Amelioration of neurotoxicity induced by esfenvalerate: impact of Cyperus rotundus L. tuber extract

Hussein, Jihan; Medhat, Dalia; Abdel-Latif, Yasmin; Morsy, Safaa; Gaafar, Alaa A.; Ibrahim, E. M.; Al-kashef, A. S.; Nooman, Mohamed U.

doi:10.1007/s00580-020-03182-0

Cited by 10 publications

(4 citation statements)

References 59 publications

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“…These results correlate with previously demonstrated data [ 63 , 64 ]. TN (50, 100 and 200 mg/kg) treatment managed to mitigate Scop-induced neuroinflammation, suggesting the significant anti-inflammatory activity of TN, which was also reported for other Cyperus species [ 46 ] in a dose-dependent manner. The decrease in the pro-inflammatory cytokines may also prevent the over-activation of the hippocampal cells, thus can diminish Aβ accumulation [ 59 ].…”

Section: Discussionsupporting

confidence: 64%

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The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

et al. 2022

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The aim of the present study is to investigate the phytochemical composition of tiger nut (TN) (Cyperus esculentus L.) and its neuroprotective potential in scopolamine (Scop)-induced cognitive impairment in rats. The UHPLC-ESI-QTOF-MS analysis enabled the putative annotation of 88 metabolites, such as saccharides, amino acids, organic acids, fatty acids, phenolic compounds and flavonoids. Treatment with TN extract restored Scop-induced learning and memory impairments. In parallel, TN extract succeeded in lowering amyloid beta, β-secretase protein expression and acetylcholine esterase (AChE) activity in the hippocampus of rats. TN extract decreased malondialdehyde levels, restored antioxidant levels and reduced proinflammatory cytokines as well as the Bax/Bcl2 ratio. Histopathological analysis demonstrated marked neuroprotection in TN-treated groups. In conclusion, the present study reveals that TN extract attenuates Scop-induced memory impairments by diminishing amyloid beta aggregates, as well as its anti-inflammatory, antioxidant, anti-apoptotic and anti-AChE activities.

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Section: Discussionsupporting

confidence: 64%

“…TN extract offers antioxidant [ 44 , 45 ], anti-inflammatory, neuroprotective [ 46 ] and beneficial effects in memory-related disorders [ 47 ]. Therefore, the aim of the present study was to investigate the protective effect of TN extract on Scop-induced memory impairment in rats.…”

Section: Discussionmentioning

confidence: 99%

The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

et al. 2022

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“…Jia et al [95] demonstrated that palmatine, another isoquinoline alkaloid, significantly enhanced the activity of the SOD3 gene responsible for antioxidant defenses in a specific worm model. Additionally, Hussein et al [96] studied the protective attributes of an alkaloid-rich extract from Cyperus rotundus L. (CR) against neurotoxicity in rats. They found that while exposure to the toxin esfenvalerate reduced brain PON1 levels, treatment with the C. rotundus extract notably countered this toxicity by elevating PON1 levels.…”

Section: Impact Of Alkaloid Extracts On Tos Tas and Osi Levels In Pc-...mentioning

confidence: 99%

Neuroprotective Potential of Isoquinoline Alkaloids from Glaucium grandiflorum Boiss. and A. Huet subsp. refractum (Nábelek) Mory: Role of NRF2-KEAP1 Pathway

Niğdelioğlu Dolanbay,

Şirin,

Aslim

2023

Applied Sciences

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The extracts of Glaucium grandiflorum have been used to treat neurodegenerative diseases. Nonetheless, no former study has investigated whether the alkaloid extracts of G. grandiflorum have antioxidative effects against oxidative stress. The aim of the present study was to determine the antioxidative effects of the alkaloid extracts of G. grandiflorum with a variety of targets and probable mechanisms. First, we used spectrophotometry to investigate alkaloid extracts with respect to their alkaloid amounts. Then, we determined the alkaloid extracts’ impact on thiol/disulfide homeostasis, total oxidant status/total antioxidant status/oxidative stress index, and antioxidant enzyme activities. Finally, the effects of alkaloid extracts on the genes in the NRF2-KEAP1 pathway were determined via qRT-PCR. We conducted molecular docking analyses to determine the potential binding of isoquinoline alkaloids found within the alkaloid extracts with target proteins. We observed the best results from chloroform alkaloid extract and methanol alkaloid extract. Chloroform alkaloid extract was prominent in DPPH radical scavenging and metal ions chelating, and methanol alkaloid extract showed significant hydroxyl radical scavenging, lipid peroxidation, and superoxide anion radical scavenging activity. Alkaloid extract groups substantially increased in total thiol activity, native thiol activity, disulfide activity, total antioxidant status level, antioxidant enzyme levels, and gene expression levels (GCLC, HO-1, NRF2, and NQO1) compared to the H2O2 group. Also, alkaloid extract groups led to a significant drop in total oxidant status level, oxidative stress index level, and KEAP1 gene expression level relative to the H2O2 group. According to our study results, oxidative stress brought about by H2O2 was regulated by alkaloid extracts. As a result, a phytochemical-based therapeutic that regulates H2O2-induced oxidative stress was brought to the neurochemical field.

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“…Several studies have reported the higher reduction capacity of the aqueous extracts from the plant C. rotundus (Safriani et al, 2016). Previous studies documented that C. rotundus with elevated levels and potent antioxidant compounds contribute significantly in ameliorating disorders caused by oxidative stress, including diabetes mellitus (Hussein et al, 2020;Jivad et al,2014).…”

Section: Adme (Absorption Distribution Metabolism and Excretion) Prop...mentioning

confidence: 99%

Antioxidative and antidiabetic activity and phytochemicals analysis of some selected Sudanese traditional medicinal plants.

Idris

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Amelioration of neurotoxicity induced by esfenvalerate: impact of Cyperus rotundus L. tuber extract

Cited by 10 publications

References 59 publications

The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

The Potential Neuroprotective Effect of Cyperus esculentus L. Extract in Scopolamine-Induced Cognitive Impairment in Rats: Extensive Biological and Metabolomics Approaches

Neuroprotective Potential of Isoquinoline Alkaloids from Glaucium grandiflorum Boiss. and A. Huet subsp. refractum (Nábelek) Mory: Role of NRF2-KEAP1 Pathway

Antioxidative and antidiabetic activity and phytochemicals analysis of some selected Sudanese traditional medicinal plants.

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