Ameliorating effect of mother tincture of Syzygium jambolanum on carbohydrate and lipid metabolic disorders in streptozotocin-induced diabetic rat: Homeopathic remedy

Abstract

Background:Syzygium jambolanum (S jambolanum) is widely used in homeopathy for treating patients with diabetes mellitus. In the present study, an attempt has been made to investigate the remedial effect of homeopathic drug S jambolanum on carbohydrate and lipid metabolic disorders on streptozotocin induced diabetic rat.Materials and Methods:Diabetes induction in Wistar strain rat was performed as per standard method using streptozotocin at the dose of 4 mg/100 gm body weight. Activities of carbohydrate metabolic enzymes in hepatic tissue, and glycogen content in hepatic and muscular tissues were assessed biochemically following the standard protocols. Serum lipid profile level and activities of GOT and GPT in serum were measured as per standard method using specific kits.Results:The homeopathic drug, mother tincture of S jambolanum significantly decreased fasting blood glucose levels and improved carbohydrate metabolic key enzyme activities in hepatic tissue i.e., hexokinase, glucose-6-phosphate dehydrogenase and glucose-6-phosphatase in diabetic rats. Alongside, serum lipid profile biomarkers i.e., triglyceride (TG), total cholesterol (TC), low density lipoprotein cholesterol (LDLc), very low density lipoprotein cholesterol (VLDLc) and high density lipoprotein cholesterol (HDLc) levels were significantly ameliorated in homeopathic drug supplemented diabetic animals in compared with the untreated diabetic animal. Side by side, the S jambolanum has the capacity to attenuate diabetes induced hepatic injury in model animal, which has been assessed here by the recovery of GOT and GPT activities in serum of drug treated diabetic animal.Conclusion:The result of the present study indicated that the homeopathic drug S jambolanum (mother tincture) has a protective effect on diabetic induced carbohydrate and lipid metabolic disorders in STZ-induced diabetic animal.

Synergistic effect of nano-selenium and metformin on type 2 diabetic rat model: Diabetic complications alleviation through insulin sensitivity, oxidative mediators and inflammatory markers

“…ALT and AST transaminases are closely linked biomarkers to hepatic tissue damage [60]. It has been established that the increase of serum activities of transaminases, GGT, and ALP in T2D-induced rats may be due to hepatic injury linked with STZ resulting in leakage of these enzymes from the liver into plasma [61]. The current study has shown that treatment with Se-NPs and/or MET as monotherapy and also combined therapy restored the activities of ALT, AST, GGT and ALP toward normal levels as well as the levels of albumin, total protein and bilirubin returned near to normal levels.…”

Green Coffee Bean Extract Potentially Ameliorates Liver Injury due to HFD/STZ-Induced Diabetes in Rats

“…Transaminases (ALT and AST) are extremely sensitive biomarkers that have been directly associated with toxicity and liver impairment [56]. According to Ghosh et al, signifcant elevations in ALT and AST activity in the serum of diabetic rats may be primarily caused by the leakage of these enzymes from the liver cytosol into the circulation as a result of hepatic damage linked to STZ [57]. Te results of the HFD/STZ group in the present study were matched with the previous studies [56,58,59].…”