With its wide range of dissemination, Entamoeba histolytica poses a serious threat in practically any nation where there is a regular barrier between human waste, food, and water sources. Except E. histolytica, at least eight distinct amoebas are thought to be commensals in the human intestinal lumen. As the second biggest cause of death from parasitic disease globally, the parasite poses a serious threat to public health in most regions of the world and has reemerged in several previously inactive locations. The majority of E. histolytica infections have very minor or no symptoms, however, colitis and liver abscesses brought on by amoebic infections are the most common clinical manifestations. Typically, a laboratory's diagnosis of amoebiasis is based on a microscope.