Amelioration of Lipid Profile and Level of Antioxidant Activities by Epigallocatechin-gallate in a Rat Model of Atherogenesis

Xu, Xuelian; Pan, Jianxing; Zhou, Xiaoli

doi:10.1016/j.hlc.2014.05.013

Cited by 26 publications

(15 citation statements)

References 38 publications

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“…LDL concentrations between SHAM showed statistically differences with the OVX group (p<0.05). This suggests that the condition of hypoestrogen would increase LDL levels in the blood, this result similar with previous study (Xu et al, 2014). There was a significantly difference between tamoxifen and DOE groupg compared with OVX group (p<0.05).…”

Section: Discussionsupporting

confidence: 90%

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Effect of Dayak Onion (Eleutherine bulbosa (Mill.) Urb) on Uterine wall and Lipid Profiles of Ovariectomized Rat

Purnamasari

Bahtiar²

2018

OnLine Journal of Biological Sciences

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Menopause is a physiologic condition, in which women no longer experience menstruation. Decreased estrogen during and after menopause causes structural, physiological and biochemical changes that alter the health of women in general, both in organs and non-reproductive organs. Dayak onion contains eleuterinol, an naphtoqunone derivative that can be as SERM. Therefore, we evaluated the effects of dayak onions on lipid profiles and uterine wall. This study used female white rats of Sprague-Dawley. All groups, except the sham group, is ovariectomized to obtain the conditions of hypoestrogen. Rats were divided into 6 groups. SHAM (CMC Na 0,5%), OVX (CMC Na 0,5%), TAM (tamoxifen), DOE dose 1 (dayak onion extract 8 mg/200), DOE dose 2 (dayak onion extract 12 mg/200 g) and DOE dose 3 (dayak onion extract 18 mg/200 g). Mouse model of ovariectomy given 3 doses of extract, from giving each extract it was seen that the weight of uterine DOE dose 1, DOE dose 2 and DOE dose 3 respectively 55,24, 53,38 and 61,85 mg had lower uterine weight when compared with Positive control given tamoxifen 72.2 mg. The effects of onion on uterine weight reduction are greater than that of tamoxifen on the animal model menopause.

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Section: Discussionsupporting

confidence: 90%

“…Cholesterol, Triglyceride, LDL, HDL levels were determined by the enzymatic colorimetric method using kit (DiaSys, Germany) and evaluated using spectrophotometer UV-Vis Shimadzu 1800 (Japan) (Xu et al, 2014).…”

Section: Determination Of Lipid Profilesmentioning

confidence: 99%

Effect of Dayak Onion (Eleutherine bulbosa (Mill.) Urb) on Uterine wall and Lipid Profiles of Ovariectomized Rat

Purnamasari

Bahtiar²

2018

OnLine Journal of Biological Sciences

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“…Previous studies from our laboratory also depicted that upon EGCG administration to rats fed with HCD, alters the serum and hepatic lipid and lipoprotein parameters . EGCG administration resulted in significant decrease in lipids and lipoprotein parameters in rat model of atherogenesis . Consuming green tea extract regularly may lower LDL level more than 15% …”

Section: Discussionmentioning

confidence: 69%

EGCG exerts its protective effect by mitigating the release of lysosomal enzymes in aged rat liver on exposure to high cholesterol diet

Ravindran

Jaganathan

Kalaiselvi

2020

Cell Biochemistry & Function

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The aim is to test the hypothesis whether the cholesterol loaded lysosomes are capable of mediating lysosomal membrane permeabilization (LMP) during aging and to study the efficacy of epigallocatechin-3-gallate (EGCG) in preserving the lysosomal membrane stability. Aged rats were fed with high cholesterol diet (HCD) and treated with EGCG orally. Serum and tissue lipid status, cholesterol levels in lysosomal fraction, activities of lysosomal enzymes in lysosomal, and cytosolic fractions were measured. Transmission electron microscopic studies (TEM), oil red "O" (ORO) staining, and immunohistochemical analysis of oxidized low density lipoprotein (OxLDL) were carried out. Significant increase in serum, tissue lipid profile, and lysosomal cholesterol levels were observed in aged HCD-fed rats with a concomitant decrease in high density lipoprotein (HDL) levels. We also observed a significant increase in lipid accumulation in hepatocytes of aged HCD-fed rats by TEM, ORO, and immunohistochemical staining. Upon treatment with EGCG to aged HCD-fed animals, we found augmented levels of HDL with a concomitant decrease in lysosomal cholesterol levels and other lipoproteins. TEM studies and immunohistochemistry of OxLDL also showed a marked reduction in lipid deposition of hepatocytes. Thus, EGCG has preserved the lysosomal membrane stability in HCD stressed aged rats.Significance of the study: The research article is focused mainly on the effect of EGCG and its capability on mitigating the release of lysosomal enzymes in aged animals fed with HCD. The study signifies the cellular function of the organelle lysosome following administration of aged rats with HCD, which would make the readers to understand the action of EGCG and the interrelationship of both cholesterol and activity of lysosomes when cholesterol is loaded.

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“…Various preclinical human studies have confirmed the anti-obesity effects of green tea extracts [17][18][19]. The beneficial effects of green and cocoa teas have been attributed to catechins, particularly epigallocatechin gallate (EGCG) [20][21][22][23]. Various studies have found that cocoa tea supplementation dose-dependently downregulated the expression levels of genes controlling cholesterol uptake (LDL-R) and cholesterol synthesis (HMG Co-A reductase), and exhibited strong antioxidant activities [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Herbal antihyperlipidemic formulation of cocoa tea: Preparation and <i>in vivo</i> comparison with atorvastatin

Li¹,

Yang²,

Wang³

et al. 2017

Trop. J. Pharm Res

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Amelioration of Lipid Profile and Level of Antioxidant Activities by Epigallocatechin-gallate in a Rat Model of Atherogenesis

Cited by 26 publications

References 38 publications

Effect of Dayak Onion (Eleutherine bulbosa (Mill.) Urb) on Uterine wall and Lipid Profiles of Ovariectomized Rat

Effect of Dayak Onion (Eleutherine bulbosa (Mill.) Urb) on Uterine wall and Lipid Profiles of Ovariectomized Rat

EGCG exerts its protective effect by mitigating the release of lysosomal enzymes in aged rat liver on exposure to high cholesterol diet

Herbal antihyperlipidemic formulation of cocoa tea: Preparation and <i>in vivo</i> comparison with atorvastatin

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