Amelanotic melanoma arising in an area of <scp>SLURP</scp>‐1 mutated Mal de Meleda

Arousse, A.; Mokni, S.; Brahim, D. H’mida Ben; Bdioui, Ahlem; Aounallah, A.; Gammoudi, R.; Saïdi, W.; Boussofara, L.; Ghariani, Najet; Denguezli, M.; Belajouza, C.; Nouira, R.

doi:10.1111/ijd.14231

Cited by 5 publications

(4 citation statements)

References 15 publications

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“…Transcriptome analysis of pancreatic tumors has revealed upregulated expression of many LY6 genes when compared to normal pancreatic tissue [ 3 ]. These findings are consistent with previous reports that show an increased expression of PSCA and other LY6 genes (e.g., SLURP1 ) on a variety of neoplasms arising from prostate, bladder, ovarian, urothelial, and skin tissues [ 6 – 11 ]. Regardless of their chromosomal location, the LY6 proteins are either glycosylphosphatidylinositol (GPI)-anchored to the membrane or are secreted [ 4 ].…”

Section: Introductionsupporting

confidence: 93%

Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma

Rathbun

Magliocco²,

Bamezai

2023

Oncotarget

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Section: Introductionsupporting

confidence: 93%

Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma

Rathbun

Magliocco²,

Bamezai

2023

Oncotarget

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“…SLURP-1 interacts with α7-nAChRs ( Chernyavsky et al, 2015 ; Lyukmanova et al, 2016a ), induces keratinocyte apoptosis ( Arredondo et al, 2005 ), and protects the oral keratinocytes from oncogenic transformation by tobacco-derived nitrosamines ( Arredondo et al, 2007a ; Kalantari-Dehaghi et al, 2012 ). SLURP-1 expression is down-regulated in primary and metastatic melanomas compared with normal cells ( Bergqvist et al, 2018 ; Arousse et al, 2019 ), moreover the elevated level of SLURP-1 in plasma correlates with a better survival prognosis for pancreatic cancer patients ( Throm et al, 2018 ). Thus, SLURP-1 can be considered a prototype antitumor drug, but its effect on cancer and normal cells, its targets and active centers should be studied in details.…”

Section: Introductionmentioning

confidence: 99%

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer

Bychkov

Shulepko

Shlepova

et al. 2021

Front. Cell Dev. Biol.

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Secreted Ly6/uPAR-related protein 1 (SLURP-1) is a secreted Ly6/uPAR protein that negatively modulates the nicotinic acetylcholine receptor of α7 type (α7-nAChR), participating in control of cancer cell growth. Previously we showed, that a recombinant analogue of human SLURP-1 (rSLURP-1) diminishes the lung adenocarcinoma A549 cell proliferation and abolishes the nicotine-induced growth stimulation. Here, using multiplex immunoassay, we demonstrated a decrease in PTEN and mammalian target of rapamycin (mTOR) kinase phosphorylation in A549 cells upon the rSLURP-1 treatment pointing on down-regulation of the PI3K/AKT/mTOR signaling pathway. Decreased phosphorylation of the platelet-derived growth factor receptor type β (PDGFRβ) and arrest of the A549 cell cycle in the S and G2/M phases without apoptosis induction was also observed. Using a scratch migration assay, inhibition of A549 cell migration under the rSLURP-1 treatment was found. Affinity extraction demonstrated that rSLURP-1 in A549 cells forms a complex not only with α7-nAChR, but also with PDGFRα and epidermal growth factor receptor (EGFR), which are known to be involved in regulation of cancer cell growth and migration and are able to form a heterodimer. Knock-down of the genes encoding α7-nAChR, PDGFRα, and EGFR confirmed the involvement of these receptors in the anti-migration effect of SLURP-1. Thus, SLURP-1 can target the α7-nAChR complexes with PDGFRα and EGFR in the membrane of epithelial cells. Using chimeric proteins with grafted SLURP-1 loops we demonstrated that loop I is the principal active site responsible for the SLURP-1 interaction with α7-nAChR and its antiproliferative effect. Synthetic peptide mimicking the loop I cyclized by a disulfide bond inhibited ACh-evoked current at α7-nAChR, as well as A549 cell proliferation and migration. This synthetic peptide represents a promising prototype of new antitumor drug with the properties close to that of the native SLURP-1 protein.

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“…Dysregulation of the α7-nAChR function due to SLURP-1 deficiency or point mutations may underlie MDM pathogenesis. Skin lesions areas in MDM patients represent potential sites for amelanotic melanoma and skin squamous cell carcinomas development (Arousse et al 2019;Bergqvist et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants Differently Affect Keratinocyte Proliferation and Apoptosis

Shulepko

Bychkov

Шенкарев

et al. 2021

Journal of Investigative Dermatology

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Amelanotic melanoma arising in an area of SLURP‐1 mutated Mal de Meleda

Cited by 5 publications

References 15 publications

Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma

Human LY6 gene family: potential tumor-associated antigens and biomarkers of prognosis in uterine corpus endometrial carcinoma

SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer

Biochemical Basis of Skin Disease Mal de Meleda: SLURP-1 Mutants Differently Affect Keratinocyte Proliferation and Apoptosis

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