Amelanotic Malignant Melanoma of Unknown Primary Origin Metastasizing to the Bone Marrow: A Case Report and Review of the Literature

Suzuki, Tomotaka; Kusumoto, Shigeru; Iida, Shinsuke; Tada, Toyohiro; Mori, Fumiaki

doi:10.2169/internalmedicine.53.1412

Cited by 12 publications

(10 citation statements)

References 15 publications

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“…Other similar morphologic findings, included basophilic cytoplasm, cytoplasmic vacuoles, and prominent mitoses. All case series patients showed expected positivity for melanoma markers, including S100, HMB45, and Melan A, which was comparable to the literature that reported immunohistochemical staining results …”

Section: Discussionsupporting

confidence: 89%

Bone marrow findings in metastatic melanoma, including role of BRAF immunohistochemistry

Corean

George

Patel

et al. 2019

Int J Lab Hematology

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Introduction We describe peripheral blood smear, bone marrow morphology, histopathology, immunohistochemistry, including BRAF V600E, and molecular testing results of patients with metastatic melanoma to the bone marrow. Methods We performed a retrospective review for patients with metastatic melanoma to the bone marrow at our institution. Bone marrow morphology, histology, immunophenotyping, and cytogenetic/molecular genetic testing were reviewed, and BRAF V600E immunohistochemistry was performed. Results were compared to the literature. Results We identified four patients with metastatic melanoma to the bone marrow presenting with at least one cytopenia. Two of the four patients had leukoerythroblastosis, with three patients having atypical cells on bone marrow aspirate/touch preparation, and all patients had aggregates of atypical cells on biopsy. Immunohistochemistry for S100, Melan A, and HMB45 confirmed the diagnosis in all patients, and BRAF V600E immunohistochemistry was detected in two of four patients, which correlated with molecular testing findings. Review of the literature found 27 total patients, with normocytic anemia and leukoerythroblastosis as common peripheral blood smear findings. Conclusions Features including cytopenias (typically anemia), leukoerythroblastosis, and morphology of cohesive, large atypical cells in aspirate and biopsy, and immunohistochemical expression for S100, Melan A, and HMB45 were present in patients with metastatic melanoma. BRAF V600E immunohistochemistry is useful as a surrogate marker of molecular results. Regardless of clinical history, at the time of the bone marrow biopsies, hematologic malignancies are in the main differential diagnosis and very rarely included metastatic melanoma, likely due to the under‐recognized metastatic potential of melanoma to the bone marrow.

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Section: Discussionsupporting

confidence: 89%

Bone marrow findings in metastatic melanoma, including role of BRAF immunohistochemistry

Corean

George

Patel

et al. 2019

Int J Lab Hematology

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“…Ama bizim hastamızda bariz bir lökositoz vardı. Wolff ve arkadaşlarının olgu sunumunda da lökositoz vardı (10) ancak Deepali ve arkadaşlarının sundukları olgu sunumunda lökositoz saptanmamıştı (11 (13). Son yayın ise 2018 yılına aittir (7) ve bu olgu sunumundaki hasta kombine immünterapi ile tedaviye iyi yanıt vermiştir.…”

Section: Discussionunclassified

Malign Melanoma with Bone Marrow Involvement: A Case Report

Yıldırım¹,

Saygılı²,

Taşlı³

et al. 2019

Acta Oncol Tur.

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ÖZETNodüler tip malign melanom nadir görülen bir malign melanom alt tipidir. Sıklıkla ileri evrede tanı alır ve kötü prognozludur. Bu olgu sunumunda nadir olarak rastlanan, karakteristik cilt bulguları olan, kemik iliği tutulumu ve yaygın damar içi pıhtılaşma tablosunun bir arada bulunduğu bir nodüler tip malign melanom vakası sunuyoruz. Anahtar Kelimeler: Metastatik malign melanom, Nodüler melanom, kemik iliği tutulumu, intravasküler hemoliz, yaygın damar içi pıhtılaşma ABSTRACT Nodular type malignant melanoma a rare subtype of malignant melanoma with poor prognosis. It is often diagnosed at advanced stage. In this case report, we present a metastatic malign melanom case with bone marrow involvement and dissemine intravascular haemolysis.

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“…In the present work, we report an unusual case of metastatic malignant melanoma without identification of a primary tumor in a sheep. The entity of melanomas of unknown primary (MUP) origin and their criteria has been characterized and described in human beings (7,8,18). In man, different theories, such as the spontaneous regression of the pre-existing nevus as the primary site because of involvement of immunological mechanisms have been proposed to explain the phenomenon of MUP origin (7,13,20).…”

Section: Discussionmentioning

confidence: 99%

“…Although more than 90% of the melanocytic neoplasms usually originate from the skin, these tumors may occur metastatically in other sites without an identified primary lesion (7,8). Such tumors are designated "melanomas of unknown primary origin" (MUP) (18). The present paper describes histopathological and immunohistochemical features of a malignant melanoma metastasized to the visceral organs of a 3-year-old sheep without an identifiable primary site.…”

Section: Introductionmentioning

confidence: 97%

Melanoma of unknown primary origin metastasizing to visceral organs in a sheep

Oryan¹,

Ghane²,

Ahmadi³

et al. 2018

BJVP

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Malignant melanomas are quite uncommon in sheep and goats. A three-year-old native female sheep with a history of sudden death was referred for postmortem examination. Gross evaluations revealed multiple brown to black neoplastic masses with compact nodular appearance, involving lungs, mediastinal lymph nodes, liver and kidneys. Comprehensive physical examination of skin, all mucous membranes and mucocutaneous junctions revealed no evidence of concomitant pigmented lesions or dark discoloration. Microscopically, the masses were predominantly composed of round and polyhedral-shaped neoplastic cells of various sizes with abundant pale eosinophilic cytoplasm containing variable amounts of dark brown melanin pigment and peripherally located, oval to round, vesicular nuclei with prominent nucleoli. Immunohistochemically, the neoplastic cells displayed diffuse and positive expression for S100 protein, vimentin and melan-A. These histopathological and immunohistochemical findings were consistent with a final diagnosis of metastatic malignant melanoma, "epithelioid" type. To the author' knowledge, metastatic melanoma without an identified primary origin has not yet been reported in the domestic animals.

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Amelanotic Malignant Melanoma of Unknown Primary Origin Metastasizing to the Bone Marrow: A Case Report and Review of the Literature

Cited by 12 publications

References 15 publications

Bone marrow findings in metastatic melanoma, including role of BRAF immunohistochemistry

Bone marrow findings in metastatic melanoma, including role of BRAF immunohistochemistry

Malign Melanoma with Bone Marrow Involvement: A Case Report

Melanoma of unknown primary origin metastasizing to visceral organs in a sheep

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