AMELIORATION DE L’ACTIVITE ANTIBACTERIENNE DE Phyllanthus amarus (Euphorbiaceae) CONTRE Mycobacterium tuberculosis

Adebo, IB; Doumbia, I.; N, Aka; Dosso, Mireille; Guina, FG

doi:10.4314/asab.v8i1.43257

Cited by 2 publications

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“…The aqueous and ethanolic extracts of the leaves of Phyllantus amarus were inactive on P. aeruginosa and E. coli. These findings are in contrast to those of Adebo et al (1), who found a minimum bactericidal concentration (CMB) of 9.4 mg/mL, a minimum inhibitory concentration (MIC) of 9.4 mg/mL and A concentration for 50% inhibition (IC50) of 1.5 mg/mL with P. aeruginosa. A CMB of 18.7 mg/mL, a MIC of 9.4 mg/mL and an IC50=0.9 mg/mL were revealed with E. coli.…”

Section: Discussioncontrasting

confidence: 56%

Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

et al. 2018

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SummaryObjectives. This study aims to evaluate the antibacterial and chemical properties of some medicinal plants used in the fight against enteropathogens in Benin.Methods. Aqueous and ethanolic extracts of Senna siamea, Uvaria chamae, Lantana camara and Phyllantus amarus were tested on 10 bacterial strains. Well diffusion technique, coupled with the microdilution determination of Minimum Inhibitory Concentration (MIC) and Minimum Bactericidal Concentration (CMB) was used for antibacterial testing. The larval cytotoxicity was evaluated by using Artemia salina crustacean larvae. flavonoids and polyphenols were also assayed by the method using aluminum trichloride (AlCl3) and the method using the folin-Ciocalteu reagent, respectively.Results. The results of the study revealed that extracts had an effective antibacterial activity at 100 mg/mL, with MIC between 100 and 25 mg/mL and CMB between 100 and 50 mg/mL. The inhibition diameters of the extracts varied between 7.5 and 21 mm. The ethanolic extract of Phyllantus amarus leaves showed the best antibacterial activity. None of the extracts tested was found to be cytotoxic at the dose of 20 mg/mL. The aqueous Uvaria chamae root extract has the highest polyphenol content (231.896552±0.27586207 in μg EAG/100 mg extract), whereas the aqueous leaf extract of Uvaria chamae is the richest in flavonoids (41.061082 0.43180737 in μg ER/100 mg of extract).Conclusions. These interesting results can be used in the development of improved traditional medicines against enteropathogens. IntroductionInfections caused by enteropathogens are serious forms of infectious pathology. They are a major public health problem that causes millions of deaths a year. This is the case, for example, of foodborne illnesses, causing 17 million deaths a year worldwide, more than half of which come from the African continent (37). Diarrheal diseases are also the cause of 550 million patients each year, including 220 million children under 5 years of age (37). Salmonella, shigella and klebsielles are amongst others epidemiologically active enterobacteria involved in serious infectious diseases.Health management of enteropathogenic diseases is achieved through the use of antibiotics, but their inadequate and often anarchic use has resulted in bacterial resistance (24,36). Indeed, recent data from the bibliography abound with descriptions of bacteria that are multiresistant or even toto-resistant to antibiotics. The number of these bacteria is increasing in both industrialized and developing countries (32). This development of microbial resistance to antibiotics has led researchers to carry out alternative investigations to identify other effective natural remedies against various pathologies in the plant kingdom (18). It has therefore proved essential to look for new antibacterial substances that are effective and have a broad spectrum of action. One of the effective strategies for this research is to explore plants used in traditional Correspondence: Victorien T. Dougnon, Lecturer-Researcher in Microb...

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Section: Discussioncontrasting

confidence: 56%

Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

et al. 2018

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“…The homogenate was then filtered two times on absorbent cotton and once on Whatman N° 1 paper. This filtrate was dried in the oven at 40°C; the obtained powder is considered as the total aqueous extract ready to use for antimicrobial tests (Adebo et al, 2008).…”

Section: Aqueous Extractsmentioning

confidence: 99%

Antimicrobial activity of Anacardium occidentale L. leaves and barks extracts on pathogenic bacteria

Sika¹,

Sina²,

Adoukonou‐Sagbadja³

et al. 2014

Afr. J. Microbiol. Res.

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The aim of this study was to investigate the antibacterial activity of aqueous, ethanol, ethyl acetate and dichloromethane extracts of two different cashew tree parts (leaf and bark). The susceptibility of strains to the different extracts was evaluated in vitro by disc diffusion method on ten reference strains and nine foods strains. The minimum inhibitory concentrations (MIC) and minimum bactericidal concentrations (MBC) were determined respectively by macro-dilution method and seeding on solid medium. Among the four types of extracts, only the ethanol and ethyl acetate extracts of the two organs inhibited the growth of both bacteria and yeast. The MIC varies respectively between 0.039 and 0.625 mg/ml for reference strains and from 0.078 to 2.5 mg/ml for food isolated strains. Concerning MBC, it varies from 0.313 to 20 mg/ml for food isolated strains and from 0.078 to 20 mg/ml for reference strains. The ethanol and acetyl acetate extracts of the two cashew organs displays both a bacteriostatic and bactericidal effects on tested microorganisms. Our results suggest that extracts from cashew leaves may provide novel precursors for antimicrobial drug development research.

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AMELIORATION DE L’ACTIVITE ANTIBACTERIENNE DE Phyllanthus amarus (Euphorbiaceae) CONTRE Mycobacterium tuberculosis

Cited by 2 publications

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Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

Exploration of the antibacterial and chemical potential of some Beninese pharmacopoiea traditional plants

Antimicrobial activity of Anacardium occidentale L. leaves and barks extracts on pathogenic bacteria

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