2022
DOI: 10.1016/j.phyplu.2022.100268
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Ameliorating and protective potential of 1-isothiocyanato-4-methyl sulfonyl butane on cisplatin induced oligozoospermia and testicular dysfunction via redox-inflammatory pathway: Histomorphometric and immunohistochemical evaluation using proliferating cell nuclear antigen

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Cited by 14 publications
(4 citation statements)
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“…The current findings in the tramadol group revealed a significant reduction in the values of FSH, LH, and testosterone hormones. These findings are parallel to the findings of Adelakun et al (2022) and Ramadan et al (2022) who clarify this reduction by tramadol's direct activity on the hypothalamic-pituitary axis inducing repression of both FSH and LH release. The noteworthy decrease of sexual hormones might be clarified through tramadol boost free radicals' release and exerted harm on both cells of Leydig and Sertoli.…”
Section: Discussionsupporting
confidence: 88%
“…The current findings in the tramadol group revealed a significant reduction in the values of FSH, LH, and testosterone hormones. These findings are parallel to the findings of Adelakun et al (2022) and Ramadan et al (2022) who clarify this reduction by tramadol's direct activity on the hypothalamic-pituitary axis inducing repression of both FSH and LH release. The noteworthy decrease of sexual hormones might be clarified through tramadol boost free radicals' release and exerted harm on both cells of Leydig and Sertoli.…”
Section: Discussionsupporting
confidence: 88%
“…34 The diabetic animals in the current work showed reduced body weight which confirms previous results. 35,36 On the other side, sulbutiamine administration to diabetic animals reversed the observed weight loss and significantly increased the animal body weight. This may be explained by the reported beneficial effect of thiamine on food consumption, and consequently, weight gain in F I G U R E 5 Effect of sulbutiamine on protein kinase C (PKC) and proliferating cell nuclear antigen (PCNA) levels.…”
Section: Discussionmentioning
confidence: 99%
“…CP treatment significantly decreases steroidogenic genes that include StAR, CYP11A1, CYP17A1, HSD17B, and CYP1719A1 compared with other groups [ 11 , 83 ]. Cisplatin has been reported to induce similar impacts [ 84 , 85 ]. HSP administration enhances testicular functions through the upregulation of steroidogenesis-related genes [ 86 ].…”
Section: Discussionmentioning
confidence: 99%