(−)-Amarbellisine, a lycorine-type alkaloid from Amaryllis belladonna L. growing in Egypt

Anticancer evaluation of structurally diverse Amaryllidaceae alkaloids and their synthetic derivatives

“…4) belonging to the lycorenine-and crinine-ring type, were respectively isolated from Amaryllis belladonna L. and Clivia nobilis Regel, both cultivated as ornamental plants. The antimicrobial activity of the isolated alkaloids was tested against Gram-positive and Gram-negative bacteria, and the fungus Candida albicans (Evidente et al 1999(Evidente et al , 2004(Evidente et al , 2005.…”

“…In the same time comparative study of the relative and total alkaloid content of two different stages of plant growth were carried out by using HPTLC techniques. The same alkaloids were tested for their antimicrobial activity as reported above (Evidente et al 2004). 11-hydroxyvittatine was also previously isolated from Sterbergia lutea Ker Gawl (Evidente and Motta 2001).…”

Total synthesis of the Amaryllidaceae alkaloid clivonine

“…These alkaloids 15 can mostly be classified as belonging to one of eight skeletally distinct subclasses all derived biosynthetically from a common precursor, norbelladine. [1][2][3] Clivonine (1), along with homolycorine (2), hippeastrine (3) and lycorenine (4) are prominent members of the lycorenine subclass; these alkaloids 20 feature a tetracyclic 2-benzopyrano-[3,4-g]indole skeleton and display growth inhibition of various tumour cells, [4][5][6] DNA binding properties, 7 anti-viral activity, 8,9 antifungal activity, 10 and insect antifeedant activity 11 ( Figure 1). 12 (+)-Clivonine (1) was first isolated as white prisms in 25 0.0007% yield from an ethanolic extract of freshly collected rhizomes and leaves of Clivia miniata Regel in 1956 by Wildman, who also tentatively proposed the correct gross topology of the molecule.…”

Pressurized liquid extraction and anticholinesterase activity-based thin-layer chromatography with bioautography of Amaryllidaceae alkaloids

“…However, there are long-lasting procedures with possible drawbacks of artifacts creation. A percolation [11] and Soxhlet's extraction [12] can do also that.…”