Amelioration of diabetes and its complications by Manilkara zapota (L) P. Royen fruit peel extract and its fractions in alloxan and STZ-NA induced diabetes in Wistar rats

Karle, Pravin P.; Dhawale, Shashikant C.; Navghare, Vijay

doi:10.1007/s40200-022-01000-8

Cited by 2 publications

(1 citation statement)

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“…Several previous studies stated that the sapodilla plant has the potential to be used as an antihyperlipidemic drug , including the study conducted by Barbalho et al (2015) 15 which showed that Male rats were given the juice from the leaves or fruit of M. zapota for 50 days, and the results showed considerably decreased levels of glycemia, insulin, leptin, cholesterol, and triglycerides and increased levels of HDL-c in the treated rats. Another research that has been conducted by Karle et al (2022) 16 also shows that Manilkara fruit doses of 300 and 600 mg/kg showed significant antihyperglycemic effects, improved lipid profiles, increased body weight, and improved glomerulosclerosis.…”

Section: Introductionmentioning

confidence: 93%

The Effect of Sapodilla Leaf Extract (Manilkara zapota L.) on Lipid Profiles of Alloxan-Induced Diabetic Mice

Solikhah¹,

Wijaya²,

Salsabila³

et al. 2023

Pharmacogn J.

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Section: Introductionmentioning

confidence: 93%

The Effect of Sapodilla Leaf Extract (Manilkara zapota L.) on Lipid Profiles of Alloxan-Induced Diabetic Mice

Solikhah¹,

Wijaya²,

Salsabila³

et al. 2023

Pharmacogn J.

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The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features

2022

Biomolecules

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Diabetic nephropathy (DN) is a common complication of diabetes mellitus. While there has been a great advance in our understanding of the pathogenesis of DN, no effective managements of this chronic kidney disease are currently available. Therefore, continuing to elucidate the underlying biochemical and molecular mechanisms of DN remains a constant need. In this regard, animal models of diabetes are indispensable tools. This review article highlights a widely used rodent model of non-obese type 2 diabetes induced by nicotinamide (NA) and streptozotocin (STZ). The mechanism underlying diabetes induction by combining the two chemicals involves blunting the toxic effect of STZ by NA so that only a percentage of β cells are destroyed and the remaining viable β cells can still respond to glucose stimulation. This NA-STZ animal model, as a platform for the testing of numerous antidiabetic and renoprotective materials, is also discussed. In comparison with other type 2 diabetic animal models, such as high-fat-diet/STZ models and genetically engineered rodent models, the NA-STZ model is non-obese and is less time-consuming and less expensive to create. Given that this unique model mimics certain pathological features of human DN, this model should continue to find its applications in the field of diabetes research.

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Amelioration of diabetes and its complications by Manilkara zapota (L) P. Royen fruit peel extract and its fractions in alloxan and STZ-NA induced diabetes in Wistar rats

Cited by 2 publications

References 72 publications

The Effect of Sapodilla Leaf Extract (Manilkara zapota L.) on Lipid Profiles of Alloxan-Induced Diabetic Mice

The Effect of Sapodilla Leaf Extract (Manilkara zapota L.) on Lipid Profiles of Alloxan-Induced Diabetic Mice

The Nicotinamide/Streptozotocin Rodent Model of Type 2 Diabetes: Renal Pathophysiology and Redox Imbalance Features

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