Amantadine in Pediatric Patients with Traumatic Brain Injury

Green, Liza B.; Hornyak, Joseph E.; Hurvitz, Edward A.

doi:10.1097/01.phm.0000143400.15346.c8

Cited by 39 publications

(37 citation statements)

References 22 publications

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“…12 A retrospective, case-controlled study examined changes in recovery in children with TBI who either received amantadine or did not receive neurostimulants. 13 Amantadine administration was associated with a lower initial Ranchos Los Amigos level, but the group that received amantadine did not have a longer length of posttraumatic amnesia or length of stay, suggesting that amantadine may have a beneficial effect. Another retrospective review evaluated children with impaired arousal after a TBI who received various dopaminergic medications, by comparing responsiveness during periods before and after initiation of medication.…”

mentioning

confidence: 94%

Effects of Amantadine in Children with Impaired Consciousness Caused by Acquired Brain Injury

McMahon

Vargus‐Adams

Michaud

et al. 2009

American Journal of Physical Medicine &Amp; Rehabilitation

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mentioning

confidence: 94%

Effects of Amantadine in Children with Impaired Consciousness Caused by Acquired Brain Injury

McMahon

Vargus‐Adams

Michaud

et al. 2009

American Journal of Physical Medicine &Amp; Rehabilitation

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“…In 2004, a retrospective case–controlled study evaluated the use of amantadine in 54 children, ages 3–18 years. Outcomes included change in Rancho Los Amigos Score (Rancho score), length of post-traumatic amnesia, and length of hospital stay [21]. Amantadine use at a dose of 400 mg was well tolerated in the majority of participants.…”

Section: Pharmacological Interventionsmentioning

confidence: 99%

A Narrative Review of Pharmacologic and Non-pharmacologic Interventions for Disorders of Consciousness Following Brain Injury in the Pediatric Population

Evanson

Paulson

Kurowski

2016

Curr Phys Med Rehabil Rep

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Traumatic brain injury (TBI) is the most common cause of long-term disability in the United States. A significant proportion of children who experience a TBI will have moderate or severe injuries, which includes a period of decreased responsiveness. Both pharmacological and non-pharmacological modalities are used for treating disorders of consciousness after TBI in children. However, the evidence supporting the use of potential therapies is relatively scant, even in adults, and overall, there is a paucity of study in pediatrics. The goal of this review is to describe the state of the science for use of pharmacologic and non-pharmacologic interventions for disorders of consciousness in the pediatric population.

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“…23,73,74 In a retrospective, case-controlled study of 54 pediatric patients, Green and colleagues 73 concluded that amantadine was safe and well-tolerated after traumatic brain injury and lead to subjective improvement as well as significant increases in Ranchos Los Amigos scores. Similarly, Beers and colleagues 74 studied the effects of amantadine in pediatric patients after traumatic brain injury and concluded that the medication was safe in this setting.…”

Section: Cognitivementioning

confidence: 99%