Ambient air pollution on fecundity and live birth in women undergoing assisted reproductive technology in the Yangtze River Delta of China

Zhang, Chuyue; Yao, Ning; Lu, Yao; Ni, Jingyi; Liu, Xiaohui; Zhou, Ji; Wang, Wangsheng; Zhang, Ting; He, Yang; Huang, Jiaan; Sun, Kang; Sun, Yun

doi:10.1016/j.envint.2022.107181

Cited by 20 publications

(6 citation statements)

References 41 publications

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“…In line with this finding, one recent publication indicated that participants who received FET were more affected following ambient air pollution. 21 One retrospective cohort study conducted in Xiamen, China also found that SO2 and O3 exposures were significantly correlated to live birth rates in frozen cycles. 26 However, Shi et al found that the higher level of PM10 (the median of PM10 was 50 μg/m 3 approximately) could decrease the rates of live birth in fresh cycles but not affect the FET outcomes.…”

Section: Discussionmentioning

confidence: 99%

“…In this study, we observed that significant associations of PM2.5, PM10, SO2 and CO exposures with decreased likelihood of pregnancy, which is consistent with existing publication. 21,[41][42][43] For example, an exploratory retrospective cohort study of 1,139 IVF attempts with 518 clinical pregnancy in Chengdu from 2014 to 2019 showed that PM2.5, PM10, NO2, SO2 and CO was negatively associated with biochemical pregnancy and clinical pregnancy rate, while O3 was positively associated with the two outcomes. 42 Nevertheless, two research reported null association of PM2.5 with pregnancy loss, live birth and clinical pregnancy from oocyte retrieval to embryo transfer.…”

Section: Discussionmentioning

confidence: 99%

“…Specifically, exposure to O3 increased the likelihood of biochemical pregnancy and clinical pregnancy in both single-and two-pollutant models, which is in line with two previous investigations performed in China. 21,42 In fact, the formation of near-surface O3 is another secondary pollutant in air formed from the interaction of precursor pollutants (i.e., nitrogen oxide, volatile organic compounds, and CO) with sunlight. 47 Thus, negatively correlation of nearsurface O3 concentration with concentrations of those precursors.…”

Section: Discussionmentioning

confidence: 99%

“…Despite that some publications have linked air pollution with high risks of adverse pregnancy outcomes, 20,21 evidence on such impacts in ART patients is limited and mixed. 22,23 Some reported adverse effects on IVF outcomes, [24][25][26][27] whereas others observed non-significant or opposing results.…”

Section: Introductionmentioning

confidence: 99%

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Individual-level air pollutants exposure and pregnancy outcomes in patients who underwent assisted reproductive technology: A retrospective longitudinal cohort study

Fang,

Guo,

Jiang

et al. 2023

Preprint

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Background The effects of air pollution on the results of assisted reproductive technology (ART) treatment in terms of pregnancy outcomes were inconclusive. Methods We performed an individual-level retrospective longitudinal cohort study among 11,968 participants undergoing ART treatment from a general hospital in Hefei, China in 2013-20. Monthly mean concentrations of air pollutants [fine particulate matter (PM2.5), suspended particulate matter (PM10), ozone (O3), sulfur dioxide (SO2), Nitrogen dioxide (NO2) and carbon oxide (CO)] during 3 Periods were obtained from ChinaHighAirPollutants (CHAP) dataset: respective Periods 1, 2 and 3 refer to 90 days, one or two years prior to oocyte retrieval. Multiple logistic regression model was applied to explore the impact of air pollution on four ART results (biochemical pregnancy, clinical pregnancy, pregnancy loss, and live birth). Results We observed negative relationships of PM10, PM2.5, CO and SO2 exposures with pregnancy outcomes were more evident during one year exposure (Period 2). An interquartile range increment of ambient PM10, PM2.5, CO, and SO2 exposures during Period 2 was associated with respective decrements of 5.85% (aOR: 0.94, 95% CI: 0.90–0.99), 7.82% (aOR: 0.92, 95% CI: 0.88–0.97), 10.60% (aOR: 0.89, 95% CI: 0.82–0.93) and 12.38% (aOR: 0.88, 95% CI: 0.82–0.93) on clinical pregnancy, while O3 and NO2 showed positive associations. Associations were stronger in patients undergoing frozen embryo transfer, aged < 32 years, with normal BMI, employed status, one embryo transferred, and in warm season. Conclusions Our data show that long-term individual-level exposure to the air pollutants of PM10, PM2.5, CO, SO2 but not O3 or NO2, especially in one year exposure before oocyte retrieval, could have a negative impact on ART outcomes.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Individual-level air pollutants exposure and pregnancy outcomes in patients who underwent assisted reproductive technology: A retrospective longitudinal cohort study

Fang,

Guo,

Jiang

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…Ambient particulate matter in the air has been identified to adversely affect the sperm motility and induce the incidence of asthenozoospermia ( 12 ). The exposure to air pollution in pre-pregnancy and pregnancy stages has been found to associate with adverse pregnancy outcomes including lower clinical pregnancy rate and live birth rate and higher pregnancy loss rate ( 13 , 14 ). However, there is a lack of research on the relationship between air pollution and PCOS.…”

Section: Introductionmentioning

confidence: 99%

Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome

Zhu

Cai

Guo

et al. 2022

Front. Public Health

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BackgroundRecently, the relationship between air pollution and reproductive outcomes has become a research focus. However, there is a lack of research on the relationship between air pollution and polycystic ovary syndrome (PCOS).MethodsThis is a retrospective cohort study included a total of 1,652 women with PCOS and 12,543 women without PCOS conducted from 1 January 2015 to 31 December 2019. The average daily concentration data of six air pollutants (PM2.5, PM10, O3, NO2, SO2, and CO) during different exposure windows were obtained. Generalized estimating equation models were used to evaluate the association of air pollution with pregnancy outcomes.ResultsAir pollutants were not found to have a significant association with pregnancy rates among patients with PCOS. However, each IQR increase in PM10 exposure during period 3 (embryo transfer to serum HCG test) was associated with the reduced clinical pregnancy rate (adjusted OR = 0.92, 95% CI: 0.84–0.99) for patients without PCOS. Patients without PCOS showed lower clinical pregnancy rates with increased exposure to NO2 during periods 2 (oocyte retrieval to embryo transfer) and 5 (start of gonadotropin medication to embryo transfer), with aORs and 95% CIs of 0.94 (0.88, 0.99) and 0.94 (0.88, 0.98), respectively. Each IQR increase in SO2 among patients without PCOS during periods 1 (start of gonadotropin medication to oocyte retrieval), 2, 5, and 6 (start of gonadotropin medication to serum HCG test) was related to a decrease in clinical pregnancy rate. For the live birth rate, no significant relationship was found between air pollutants, including PM2.5, PM10, SO2, NO2, CO, and O3, and the live birth rate for women with PCOS. However, women without PCOS presented a lower probability of live birth with exposure to SO2 during periods 1, 2, 5, and 6.ConclusionThis retrospective study of reproductive-aged women observed no significant relationships between ambient pollutants and pregnancy outcomes among women with PCOS but found negative associations among women without PCOS.

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Does exposure to air pollution during different time windows affect pregnancy outcomes of in vitro fertilization treatment? A systematic review and meta-analysis

et al. 2023

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Ambient air pollution on fecundity and live birth in women undergoing assisted reproductive technology in the Yangtze River Delta of China

Cited by 20 publications

References 41 publications

Individual-level air pollutants exposure and pregnancy outcomes in patients who underwent assisted reproductive technology: A retrospective longitudinal cohort study

Individual-level air pollutants exposure and pregnancy outcomes in patients who underwent assisted reproductive technology: A retrospective longitudinal cohort study

Air pollution exposure and pregnancy outcomes among women with polycystic ovary syndrome

Does exposure to air pollution during different time windows affect pregnancy outcomes of in vitro fertilization treatment? A systematic review and meta-analysis

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