Ameliorating effects of garlic, calcium, and vitamin C on chronic lead toxicity in albino rats

Haridy, Mohie; Sakai, Hiroki; Mohi-Eldin, Mouchira M.

doi:10.1007/s00580-013-1765-x

Cited by 7 publications

(6 citation statements)

References 22 publications

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“…However, their spleen and kidney tissues were severely damaged, findings in accordance with those of other scholars [22,23]. Kidney damage caused by lead has been confirmed by clinical observation and epidemiologic studies [24][25][26][27]. The kidney is the major target organ of lead toxicity.…”

Section: Discussionsupporting

confidence: 74%

Effect of LA on the Growth and Development of the Main Organs in Female Mice

Feng

et al. 2016

Biol Trace Elem Res

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Effects of lead acetate (LA) on the growth and development of major organs in female mice were studied. Female mice were divided randomly into four treatment groups and one control group. In treatment groups, mice were injected with different concentrations of LA solution every 2 days; whereas control-group mice received equal volumes of sterile normal saline. Body weight (BW) and symptoms were recorded every 2 days. After LA exposure, mice were executed by cervical dislocation and main organs (heart, liver, spleen, lung, kidney) collected for evaluation of morphologic and histologic changes. LA could greatly affect increases in BW, and BW decreased with increasing dose and time of exposure to LA. Compared with the control group, organ coefficients in treatment groups were of the order kidney and spleen > liver and lung > heart and demonstrated obvious dose-time effects. LA exposure could damage the heart, liver, spleen, lung, and kidney. Damage to the kidney and spleen was the most severe, followed by that to the liver, heart, and lung. Damage was aggravated with increasing doses and exposure time to LA in an obvious dose-time relationship; when LA dose was ≥20 mg/kg, the growth and development of mice were obviously inhibited. These results suggest that long-term exposure to low-dose LA can result in universal pathologic damage to mouse organs and that severity is dependent on the dose and duration of LA exposure.

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Section: Discussionsupporting

confidence: 74%

Effect of LA on the Growth and Development of the Main Organs in Female Mice

Feng

et al. 2016

Biol Trace Elem Res

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“…The effects of some nutritional factors, including zinc against lead toxicity have been studied but reports have been inconsistent. [20][21][22][23] Zinc is an essential trace element that plays important role in multiple metabolic reactions and activities, including the structural stability of Zn-dependent proteins and in counteracting the toxic effects of chemical elements, 24,25 , though toxic at higher concentration. 26 While evidence from both human and animal [27][28][29][30] studies suggest beneficial effects of Zn against Pb toxicity, other studies reported contrary effects.…”

Section: Introductionmentioning

confidence: 99%

Zinc ameliorates lead toxicity by reducing body Pb burden and restoring Pb-induced haematological and biochemical derangements

Ugwuja

Ikaraoha

et al. 2020

Toxicology Research and Application

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Background: Studies on nutritional factors, including zinc in ameliorating the deleterious effects of potentially toxic elements have been scarce and the findings have been inconsistent. Aim: The aim of the present study was to evaluate the ameliorative potential of zinc against lead-induced toxicity in rats. Materials and methods: Male albino rats (n = 24) assigned into four groups of six/group: normal control (NC), zinc control (ZnC; 20 mg/kg ZnCl2), lead control (PbC; 50 mg/kg PbCl2) and lead plus zinc (Pb + Zn; 50 mg/kg PbCl2 plus 20 mg/kg ZnCl2), respectively were investigated. All administrations were through oral route and lasted for 42 days after which blood samples were collected for haematological and biochemical analyses using standard techniques. Results: Results showed that packed cell volume (PCV), haemoglobin concentration (HBC), red blood cell count (RBC) were significant (p < 0.05) reduced while total white blood cell count (TWBC), mean corpuscular haemoglobin (MCH), mean corpuscular haemoglobin concentration (MCHC) and platelets were significantly elevated in PbC group in comparison with NC and ZnC. Also liver and renal function parameters as well as the liver and kidney malondialdehyde (MDA) were elevated while antioxidant enzymes; catalase (CAT) and superoxide dismutase (SOD) were significantly (p < 0.05) reduced in PbC group in comparison with NC and ZnC. Concentrations of lead were in the order: blood > liver > kidney in the PbC group. In addition to restoration of the altered parameters, administration of zinc in Pb + Zn group significantly reduced the raised lead concentrations in the plasma and organs. Conclusion: Reduction in body Pb burden and restoration of Pb-induced derangements in haematological and biochemical parameters by Zn strongly support the ameliorative property of Zn against Pb-induced toxicity.

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“…Today, many sources of lead contamination were identified. These sources include water, air, and soil [6,12,13]. Increasing exposure to environmental lead has been attributed to recent industrialization and urbanization in some regions [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…These sources include water, air, and soil [6,12,13]. Increasing exposure to environmental lead has been attributed to recent industrialization and urbanization in some regions [13,14]. Recent studies have shown that plants and grains grown upon soils contaminated with lead contained elevated levels of this toxic heavy metal [10,15,16].…”

Section: Introductionmentioning

confidence: 99%

“…Previous studies investigated the use of several chelators to decrease toxicity in the incidents of exposure to lead [25]. Some of the previously used chelators were potentially toxic and could not be easily removed from tissues, thus, could present another risk to health [13,25]. In addition to its well-known antioxidant properties, ascorbic acid (vitamin C) is known to possess metal chelating activities [26].…”

Section: Introductionmentioning

confidence: 99%

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Sub-chronic treatment with high doses of ascorbic acid reduces lead levels in hen eggs intentionally exposed to a concentrated source of lead: a pilot study

Shawahna

Zyoud

Yahia

et al. 2020

BMC Pharmacol Toxicol

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Background: Hen eggs contaminated with lead can be harmful to the health of children and adults. The objective of this pilot study was to investigate if sub-chronic treatment with ascorbic acid can reduce lead levels in the different parts of hen eggs after intentionally exposing the laying hens to a concentrated source of lead. Methods: Clinically normal mixed-breed egg laying hens (n = 18) were used in this pilot study. Hens were exposed to a concentrated source of lead (200 mg/kg body weight /day lead acetate) for 1 week. Subsequently, egg laying hens were either treated with sub-chronic doses of ascorbic acid (500 mg/kg body weight /day) or left untreated for 4 weeks. Lead levels were assessed in eggshell , egg-albumen, and egg-yolk samples using a graphite furnace atomic absorption spectrophotometer. Results: Lead levels increased significantly (p-value < 0.01) from baseline in egg-yolk, egg-albumen, and eggshell samples following 1 week exposure to lead acetate. Sub-chronic treatment of egg laying hens with high doses of ascorbic acid could bring statistically significant reduction (p-value < 0.01) in lead levels in egg-yolk, egg-albumen, and eggshell samples after intentional exposure to a concentrated source of lead. Conclusions: Findings of this pilot study showed that sub-chronic treatment of egg laying hens with ascorbic acid can reduce lead levels in different egg parts after intentional exposure to a concentrated source of lead. Supplementing feedstuffs and water with sources of ascorbic acid could be beneficial in reducing lead levels in hen egg tissues following environmental exposure. Further studies are still required to investigate if ascorbic acid can reduce lead levels in other chicken tissues.

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Ameliorating effects of garlic, calcium, and vitamin C on chronic lead toxicity in albino rats

Cited by 7 publications

References 22 publications

Effect of LA on the Growth and Development of the Main Organs in Female Mice

Effect of LA on the Growth and Development of the Main Organs in Female Mice

Zinc ameliorates lead toxicity by reducing body Pb burden and restoring Pb-induced haematological and biochemical derangements

Sub-chronic treatment with high doses of ascorbic acid reduces lead levels in hen eggs intentionally exposed to a concentrated source of lead: a pilot study

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