Amelioration by the Natural Polyamine Spermine of Cartilage and Bone Destruction in Rats With Collagen-Induced Arthritis

Iezaki, Takashi; Hinoi, Eiichi; Yamamoto, Tomomi M.; Ishiura, Ryo; Ogawa, Shinya; Yoneda, Yukio

doi:10.1254/jphs.11241sc

Cited by 15 publications

(11 citation statements)

References 14 publications

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“…One study showed that daily supplementation of spermine significantly inhibited increases in the hind paw volume and arthritis score in collagen-induced arthritis rats. 23 Furthermore, a recent study evaluated the effects of dietary spermine supplementation on the inflammatory response in piglets. They showed that dietary spermine supplementation can alleviate inflammatory response by regulating the gene expression of signaling molecules related to inflammation.…”

Section: Discussionmentioning

confidence: 99%

Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever

Kim

Lee

Shin

et al. 2018

Lupus

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Systemic lupus erythematosus (SLE) is a systemic autoimmune disease with various clinical manifestations and serologic markers. In this study, we analyzed nine polyamine (PA) profiles of plasma from patients with SLE and healthy controls (HCs), and the relationship between the PA profiles and disease activity. PA alterations in plasma of 44 patients with SLE and fever were investigated using gas chromatography mass spectrometry (GC-MS) in selected ion monitoring mode using N-ethoxycarbonyl/ N-pentafluoropropionyl derivatives, and compared with those of 43 HCs. Patients with SLE and HCs showed differences in five of nine PA profiles. Among five changed PA levels, four PAs, namely N-acetylcadaverine, spermidine, N-acetylspermidine, and spermine, were dramatically decreased. However, the level of cadaverine was increased in patients with SLE. In the partial correlation with PA profiles and disease activity markers of SLE, several disease activity markers and nutritional markers were correlated with cadaverine, spermidine, and N -acetylspermidine. Thus, our results provide a comprehensive understanding of the relationship between PA metabolomics and disease activity markers in patients with SLE.

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Section: Discussionmentioning

confidence: 99%

Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever

Kim

Lee

Shin

et al. 2018

Lupus

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“…Other studies indicated that polyamines could instead be beneficial for RA. In fact, spermine ameliorated the destruction of cartilage and bone in the joints of CIA rats [ 120 ]. Moreover, both spermidine and spermine inhibited osteoclast differentiation in vitro and prevented bone loss in vivo in ovariectomized mice [ 121 ], an effect possibly due to the inhibition of migration of pre-osteoclasts during the fusion step [ 122 ].…”

Section: Arginine Metabolism and Ramentioning

confidence: 99%

Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe?

et al. 2020

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In mammals, amino acid metabolism has evolved to act as a critical regulator of innate and adaptive immune responses. Rheumatoid arthritis (RA) is the most common form of inflammatory arthropathy sustained by autoimmune responses. We examine here the current knowledge of tryptophan and arginine metabolisms and the main immunoregulatory pathways in amino acid catabolism, in both RA patients and experimental models of arthritis. We found that l-tryptophan (Trp) metabolism and, in particular, the kynurenine pathway would exert protective effects in all experimental models and in some, but not all, RA patients, possibly due to single nucleotide polymorphisms in the gene coding for indoleamine 2,3-dioxygenase 1 (IDO1; the enzyme catalyzing the rate-limiting step of the kynurenine pathway). The function, i.e., either protective or pathogenetic, of the l-arginine (Arg) metabolism in RA was less clear. In fact, although immunoregulatory arginase 1 (ARG1) was highly induced at the synovial level in RA patients, its true functional role is still unknown, possibly because of few available preclinical data. Therefore, our analysis would indicate that amino acid metabolism represents a fruitful area of research for new drug targets for a more effective and safe therapy of RA and that further studies are demanding to pursue such an important objective.

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“…It is well known that the use of polyamines in arthritis could be beneficial for synovial bearing reconstruction and reduce osteolytic activity (Iezaki et al, 2012). Moreover, continuous nociceptive stimulation caused by joint inflammation leads to spinal dorsal horn's neurons hyperexcitability inducing neuropathic pain (Fernihough et al, 2004;Lee et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

“…Regarding the root composition it has been reported the presence of alkaloids belonging to the spermidine group (Fu et al, 2008) together with the presence of stachydrine, a more polar alkaloid typical of the caper leaves too (Batanouny and Drissamnauer, 2005;Buckingham, 1994). Interestingly, the use of polyamine alkaloids, as those of the spermidine group, has been suggested as efficacious in arthritis disease (Iezaki et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Acute effect of Capparis spinosa root extracts on rat articular pain

Maresca

Micheli

Mannelli

et al. 2016

Journal of Ethnopharmacology

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a b s t r a c tEthnopharmacological relevance: Capparis spinosa L. originates from dry regions of Asia and Mediterranean basin. In traditional medicine of these areas, infusions from caper root are considered to be beneficial for the treatment of rheumatism, gout and against abdominal pains. Aim of the study: To evaluate the pain relieving properties of a Syrian cultivar of Capparis spinosa roots in rat models of osteoarthritis and rheumatoid arthritis. Materials and methods: Decoction (DEC) and hydroalcoholic extract (EtH 2 O) were obtained from powdered roots; the latter was further separated in CH 2 Cl 2 and aqueous (H 2 O-Res) fractions. The extracts were characterized in terms of spermidine alkaloids by HPLC/DAD/MS and stachydrine by NMR. Different amount of free and glycosilated forms of capparispine and analogues (from 0.5% w/w for DEC up to 7.6% w/w for CH 2 Cl 2 fraction) were detected. Rat models of rheumatoid arthritis and osteoarthritis were induced by the intra-articular administration of Complete Freund's Adjuvant (CFA) or monosodium iodoacetate (MIA), respectively. Results: Fourteenth days after CFA or MIA injection, the different preparations of Capparis spinosa (3, 30, 100 and 300 mg kg À 1 ) were acutely administered p.o.. Powdered roots (300 mg kg ) significantly reduced hypersensitivity to mechanical noxious stimuli as well as spontaneous pain evaluated as hind limb bearing alterations in both models. The CH 2 Cl 2 and the H 2 O-Res (30 mg kg À 1 ) were the most potent in reverting pain threshold alterations despite the different content of free alkaloids. Conclusions: Capparis spinosa extracts relieved pain related to rheumatoid arthritis and osteoarthritis after single administration. A synergistic effect due to a specific "phytochemical mixture" is suggested.

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Amelioration by the Natural Polyamine Spermine of Cartilage and Bone Destruction in Rats With Collagen-Induced Arthritis

Cited by 15 publications

References 14 publications

Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever

Polyamine patterns in plasma of patients with systemic lupus erythematosus and fever

Amino Acid Metabolism in Rheumatoid Arthritis: Friend or Foe?

Acute effect of Capparis spinosa root extracts on rat articular pain

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