Amberlyst‐15‐catalyzed Procedure for the Synthesis of Novel 2,4‐Dihydroxybenzoyl‐1,2,3‐triazoles and Molecular Modelling Studies for Hsp‐90 Inhibition

Abstract

Novel 4‐and 5‐(2,4‐dihydroxybenzoyl) triazoles were prepared from o‐alkynoylresorcinols with by the cycloaddition reaction performed with metal free one step protocol using Bronsted acid Amberlyst‐15 as catalyst for the first time. This procedure enables the synthesis of triazoles bearing o,p‐dihydroxybenzoyl group without the need to protection of hydroxyl groups. Products were obtained in good to excellent yields and with the moderate regioisomeric ratios. In addition, Hsp90 inhibition activities of synthesized compounds were examined by molecular modelling studies and promising results were obtained.

A novel and robust heterogeneous Cu catalyst using modified lignosulfonate as support for the synthesis of nitrogen-containing heterocycles

“…The first loss within 224-327 °C may be caused by decomposition and elimination of the -SO 3 Na groups and the introduced small organic species in the materials [22], while the second loss at higher temperature of 327-448 °C may be attributed to decomposition of the support skeleton [23]. The thermal stability of referential Resin-Cu catalyst was also investigated by TG analysis (Supporting Informa-tion File 1, Figure S3), showing a high thermal stability as well [24][25][26]. The above results indicated that all prepared materials could remain stable in the system when used to catalyze organic reactions.…”