Alzheimer’s disease-related amyloid-β1–42 peptide induces the loss of human sperm function

Tavares, Renata S.; Martins, Soraia; Almeida‐Santos, Teresa; Sousa, Ana Paula; Ramalho‐Santos, João; Silva, Edgar F. da Cruz e

doi:10.1007/s00441-017-2665-1

Cited by 4 publications

(4 citation statements)

References 15 publications

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“…Numerous molecular and neuropathological disorders have been described in AD, such as tau hyperphosphorylation ( Sierra-Fonseca and Gosselink, 2018 ), modification of Ca 2+ signaling pathways ( Glaser et al, 2019 ), and Aβ accumulation ( Naseri et al, 2019 ), leading to neuronal and synaptic disorders ( Cardozo et al, 2019 ). In Alzheimer’s disease, several peripheral organs are also involved, such as the testis ( Tavares et al, 2017 ), pancreas ( Kulas et al, 2017 ), and kidneys ( Paterson et al, 2017 ), indicating a complex systemic disease ( Morris et al, 2014 ). Pathological Aβ accumulation in the kidneys ( Gronewold et al, 2017 ) may result in filtration disorder.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulation of amyloid plaques has also been identified in peripheral organs, resulting in a systemic disorder (Morris et al, 2014;Reglodi et al, 2018c;Pomilio et al, 2020). Among others, Aβ aggregation pathologically alters pancreatic function (Kawarabayashi et al, 1996;Arbor et al, 2016;Tavares et al, 2017) and can negatively affect renal function (Kheirbakhsh et al, 2018).…”

Section: Introductionmentioning

confidence: 99%

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Physical Activity Protects the Pathological Alterations of Alzheimer’s Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways

Perényi

Szegeczki

Horváth

et al. 2020

Front. Cell. Neurosci.

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Alzheimer's disease (AD) is a neurodegenerative disorder with typical amyloid beta (Aβ) aggregations. Elimination of the Aβ precursors via the kidneys makes the organ a potential factor in the systemic degeneration leading to AD. Pituitary adenylate cyclase-activating polypeptide (PACAP) exerts neuroprotective effects in AD and plays a protective role in kidney pathologies. Increased physical activity is preventive of the formation of AD, but its detailed mechanism and possible connections with PACAP have not been clarified. In the kidneys of AD mice, the effects of physical activity were investigated by comparing wild-type and AD organs. Aβ plaque formation was reduced in AD kidneys after increased training (TAD). Mechanotransduction elevated PACAP receptor expression in TAD mice and normalized the protein kinase A (PKA)-mediated pathways. BMP4/BMPR1 elevation activated Smad1 expression and normalized collagen type IV in TAD animals. In conclusion, our data suggest that elevated physical activity can prevent the AD-induced pathological changes in the kidneys via, at least in part, the activation of PACAP-BMP signaling crosstalk.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Physical Activity Protects the Pathological Alterations of Alzheimer’s Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways

Perényi

Szegeczki

Horváth

et al. 2020

Front. Cell. Neurosci.

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“…Formation of amyloid plaques and abnormal function of amyloid-β protein precursor (AβPP) are considered as first signs of the illness not only in the central nervous system (CNS) but also in the periphery [ 4 ]. Compelling evidence supports the pivotal role of amyloid-β (Aβ) in the pathogenesis of AD [ 5 ] pointing out that the decreased clearance of Aβ is one of the key processes in the pathomechanism. In AD, several peripheral organs are involved such as testis [ 5 ], pancreas [ 6 ], and kidney [ 7 ], highlighting the development of a complex systemic disease with multiple targets [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

“…Compelling evidence supports the pivotal role of amyloid-β (Aβ) in the pathogenesis of AD [ 5 ] pointing out that the decreased clearance of Aβ is one of the key processes in the pathomechanism. In AD, several peripheral organs are involved such as testis [ 5 ], pancreas [ 6 ], and kidney [ 7 ], highlighting the development of a complex systemic disease with multiple targets [ 8 ]. It has been proven that the kidney is involved in Aβ clearance [ 9 ].…”

Section: Introductionmentioning

confidence: 99%

Physical Training Inhibits the Fibrosis Formation in Alzheimer’s Disease Kidney Influencing the TGFβ Signaling Pathways

Szegeczki

Perényi

Horváth

et al. 2021

JAD

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Background: Alzheimer’s disease (AD) is a neurodegenerative illness, with several peripheral pathological signs such as accumulation of amyloid-β (Aβ) plaques in the kidney. Alterations of transforming growth factor β (TGFβ) signaling in the kidney can induce fibrosis, thus disturbing the elimination of Aβ. Objective: A protective role of increased physical activity has been proven in AD and in kidney fibrosis, but it is not clear whether TGFβ signalization is involved in this effect. Methods: The effects of long-term training on fibrosis were investigated in the kidneys of mice representing a model of AD (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) by comparing wild type and AD organs. Alterations of canonical and non-canonical TGFβ signaling pathways were followed with PCR, western blot, and immunohistochemistry. Results: Accumulation of collagen type I and interstitial fibrosis were reduced in kidneys of AD mice after long-term training. AD induced the activation of canonical and non-canonical TGFβ pathways in non-trained mice, while expression levels of signal molecules of both TGFβ pathways became normalized in trained AD mice. Decreased amounts of phosphoproteins with molecular weight corresponding to that of tau and the cleaved C-terminal of AβPP were detected upon exercising, along with a significant increase of PP2A catalytic subunit expression. Conclusion: Our data suggest that physical training has beneficial effects on fibrosis formation in kidneys of AD mice and TGFβ signaling plays a role in this phenomenon.

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The Systemic Effects of Exercise on the Systemic Effects of Alzheimer’s Disease

et al. 2022

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Alzheimer’s disease (AD) is a progressive degenerative disorder and a leading cause of dementia in the elderly. The etiology of AD is multifactorial, including an increased oxidative state, deposition of amyloid plaques, and neurofibrillary tangles of the tau protein. The formation of amyloid plaques is considered one of the first signs of the illness, but only in the central nervous system (CNS). Interestingly, results indicate that AD is not just localized in the brain but is also found in organs distant from the brain, such as the cardiovascular system, gut microbiome, liver, testes, and kidney. These observations make AD a complex systemic disorder. Still, no effective medications have been found, but regular physical activity has been considered to have a positive impact on this challenging disease. While several articles have been published on the benefits of physical activity on AD development in the CNS, its peripheral effects have not been discussed in detail. The provocative question arising is the following: is it possible that the beneficial effects of regular exercise on AD are due to the systemic impact of training, rather than just the effects of exercise on the brain? If so, does this mean that the level of fitness of these peripheral organs can directly or indirectly influence the incidence or progress of AD? Therefore, the present paper aims to summarize the systemic effects of both regular exercise and AD and point out how common exercise-induced adaptation via peripheral organs can decrease the incidence of AD or attenuate the progress of AD.

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Alzheimer’s disease-related amyloid-β1–42 peptide induces the loss of human sperm function

Cited by 4 publications

References 15 publications

Physical Activity Protects the Pathological Alterations of Alzheimer’s Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways

Physical Activity Protects the Pathological Alterations of Alzheimer’s Disease Kidneys via the Activation of PACAP and BMP Signaling Pathways

Physical Training Inhibits the Fibrosis Formation in Alzheimer’s Disease Kidney Influencing the TGFβ Signaling Pathways

The Systemic Effects of Exercise on the Systemic Effects of Alzheimer’s Disease

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