Amelioration of Cisplatin-Induced Kidney and Liver Damage in Rabbits by Fresh Carrot (Daucus carota L) Juice.

Abstract

The present study was carried out to investigate the protective effects of fresh carrot juice on Hepato renal injuries induced by a single intraperitoneal injection of cisplatin (CP) (5 mg/kg). The AST, ALT activities, and the levels of creatinine, urea were significantly (P < 0.05) increased in the serum of CP-treated rabbits (positive control) as compared to the normal rabbits (negative control). in contrast, Triglycerides and cholesterol concentrations were significantly decreased in the serum of CP-treated rabbits as compared to the normal rabbits. A dose of 5ml /kg body weight of fresh carrot juice was orally administered for 4 consecutive days before (CP) injection and 3 consecutive days after the (CP) injection reduced activities of AST, ALTand serum urea, serum creatinine levels which were altered by (CP), and succeeded in restoring of Triglycerides, cholesterol concentrations significantly to the normal range. On the other hand, histopathological Hepato renal tissue damage mediated by (CP) was greatly ameliorated by fresh carrot juice treatment. It was concluded that fresh carrot juice represents a potential therapeutic option to protect against (CP) Hepatorenal injuries commonly encountered in clinical practice.