Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects.

Pope, C. Arden; Hansen, Matthew; Long, Russell; Nielsen, Karen R.; Eatough, Norman L.; Wilson, William E.; Eatough, Delbert J.

doi:10.1289/ehp.6588

Cited by 438 publications

(319 citation statements)

References 34 publications

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“…These studies have found that the elderly with or without cardiovascular conditions, hypertension or diabetes may be more responsive to airborne particle exposure and have a larger reduction of the HRV in relation to an increase in PM 2.5 ambient concentrations (Liao et al, 1999;Pope et al, 1999Pope et al, , 2004bGold et al, 2000;Holguı´n et al, 2003). Our findings are consistent with those even though we studied young healthy adults; as expected, the magnitude of association was larger in those studies where susceptible individuals were included than in ours.…”

Section: Discussionsupporting

confidence: 92%

Ambient fine particles modify heart rate variability in young healthy adults

Vallejo

Ruiz

Hermosillo

et al. 2005

J Expo Sci Environ Epidemiol

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Particulate air pollution has been related with cardiopulmonary morbidity and mortality. Recent studies have shown that an increase in particulate matter (PM) 2.5 ambient concentrations was associated with a decrease in heart rate variability (HRV) in the elderly with cardiovascular conditions, which could increase the risk of death. In order to assess if this association could also be observed in young adults, we studied 40 young healthy residents of the Mexico City Metropolitan Area (MCMA) who underwent 13 h Holter electrocardiographic and PM 2.5 personal monitoring. HRV was evaluated in time domain: the standard deviation of normal RR intervals (SDNN) and the percentage of differences between adjacent normal RR intervals larger than 50 ms (pNN50). In multivariate analysis with mixed effects models, a significant negative association of pNN50 with PM 2.5 accumulative exposure was found. An increase in 30 mg/m 3 of the average PM 2.5 personal exposure in the previous 2 h decreased the pNN50 in 0.08% (P ¼ 0.01). This observation revealed an acute effect related to environmental exposure to PM 2.5 with regard to HRV in normal youngsters. The long-term health consequences of this association in young healthy adults remain to be clarified.

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Section: Discussionsupporting

confidence: 92%

Ambient fine particles modify heart rate variability in young healthy adults

Vallejo

Ruiz

Hermosillo

et al. 2005

J Expo Sci Environ Epidemiol

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“…Studies from several laboratories including our own (15, 19, 32, 48 -50) have demonstrated that a systemic inflammatory response is induced by exposure to ambient particulate matter exposure, supporting the hypothesis put forward by Seaton and colleagues (41). This systemic response is characterized by an increased release of PMN (49) and monocytes (19) from the bone marrow as well as elevated levels of circulating cytokines such as IL-6 and IL-1␤ (48), CRP (36), and procoagulation factors (15,32). Elevated levels of these proinflammatory effector cells and mediators in the circulation have been implicated in the pathogenesis of progression and destabilization Fig.…”

Section: Discussionsupporting

confidence: 71%

“…The concept that exposure to PM 10 is associated with a systemic inflammatory response has been supported by other studies showing an increase in C-reactive protein (CRP) levels (36,39), a biomarker of cardiovascular diseases. We recently demonstrated (45) that chronic exposure to PM 10 causes downstream vascular effects that result in progression of atherosclerosis, and this has recently been confirmed in human studies (25).…”

mentioning

confidence: 91%

Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques

Yatera

Hsieh²,

Hogg³

et al. 2008

American Journal of Physiology-Heart and Circulatory Physiology

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demiologic studies have shown an association between exposure to ambient particulate air pollution Ͻ10 m in diameter (PM10) and increased cardiovascular morbidity and mortality. We previously showed that PM10 exposure causes progression of atherosclerosis in coronary arteries. We postulate that the recruitment of monocytes from the circulation into atherosclerotic lesions is a key step in this PM10-induced acceleration of atherosclerosis. The study objective was to quantify the recruitment of circulating monocytes into vessel walls and the progression of atherosclerotic plaques induced by exposure to PM10. Female Watanabe heritable hyperlipidemic rabbits, which naturally develop systemic atherosclerosis, were exposed to PM10 (EHC-93) or vehicle by intratracheal instillation twice a week for 4 wk. Monocytes, labeled with 5-bromo-2Ј-deoxyuridine (BrdU) in donors, were transfused to recipient rabbits as whole blood, and the recruitment of BrdU-labeled cells into vessel walls and plaques in recipients was measured by quantitative histological methodology. Exposure to PM10 caused progression of atherosclerotic lesions in thoracic and abdominal aorta. It also decreased circulating monocyte counts, decreased circulating monocytes expressing high levels of CD31 (platelet endothelial cell adhesion molecule-1) and CD49d (very late antigen-4 ␣-chain), and increased expression of CD54 (ICAM-1) and CD106 (VCAM-1) in plaques. Exposure to PM10 increased the number of BrdU-labeled monocytes adherent to endothelium over plaques and increased the migration of BrdU-labeled monocytes into plaques and smooth muscle underneath plaques. We conclude that exposure to ambient air pollution particles promotes the recruitment of circulating monocytes into atherosclerotic plaques and speculate that this is a critically important step in the PM10-induced progression of atherosclerosis. atherosclerosis; adhesion molecules EPIDEMIOLOGIC STUDIES have associated exposure to ambient particulate air pollution Ͻ10 m in diameter (PM 10

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“…Several studies have previously reported that changes in heart rate (HR) and HR variability (HRV) that were associated with increases in PM mass, both with PM 2.5 (Gold et al, 2000;Liao et al, 1999;Pope et al, 2004) and PM 10À2.5 (Lipsett et al, 2006). Peters et al (1999) documented an association between increase in HR and an air pollution episode in Germany.…”

Section: Issues In Health Effects Assessmentmentioning

confidence: 99%

“…In population-based studies, Peters et al (1999) reported increased HR during an air pollution episode, and Pope et al (2004) reported changes in HRV with ambient PM concentration.…”

Section: Introductionmentioning

confidence: 99%

Effects of thoracic and fine PM and their components on heart rate and pulmonary function in COPD patients

Hsu

Ito

Lippmann

2011

J Expo Sci Environ Epidemiol

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Population-based personal exposures to particulate matter (PM) and personal-ambient relationships of PM and component concentrations for outpatients with COPD and/or asthma were investigated in New York City (NYC) and Seattle for thoracic PM (PM 10 ) and fine PM (PM 2.5 ). Measurements of outdoor, indoor, and personal PM 10 and PM 2.5 concentrations were made concurrently for 12-consecutive days at 24 patients' residences. Filters were analyzed for elemental components, using XRF and black carbon (BC), by reflectance. Daily morning and evening measurements of heart rate (HR) and blood oxygen saturation (SpO 2 ) by pulse oximeter, and forced expiratory volume in 1 s (FEV 1 ) and peak expiratory flowrate (PEF) by spirometry were also measured, and symptom data were collected. Central monitoring site, outdoor, indoor, and personal concentrationresponse relationships of PM 2.5 , PM 10À2.5 , and their components were examined using mixed-effect models. The relatively small sample size of the study limited the interpretation of results, but of the PM chemical components examined, only nickel concentrations showed consistent associations, and only with HR in the NYC COPD patients.

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Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects.

Cited by 438 publications

References 34 publications

Ambient fine particles modify heart rate variability in young healthy adults

Ambient fine particles modify heart rate variability in young healthy adults

Particulate matter air pollution exposure promotes recruitment of monocytes into atherosclerotic plaques

Effects of thoracic and fine PM and their components on heart rate and pulmonary function in COPD patients

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