Ambulatory blood pressure profile in hypertensive patients with β-thalassemia minor

Vyssoulis, Gregory P.; Karpanou, Eva A.; Sm, Kyvelou; Tzamou,; Triantafyllou, Αreti; Theodosiadis, G.; Stefanadis, Christodoulos

doi:10.1038/hr.2010.226

Cited by 11 publications

(9 citation statements)

References 31 publications

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“…[ 12 , 13 , 14 ]. Further reinforcing this link, in a study by Vyssoulis et al [ 15 ], hypertensive patients with βTM presented a better 24-hour blood pressure profile compared to patients without βTM.…”

Section: Discussionmentioning

confidence: 76%

Is β-Thalassaemia Minor Associated with Metabolic Disorder?

Kırım¹,

Keşkek²,

Turhan³

et al. 2014

Med Princ Pract

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Objective: To investigate the frequency of metabolic syndrome and its components in subjects with β-thalassaemia minor. Subjects and Methods: A total of 194 subjects, i.e. 92 subjects with β-thalassaemia minor (study group) and 102 subjects without β-thalassaemia minor (control group), were enrolled into this case-control study. Haemoglobin electrophoresis was performed on all patients. The waist circumference and systolic and diastolic blood pressure of the subjects were recorded. Fasting blood glucose and serum lipid levels were measured. Results: Both groups were similar in terms of age and sex (p > 0.05 for each). The percentages of haemoglobin A₂ (4.3 ± 0.4 vs. 2.0 ± 0.3) and haemoglobin F (3.38 ± 1.4 vs. 0.26 ± 0.4) and the mean corpuscular volumes (64 ± 4.7 vs. 81.5 ± 9.3) of the groups were statistically different (p < 0.001 for each). The frequency of metabolic syndrome and its components was similar in both groups (p > 0.05 for each). According to correlation analyses, the percentage of haemoglobin A₂ correlated with fasting insulin, fasting glucose, systolic blood pressure, high-density lipoprotein, and low-density lipoprotein levels (p < 0.05). Conclusions: No association was found between β-thalassaemia minor and metabolic syndrome despite insulin resistance, which was shown in subjects with β-thalassaemia minor.

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Section: Discussionmentioning

confidence: 76%

Is β-Thalassaemia Minor Associated with Metabolic Disorder?

Kırım¹,

Keşkek²,

Turhan³

et al. 2014

Med Princ Pract

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“…Thalassemia major patients with diabetes mellitus had a higher risk of cardiac complications, including heart failure, hyperkinetic arrhythmias, and myocardial fibrosis [ 93 ]. A protective effect of beta-thalassemia against myocardial infarction was demonstrated in thalassemia minor due to a favorable lipidemic profile, a better cardiovascular risk factor, and 24 h blood pressure profile, compared with anemic and nonanemic hypertensives [ 94 , 95 ].…”

Section: Cardiovascular Consequences Of Hereditary Forms Of Anemiamentioning

confidence: 99%

Mechanisms Linking Red Blood Cell Disorders and Cardiovascular Diseases

Mozoş

2015

BioMed Research International

130

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The present paper aims to review the main pathophysiological links between red blood cell disorders and cardiovascular diseases, provides a brief description of the latest studies in this area, and considers implications for clinical practice and therapy. Anemia is associated with a special risk in proatherosclerotic conditions and heart disease and became a new therapeutic target. Guidelines must be updated for the management of patients with red blood cell disorders and cardiovascular diseases, and targets for hemoglobin level should be established. Risk scores in several cardiovascular diseases should include red blood cell count and RDW. Complete blood count and hemorheological parameters represent useful, inexpensive, widely available tools for the management and prognosis of patients with coronary heart disease, heart failure, hypertension, arrhythmias, and stroke. Hypoxia and iron accumulation cause the most important cardiovascular effects of sickle cell disease and thalassemia. Patients with congenital chronic hemolytic anemia undergoing splenectomy should be monitored, considering thromboembolic and cardiovascular risk.

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“…Besides, decreased blood viscosity due to the decreased hematocrit level can improve circulation [12,13]. In accordance with this link, hypertensive patients with BTM presented with a better 24-h blood pressure profile compared to patients without BTM [14]. Baserga et al [15] reported a lower incidence of hypertension in subjects with BTM.…”

Section: Discussionmentioning

confidence: 52%

Better Renal Resistive Index Profile in Subjects with Beta Thalassemia Minor

2018

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Objective: Beta thalassaemia minor is a common genetic disorder without any characteristic symptoms except mild anemia. It is found to be associated with some cardiovascular risk factors such as insulin resistance and diabetes mellitus. The renal resistive index (RRI) is a measure of renal arterial resistance to blood flow. The aim of this study was to evaluate the RRI in subjects with beta thalassemia minor (BTM). Subjects and Methods: A total of 253 subjects were included in this cross-sectional study. The study group consisted of 148 subjects with BTM and the control group consisted of 105 healthy subjects. BTM was diagnosed by a complete blood count and hemoglobin electrophoresis. Blood pressure measurement and biochemical tests were performed. The RRI of all subjects was measured using renal Doppler ultrasonography. Results: Subjects with BTM had lower renal resistive indices compared to healthy subjects (0.58 ± 0.04 vs. 0.60 ± 0.06, p = 0.0016). Additionally, the RRI levels of subjects with BTM were correlated with systolic blood pressure (p = 0.017, r = 0.194). Conclusion: In this study, lower RRI were found in subjects with BTM. This may be associated with a decreased vascular resistance and blood viscosity in these subjects.

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Ambulatory blood pressure profile in hypertensive patients with β-thalassemia minor

Cited by 11 publications

References 31 publications

Is β-Thalassaemia Minor Associated with Metabolic Disorder?

Is β-Thalassaemia Minor Associated with Metabolic Disorder?

Mechanisms Linking Red Blood Cell Disorders and Cardiovascular Diseases

Better Renal Resistive Index Profile in Subjects with Beta Thalassemia Minor

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