Alzheimer’s disease: roles for mitochondrial damage, the hydroxyl radical, and cerebrospinal fluid deficiency of melatonin

Maurizi, C.P.

doi:10.1054/mehy.2001.1324

Cited by 31 publications

(29 citation statements)

References 26 publications

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“…Therefore, no reaction proceeds in stomach due to gastric acids while Si nanopowder reacts with water in bowels with alkaline environment due to pancreatic juice with pH 8.5. Hydrogen molecules are effectively absorbed in bowels, circulate in the whole body, and react with hydroxyl radicals which cause various diseases such as cancers and Parkinson's disease [21][22][23]. Table 1 shows the total hydrogen volume generated by the reaction of Si nanopowder with strong alkaline solutions with pH higher than 12.9, and the maximum hydrogen generation rate.…”

Section: Hydrogen Generation By Reactions Of Si Nanopowder With Watermentioning

confidence: 99%

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Fabrication of Si nanopowder and application to hydrogen generation and photoluminescent material

Kobayashi

Imamura

Matsumoto

et al. 2017

Journal of Electrical Engineering

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Si nanopowder is fabricated using the simple beads milling method. Fabricated Si nanopowder reacts with water in the neutral pH region between 7 and 9 to generate hydrogen. The hydrogen generation rate greatly increases with pH, while pH does not change after the hydrogen generation reaction. In the case of the reactions of Si nanopowder with strong alkaline solutions (eg pH13.9), 1600 mL hydrogen is generated from 1 g Si nanopowder in a short time (eg 15 min). When Si nanopowder is etched with HF solutions and immersed in ethanol, green photoluminescence (PL) is observed, and it is attributed to band-to-band transition of Si nanopowder. The Si nanopowder without HF etching in hexane shows blue PL. The PL spectra possess peaked structure, and it is attributed to vibronic bands of 9,10-dimethylantracene (DMA) in hexane solutions. The PL intensity is increased by more than 3,000 times by adsorption of DMA on Si nanopowder.

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Section: Hydrogen Generation By Reactions Of Si Nanopowder With Watermentioning

confidence: 99%

“…Our finding is expected to be applied to medical use of Si nanopowder, ie internal hydrogen generation to eliminate hydroxyl radicals which cause various diseases such as Alzheimer's disease [21], Parkinson's disease [22], Huntington's disease [23], etc.…”

Section: Introductionmentioning

confidence: 96%

Fabrication of Si nanopowder and application to hydrogen generation and photoluminescent material

Kobayashi

Imamura

Matsumoto

et al. 2017

Journal of Electrical Engineering

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“…44 Moreover, it has been proposed that structural elements in the central hydrophobic core [17][18][19][20][21] and at the C-terminus of Aˇpossess a key role in controlling fibrillogenesis. 45 In addition to the importance of the hydrophobic core of Aˇin its polymerization, it has been reported that regions [5][6][7][8] and [17][18][19][20][21] of the Aˇpeptide can prevent the neurotoxicity of aggregated Aˇ.…”

Section: Mapping Analysis Of the Ab-m Non-covalent Complexmentioning

confidence: 99%

“…1(B)) is a pineal hormone, which has been reported to be significantly reduced in AD patients. 20 This indolamine is suggested to be a potent cellular antioxidant, 21,22 which possesses neuroprotective properties against neurodegenerative diseases and especially AD. 23 Melatonin affects the processing of amyloid precursor protein (APP) in cell lines, 24 protects neurons against Ať oxicity 25 and is able to reverse the action of the protein phosphatase inhibitor okadaic acid, 26 which induces tau hyperphosphorylation and PHF (paired helical filaments)-like pathology.…”

Section: Introductionmentioning

confidence: 99%

Study of the non‐covalent interaction between amyloid‐β‐peptide and melatonin using electrospray ionization mass spectrometry

Bazoti¹,

Tsarbopoulos²,

Markides³

et al. 2005

J. Mass Spectrom.

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Oxidative stress and unregulated immune response are believed to play a key role in the processes inherent to Alzheimer's disease (AD). The fact that free radicals can result in neurodegeneration suggests that actions against reactive oxygen species may be beneficial in treating and preventing AD. In the light of the suggested link between oxidative stress and AD, it is proposed that antioxidants and, even more, endogenous antioxidants may offer a therapeutic regime for protection against the risk of this disease. For this reason, the formation of non-covalent complexes between amyloid-beta-peptide (A beta) or its oxidized forms and melatonin was studied by quadrupole and Fourier transform ion cyclotron resonance electrospray ionization mass spectrometry. The stability of the non-covalent complex was examined under several experimental conditions, such as orifice voltage, pH, presence of organic modifier, concentration and time. Two different digestion protocols combined with mass spectrometric analysis of the resulting peptide fragments were employed in order to locate the binding site of melatonin in A beta.

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“…In AD patients, the hormone is reduced to a far greater extent, thus suggesting that its loss may play a role in the pathogenesis [49, 50, 51, 52]. Melatonin exhibits important antioxidant properties, proved under a wide variety of experimental and pathological conditions [53, 54].…”

Section: Alzheimer’s Diseasementioning

confidence: 99%

Neuroendocrinology of Neurodegenerative Diseases

Aguilar

Frydman²,

Dupuis³

et al. 2003

Neuroendocrinology

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The nervous system plays a key role in the regulation of neuroendocrine axes and, in turn, the released neurohormones modulate the activity of different brain regions. Neurodegenerative diseases, which are known to affect specific neuronal populations, may provoke neuroendocrine dysfunctions that alter the intimate relationship between both systems. In addition, these modifications may influence the progression of the neurodegenerative process. In the present review, we summarise some of the endocrine changes characterising three major neurodegenerative diseases: Alzheimer’s disease, Parkinson’s disease and amyotrophic lateral sclerosis. Special attention is focused on the contribution of disease transgenic models to elucidate such alterations.

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Alzheimer’s disease: roles for mitochondrial damage, the hydroxyl radical, and cerebrospinal fluid deficiency of melatonin

Cited by 31 publications

References 26 publications

Fabrication of Si nanopowder and application to hydrogen generation and photoluminescent material

Fabrication of Si nanopowder and application to hydrogen generation and photoluminescent material

Study of the non‐covalent interaction between amyloid‐β‐peptide and melatonin using electrospray ionization mass spectrometry

Neuroendocrinology of Neurodegenerative Diseases

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