Amelioration of 4-methylguaiacol on LPS-induced inflammation in THP-1 cells through NF-κB/IκBα/AP-1 and Nrf2/HO-1 signaling pathway

Zhao, Dong; Jiang, Yining; Sun, Jin; Li, He He; Sun, Xiaotang; Zhao, Mou Ming

doi:10.1016/j.jff.2019.01.047

Cited by 19 publications

(13 citation statements)

References 35 publications

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“…AP-1 is a redox-sensitive protein that can activate the transcription of many genes, including HO-1, and participate in the protective response to oxidative stress ( 34 ). One study on the upstream regulatory region of the HO-1 gene promoter identified multiple antioxidant response elements (AREs) in the region adjacent to AP-1 and NF-?β, and Nrf2 is the main nuclear transcription regulator that directly binds to AREs ( 35 ). Under normal conditions, Nrf2 binds to Keap1 in the cytoplasm and is in an inactive state.…”

Section: Discussionmentioning

confidence: 99%

Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice

Sha

Pan

et al. 2021

Front. Nutr.

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The aim of this study was to analyze the non-volatile composition and antioxidant differences of lemon essential oils (LEOs) obtained by cold-pressing vs. hydrodistillation. Pathological observations showed that LEO effectively inhibited liver injury caused by oxidative stress, and CPLEO was more effective than HDLEO. CPLEO increased serum T-AOC, SOD, GSH, and GSH-Px levels while decreasing NO, COX-2, IL-6, IL-1β, IFN-γ, and TNF-α levels in mice with oxidative damage. The effects of CPLEO were stronger than those of HDLEO and similar to those of vitamin C. CPLEO upregulated mRNA and protein expressions of Cu/Zn-SOD, Mn-SOD, CAT, HO-1, Nrf2, and NQO1 while downregulating nNOS, iNOS, IL-1β, COX-2, TNF-α, and NF-κB mRNA expression and nNOS, eNOS, iNOS, and COX-2 protein expression in mice with oxidative damage. The results demonstrate that LEO has good antioxidant effects and that CPLEO has a better antioxidant effect than HDLEO as it retains more active non-volatile substances.

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Section: Discussionmentioning

confidence: 99%

Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice

Sha

Pan

et al. 2021

Front. Nutr.

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“…On the other hand, oxidative stress caused by external factors can also activate nuclear factor kappa‐B (NF‐κB) and redox‐sensitive transcription factor activating protein‐1 (AP‐1) thus increase the expression of inflammatory cytokines (Rahman et al., 1999). Results in this study revealed that AAPH‐induced oxidative stress‐triggered inflammatory, which could promote the production of inflammatory cytokines, mediators, vasodilators, and accelerate cell damage in vivo (Zhao, Jiang, Sun, Li, Sun, et al., 2019). Antioxidant peptide AYI exhibited antioxidant activity especially upregulated the HO‐1 expression both on gene and protein levels.…”

Section: Resultsmentioning

confidence: 87%

Assessment of in vivo antioxidant activity of a tripeptide Ala‐Tyr‐Ile fromJiuzao(a by‐product of baijiu distillation) protein hydrolysates and its stability in baijiu

Jiang

Sun

Zhao

et al. 2020

J. Food Process. Preserv.

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Peptide Ala‐Tyr‐Ile (AYI) was isolated from Jiuzao protein hydrolysates and proved with antioxidant ability in vitro in the previous study. Considering the limitation in vitro, the antioxidant activity and potential mechanism in vivo of AYI were investigated by AAPH‐induced oxidative stress Sprague–Dawley (SD) rat model in this study. The results showed that AYI could activate Nrf2/Keap1‐p38/PI3K‐MafK signaling pathway both on gene and protein expressions. Meanwhile, AYI could markedly (p < .05) increase downstream antioxidant enzymes (i.e., CAT, GPx, SOD, and HO‐1) expressions and suppress the expressions of inflammatory factors (i.e., TNF‐α, IL‐1β, IL‐6, and NO). The results above indicated potential antioxidant and anti‐inflammatory activity in vivo of peptide AYI. In addition, AYI could also exist stably in baijiu after 14‐day storage. This study provides a better thought for the use of Jiuzao to isolate antioxidant peptides and enhance baijiu antioxidant function by adding these peptides in it. Practical applications Jiuzao is a by‐product of baijiu distillation, which is generally used as the forage of livestock. However, considering the raw material of baijiu distillation, nonvolatile components remain in Jiuzao, such as protein and peptides. Therefore, functional peptides can be extracted from Jiuzao. Peptide AYI was identified from Jiuzao protein hydrolysates and was proved with antioxidant ability in vitro. This study further explored its antioxidant capacity in vivo and proved it could be used as a natural ingredient for baijiu to enhance its antioxidant function. It can also contribute to pharmaceutical, cosmetic, and functional foods industry. In addition, other functional components in Jiuzao also deserve for exploring.

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“…Rice husk liquid smoke contains several types of phenolic compounds, in the form of 2-methoxyphenol (guaiacol), mequinol, phenol, and 4-ethylguaiacol, 11 which can increase the expression and activation of the Nrf2 signaling pathway 27 and inhibit the expression activation of the NF-kB/IkBα signaling pathway. 28…”

Section: Discussionmentioning

confidence: 99%

The Effects of Rice Husk Liquid Smoke in Porphyromonas gingivalis-Induced Periodontitis

et al. 2021

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Objectives The purpose of this study is to analyze the effects of rice husk liquid smoke in Porphyromonas gingivalis-induced periodontitis in the inflammatory and proliferation marker such as nuclear factor kappa β (NF-kB), tumor necrosis factor-α (TNF-α), interleukin-6 (IL-6), transforming growth factor-β (TGF-β), fibroblast growth factor 2 (FGF2), collagen type 1 (COL-1) expression, and the number of macrophages, lymphocytes, and fibroblasts. Materials and Methods Rice husk liquid smoke is obtained by the pyrolysis process. Porphyromonas gingivalis-induced periodontitis in 20 μL phosphate-buffered saline containing 1 × 109 CFU was injected into the lower anterior gingival sulcus of Wistar rats. The periodontitis was then treated with 20 μL/20 g body weight of rice husk liquid smoke once a day for 2 and 7 days, respectively. After treatment, the bone and lower anterior gingival sulcus were analyzed with immunohistochemistry and hematoxylin–eosin staining. Results The treatment of periodontitis with rice husk liquid smoke showed a lower NF-kB, TNF-α, and IL-6 expression and a higher TGF-β, FGF2, and COL-1 expression than the control after treatment for 2 and 7 days (p < 0.05), respectively. The number of macrophages and fibroblasts was also higher when compared with the control group (p < 0.05), but the number of lymphocytes was lower than the control (p < 0.05). Conclusion Rice husk liquid smoke showed its effects on Porphyromonas gingivalis-induced periodontitis with a decrease in inflammatory markers and an increase in proliferation markers. The development of a rice husk liquid smoke periodontitis treatment is promising.

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Amelioration of 4-methylguaiacol on LPS-induced inflammation in THP-1 cells through NF-κB/IκBα/AP-1 and Nrf2/HO-1 signaling pathway

Cited by 19 publications

References 35 publications

Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice

Effects of Cold-Pressing and Hydrodistillation on the Active Non-volatile Components in Lemon Essential Oil and the Effects of the Resulting Oils on Aging-Related Oxidative Stress in Mice

Assessment of in vivo antioxidant activity of a tripeptide Ala‐Tyr‐Ile fromJiuzao(a by‐product of baijiu distillation) protein hydrolysates and its stability in baijiu

The Effects of Rice Husk Liquid Smoke in Porphyromonas gingivalis-Induced Periodontitis

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