“…[24][25][26] DOX, one of the most effective chemotherapy drugs, was commonly used in the treatment of various cancers, such as breast cancer, lung cancer, ovarian cancer, etc. [27][28][29] However, the clinical dose of DOX is seriously limited due to its severe toxic side effects, especially for its cardiotoxicity. [30][31][32] To circumvent these limitations, numerous polymeric prodrugs with DOX conjugated through pH-cleavable hydrazone bonds have been fabricated.…”