Ameliorating adverse perinatal outcomes with Lactoferrin: An intriguing chemotherapeutic intervention

Talbert, Julie A.; Lu, Jacky; Spicer, Sabrina K.; Moore, Rebecca E.; Townsend, Steven D.; Gaddy, Jennifer A.

doi:10.1016/j.bmc.2022.117037

Cited by 3 publications

(2 citation statements)

References 154 publications

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“…Additionally, both BLF and HLF have the ability to inhibit the formation of A. baumannii biofilms [ 65 ]. Finally, in vitro and in vivo assays have demonstrated the ability of BLF, HLF, and camel LF to effectively reduce the occurrence of infectious E. coli and Acinetobacter baumannii [ 66 ].…”

Section: The Direct and Indirect Prebiotic Roles Of Lactoferrin In Vi...mentioning

confidence: 99%

“…Additionally, these treatments notably increased the presence of Lactobacillus species. Notably, the balance of the bacterial biota was maintained for up to 2 weeks after treatment, but this effect was observed only in women treated with 200 mg lactoferrin pessaries [ 66 ]. Hence, the administration of LF has been shown to effectively enhance the in vivo growth of specific probiotic strains and exhibit efficacy against infectious pathogen infections.…”

Section: The Direct and Indirect Prebiotic Roles Of Lactoferrin In Vi...mentioning

confidence: 99%

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Featured Prebiotic Agent: The Roles and Mechanisms of Direct and Indirect Prebiotic Activities of Lactoferrin and Its Application in Disease Control

Liu

Chen

2023

Nutrients

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Lactoferrin (LF) is a glycoprotein found in mammalian milk, and lactoferricin is a peptide derived from LF hydrolysate. Both LF and lactoferricin (LFcin) have diverse functions that could benefit mammals. Bovine LF (BLF) and BLFcin exhibit a wide range of antimicrobial activities, but most probiotic strains are relatively resistant to their antibacterial effects. BLF and BLF hydrolysate can promote the growth of specific probiotics depending on the culture conditions, the dose of BLF or BLF-related peptides, and the probiotic strains used. BLF supplementation has been shown to modulate several central molecular pathways or genes in Lacticaseibacillus rhamnosus GG under cold conditions, which may explain the prebiotic roles of BLF. LF alone or in combination with selected probiotics can help control bacterial infections or metabolic disorders, both in animal studies and in human clinical trials. Various LF-expressing probiotics, including those expressing BLF, human LF, or porcine LF, have been developed to facilitate the combination of LFs with specific probiotics. Supplementation with LF-expressing probiotics has positive effects in animal studies. Interestingly, inactivated LF-expressing probiotics significantly improved diet-induced nonalcoholic fatty liver disease (NAFLD) in a mouse model. This review highlights the accumulated evidence supporting the use of LF in combination with selected LF-resistant probiotics or LF-expressing probiotics in the field.

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Section: The Direct and Indirect Prebiotic Roles Of Lactoferrin In Vi...mentioning

confidence: 99%

Section: The Direct and Indirect Prebiotic Roles Of Lactoferrin In Vi...mentioning

confidence: 99%

Featured Prebiotic Agent: The Roles and Mechanisms of Direct and Indirect Prebiotic Activities of Lactoferrin and Its Application in Disease Control

Liu

Chen

2023

Nutrients

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Neonatal sepsis: A review of current management strategies

Sultan,

Ibrahim,

Elmahdy

2024

Journal of Neonatal Nursing

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Estrogen receptors in mitochondrial metabolism: age-related changes and implications for pregnancy complications

Hinton,

Neikirk,

et al. 2024

Aging Advances

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Estrogen hormones are primarily associated with their role as female sex hormones responsible for primary and secondary sexual development. Estrogen receptors are known to undergo age-dependent decreases due to age-related changes in hormone production. In the mitochondria, estrogen functions by reducing the production of reactive oxygen species in the electron transport chain, inhibiting apoptosis, and regulating mitochondrial DNA content. Moreover, estrogen receptors may be the key components in maintaining mitochondrial membrane potential and structure. Although estrogen plays a crucial role in the development of pregnancy, our understanding of how estrogen receptors change with aging during pregnancy remains limited. During pregnancy, estrogen levels are significantly elevated, with a corresponding upregulation of estrogen receptors, which play various roles in pregnancy. However, the exact role of estrogen receptors in pregnancy complications remains to be further investigated. The paper reviews the role of estrogen receptors in the regulation of mitochondrial metabolism and in pregnancy complications, with a special focus on the effect of age-related changes on estrogen levels and estrogen receptors function. We also address how estrogen maintains mitochondrial function, including reducing the production of reactive oxygen species in the electron transport chain, inhibiting apoptosis, regulating mitochondrial DNA content, and maintaining mitochondrial membrane potential and structure. However, the effects of estrogen on mitochondria-endoplasmic reticulum contacts have not been well studied. Based on these emergent roles in mitochondria, the differential roles of estrogen receptors in pregnancy complications are of great relevance. The paper emphasizes the association between maternal health and estrogen receptors and indicates the need for future research to elucidate the interdependence of estrogen receptor-regulated maternal health with mitochondrial function and their relationship with the gut microbiome. Overall, we summarize the important role of estrogen receptors during pregnancy and highlight the need for further research to better understand the role of estrogen receptors in aging and pregnancy complications. This not only helps to reveal the mechanism underlying the role of estrogen in maternal health but also has potential clinical implications for the development of new therapies targeting age-related diseases and pregnancy complications.

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Ameliorating adverse perinatal outcomes with Lactoferrin: An intriguing chemotherapeutic intervention

Cited by 3 publications

References 154 publications

Featured Prebiotic Agent: The Roles and Mechanisms of Direct and Indirect Prebiotic Activities of Lactoferrin and Its Application in Disease Control

Featured Prebiotic Agent: The Roles and Mechanisms of Direct and Indirect Prebiotic Activities of Lactoferrin and Its Application in Disease Control

Neonatal sepsis: A review of current management strategies

Estrogen receptors in mitochondrial metabolism: age-related changes and implications for pregnancy complications

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