…”

Section: Discussionsupporting

confidence: 57%

Cola beverage consumption delays alveolar bone healing: a histometric study in rats

2010

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Epidemiological studies have suggested that cola beverage consumption may affect bone metabolism and increase bone fracture risk. Experimental evidence linking cola beverage consumption to deleterious effects on bone is lacking. Herein, we investigated whether cola beverage consumption from weaning to early puberty delays the rate of reparative bone formation inside the socket of an extracted tooth in rats. Twenty male Wistar rats received cola beverage (cola group) or tap water (control group) ad libitum from the age of 23 days until tooth extraction at 42 days and euthanasia 2 and 3 weeks later. The neoformed bone volume inside the alveolar socket was estimated in semi-serial longitudinal sections using a quantitative differential point-counting method. Histological examination suggested a decrease in the osteogenic process within the tooth sockets of rats from both cola groups, which had thinner and sparser new bone trabeculae. Histometric data confirmed that alveolar bone healing was significantly delayed in cola-fed rats at three weeks after tooth extraction (ANOVA, p = 0.0006, followed by Tukey's test, p < 0.01). Although the results of studies in rats cannot be extrapolated directly to human clinical dentistry, the present study provides evidence that cola beverage consumption negatively affect maxillary bone formation.

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Section: Discussionsupporting

confidence: 57%

Cola beverage consumption delays alveolar bone healing: a histometric study in rats

2010

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“…The reasons for third molar extraction are varied like pericoronitis, decay, risk of damage to adjacent teeth, cyst or tumor formation, or to facilitate orthodontic treatment [1]. The postextraction bone loss, a physiological phenomenon will take place with alveolar resorption and the subsequent formation of bone within the socket follows osteoblastic differentiation of osteoprogenitor cells [2][3][4]. This phenomenon continues for a period of weeks [4].…”

Section: Introductionmentioning

confidence: 99%

“…The postextraction bone loss, a physiological phenomenon will take place with alveolar resorption and the subsequent formation of bone within the socket follows osteoblastic differentiation of osteoprogenitor cells [2][3][4]. This phenomenon continues for a period of weeks [4]. However, studies have documented that the bone volume following extractions decreased by 50% within 12 months, and two-thirds of this resorption took place during the first 3 months after extraction [5,6].…”

Section: Introductionmentioning

confidence: 99%

Autogenous Demineralized Dentin Graft for Third Molar Socket Regeneration - A Case Report

Kabir¹,

Murata²,

Kusano³

et al. 2015

Dentistry

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of components is similar (mineral 70%, collagen 20%, body fluid 10% by weight). After demineralization, dentin matrix is mainly composed of predominantly type-I collagen (95%) and non-collagenous proteins including growth factors [13]. Growth factors identified in human dentin included insulin like growth factor I (IGF-I), skeletal growth factor/insulin like growth factor II (IGF-II), and transforming growth factor-β (TGF-β) [14]. Considering these reports, human tooth-derived demineralized dentin matrix (DDM) could be defined as acid-insoluble collagen with bone inducing molecules.The history of a bone-inducing research in dentin began with a report in 1967 that animal derived DDM induced bone formation in the intramuscular pockets [15]. Until now, several dentin studies have reported the osteoinductive potency of DDM and presence of BMP molecule in dentin matrix [16][17][18][19][20]. In addition, it was noted that DDM derived from human teeth, induced bone and cartilage independently in subcutaneous tissues of nude mice at 4 weeks after implantation [20,21]. As human tooth-derived DDM has been recycled as osteoinductive materials for local bone regeneration [20], therefore, this case report described the efficacy of autogenous DDM for bone regeneration in the extracted socket.The aim of this clinical report was to evaluate the feasibility of the autogenous DDM on new bone formation during the healing of the extracted socket after a period of 12 months. The observation of

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“…Wound healing chronology after tooth extraction (molars and incisors), which consists in several phases, has been examined by histological, radiological, immunohistochemistry 5,6 stereology (bone volumetry), and densitometry 3,4 , methods and by using of micro-camera to determine the volume fraction of histological components 7 .…”

Section: Introductionmentioning

confidence: 99%

“…The aim of this study is to analyse the process of healing of normal extraction wound and to determine the period of time it takes for the postextraction wound to completely heal [3][4][5][6][7] . The research is based on the literature available in electronic databases Pubmed/Medline 8 , Kobson 9 , Googlescholar 10 .…”

Section: Introductionmentioning

confidence: 99%

Healing of extraction wounds in an experimental model of rat

Stojanović¹,

Spasić²,

Tijanić³

2011

Acta stomatologica Naissi

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Uvod: Proces zarastanja rane nakon ekstrakcije zuba je sa velikom pažnjom istraživan kod nekoliko životinjskih vrsta pod normalnim i eksperimentalnim uslovima koji bi mogli ometati zarastanje. Hronologija zarastanja rane nakon ekstrakcije zuba -molara i inciziva se kod pacova odvija u nekoliko faza i ispitivana je histološkim, radiografskim, dezintrometrijskim, imunohistohemijskim i stereološkim(tačkasta volumetrija) metodama, kao i upotrebom mini kamere za određivanje volumenske frakcije histoloških komponenti UvodProces zarastanja rane nakon ekstrakcije zuba je sa velikom pažnjom istraživan kod nekoliko životinjskih vrsta pod normalnim i eksperimentalnim uslovima koji bi mogli ometati zarastanje.Pacovi imaju ukupno šesnaest zuba, osam u gornjoj i osam u donjoj vilici 1 . Od toga četiri duga, ostra inciziva, po dva u svakoj vilici. Incizivi su specijaliovani za glodanje i mogu se obnavljati tj. ponovo izrastati tokom zivota. Imaju jedan, dug koren sa širokim apikalnim otvorom. Kada bi izrastali bez trošenja-abrazije, incizivi bi bili lučno savijeni pod uglom od 86 stepeni. Stopa erupcije je kod odraslih pacova 2,2 mm nedeljno (0,31-0,32 mm dnevno), donji incizivi u proseku rastu 2,8 mm nedeljno (0,4 mm dnevno). Na taj način stari zub se zameni novim za nekih 40-50 dana, odnosno pacov nema inciziva starijih od 50 dana 1 .Molari kod pacova sluze za mlevenje hrane. Postoji ukupno dvanaest molara, po šest u svakoj vilici, sa svake strane po tri. Molari se ne obnavljaju, tj. kod pacova postoji samo jedan set molara u toku života, zbog toga se nazivaju monofiodonti. Molari imaju dva malo kraća korena, koji ne rastu 1 .Pacovi nemaju ni očnjake ni premolare. Na mestima gde bi trebalo da budu lateralni sekutići, očnjaci i premolari postoje prostrane dijasteme.Broj i vrsta zuba kod različitih vrsta izražavaju se kao dentalna formula. I n/n C n/n P n/n M n/n , gde je I, C, P, M oznaka za incizive, kaninuse, premolare i molare, dok je n/n-odnos gornji i donjih zuba sa svake stane u vilici. Tako dolazimo do dentalne formule kod pacova koja glasi : I: 1-1, C: 0-0, P: 0-0, M: 3-3 2.Hronologija zarastanja rane nakon ekstrakcije zuba -molara i inciziva koja se kod pacova

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Alveolar wound healing and ridge remodeling after tooth extraction in the rat: A histologic, radiographic, and histometric study

Cited by 89 publications

References 11 publications

Cola beverage consumption delays alveolar bone healing: a histometric study in rats

Cola beverage consumption delays alveolar bone healing: a histometric study in rats

Autogenous Demineralized Dentin Graft for Third Molar Socket Regeneration - A Case Report

Healing of extraction wounds in an experimental model of rat

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