Alzheimer's disease and mortality in Japan

Shibata, Nobuto; Arai, Heii

doi:10.1111/j.1479-8301.2009.00273.x

Psychogeriatrics

2009

DOI: 10.1111/j.1479-8301.2009.00273.x

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Alzheimer's disease and mortality in Japan

Nobuto Shibata

Heii Arai

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Cited by 4 publications

(2 citation statements)

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“…Although antipsychotic drugs were originally targeted at schizophrenia, they have recently been prescribed for BPSD because the symptoms of BPSD are similar to those of schizophrenia. There have been many reports of positive effects after the treatment of BPSD with antipsychotics 4,5 . In Japan, there has been widespread acceptance of the use of antipsychotics to treat BPSD, because there are few other useful methods at present to control BPSD.…”

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confidence: 99%

“…There have been many reports of positive effects after the treatment of BPSD with antipsychotics. 4,5 In Japan, there has been widespread acceptance of the use of antipsychotics to treat BPSD, because there are few other useful methods at present to control BPSD. Because of the similarity of the symptoms of BPSD and schizophrenia, we wonder whether there are also similarities in the pathogenesis of the two conditions and whether there are other useful methods available for the management of BPSD that do not rely on the prescription of antipsychotics.…”

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confidence: 99%

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Hypothesis of behavioral and psychological symptoms of dementia

Fujii¹,

Ishizuka²,

Azumi³

et al. 2010

Psychogeriatrics

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mentioning

confidence: 99%

mentioning

confidence: 99%

Hypothesis of behavioral and psychological symptoms of dementia

Fujii¹,

Ishizuka²,

Azumi³

et al. 2010

Psychogeriatrics

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Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors

Ritchie

Carrière

Ritchie

et al. 2010

BMJ

203

171

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Objective To estimate the percentage reduction in incidence of dementia that would be obtained if specific risk factors were eliminated. Design Prospective seven year cohort study. Setting General population, Montpellier, France. Participants 1433 people aged over 65 with a mean baseline age of 72.5 (SD 5.1) years. Main outcome measures Diagnosis of mild cognitive impairment or dementia established by a standardised neurological examination. Results Cox models were constructed to derive hazard ratios and determine confounding and interaction effects for potentially modifiable risk factors for dementia. Mean percentage population attributable fractions were calculated with 95% confidence intervals derived from bootstrapping for seven year incidence of mild cognitive impairment or dementia. The final model retained crystallised intelligence (population attributable fraction 18.11%, 95% confidence interval 10.91% to 25.42%), depression (10.31%, 3.66% to 17.17%), fruit and vegetable consumption (6.46%, 0.15% to 13.06%), diabetes (4.88%, 1.87% to 7.98%), and apolipoprotein E ε4 allele (7.11%, 2.44% to 11.98%). Conclusions Increasing crystallised intelligence and fruit and vegetable consumption and eliminating depression and diabetes are likely to have the biggest impact on reducing the incidence of dementia, outweighing even the effect of removing the principal known genetic risk factor. Although causal relations cannot be concluded with certainty, the study suggests priorities that may inform public health programmes. INTRODUCTIONThe past 30 years have seen the proliferation of methodologically well constructed prospective population studies of dementia that have pointed to multiple risk factors. Although the exact cause of the dementias remains unknown, these studies together suggest a complex interaction of exposures that contribute differentially to the probability and timing of onset of disease. The contribution of epidemiology to dementia research has, however, been principally in the areas

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Influence of Premorbid Psychopathology and Lesion Location on Affective and Behavioral Disorders After Ischemic Stroke

Castellanos-Pinedo

Hernández-Pérez²,

Zurdo³

et al. 2011

JNP

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Early recognition of psychopathological symptoms (PSs) after stroke is important because they greatly influence the recovery of patients. The aim of this study was to investigate the predictive factors of PSs occurring in patients with ischemic stroke. Eighty-nine patients were prospectively evaluated upon admission and 4, 12, and 26 weeks later with the Neuropsychiatric Inventory, Hamilton's Rating Scales for Depression and Anxiety, and a battery of neuropsychological and functional scales. Depression and apathy were the most frequent PSs detected after stroke. Premorbid psychopathologies and right-hemisphere location were the main predictive indicators of early and long-term PSs.

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Alzheimer's disease and mortality in Japan

Cited by 4 publications

References 12 publications

Hypothesis of behavioral and psychological symptoms of dementia

Hypothesis of behavioral and psychological symptoms of dementia

Designing prevention programmes to reduce incidence of dementia: prospective cohort study of modifiable risk factors

Influence of Premorbid Psychopathology and Lesion Location on Affective and Behavioral Disorders After Ischemic Stroke

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