Amelioration of Obesity, Glucose Intolerance, and Oxidative Stress in High-Fat Diet and Low-Dose Streptozotocin-Induced Diabetic Rats by Combination Consisting of “Curcumin with Piperine and Quercetin”

Abstract

Curcumin is an important nutraceutical that has enormous potential for a variety of diseases, but the medicinal properties of curcumin cannot be utilized due to its low in vivo bioavailability. Therefore, in view of the foregoing, there is an extensive need for combinatorial extract “curcumin with piperine and quercetin” which may enhance bioavailability of oral curcumin by inhibiting the enzymes responsible for the metabolism of curcumin. Thus, the present study investigated the effect of combinatorial extract of curcumin on obesity, glucose intolerance, and oxidative stress in high fat diet and low-dose streptozotocin-induced rats. Oral administration of combinatorial extract for 28 days significantly (P < 0.05) reduced PGL (64.84%), PTG (88.94%), LDL (26.38%) and PTC (50.23%) levels, respectively and improved glucose tolerance (P < 0.05) significantly to exogenously administered glucose (2 g/kg) at 60, 90, and 120 min interval on OGTT. The results for antioxidant potential indicate that at 100 mg/kg dose of combinatorial extract of curcumin significantly prevented the high-fat diet and low-dose streptozotocin-induced changes in the oxidative stress parameters (P < 0.01) which supports popular medicinal uses of this combinatorial extract as antihyperglycemic and hypolipidemic and is likely to bring this promising natural product to the forefront of therapeutic agents in the in the treatment of “metabolic syndrome”.

Supplementation of Syzygium cumini seed powder prevented obesity, glucose intolerance, hyperlipidemia and oxidative stress in high carbohydrate high fat diet induced obese rats

“…Oxidative stress in rats due to high fat diet feeding also increases the glucose intolerance and insulin resistance [42, 43]. Our investigation also revealed that high fat diet increased plasma and tissues level of oxidative stress markers.…”

Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial

“…Literature review showed curcumin attracted increasing attention for the treatment of a range of conditions because of its numerous health benefits and people consuming curcumin in daily life have better health status [6,7,[36][37][38][39]. Due to side effects of chemical drugs, except in severe cases, chemical drugs consumption is not recommended for treating PMS.…”

Curcumin Protects Metronidazole and X-ray Induced Cytotoxicity and Oxidative Stress in Male Germ Cells in Mice

“…Since GSH is utilized for detoxification of free radicals, increased sensitivity to oxidative stress also occurs when cells are depleted of GSH (Chen et al, 1997;Kaur and Meena, 2012;Sehgal et al, 2012). Curcumin has been found to show promising increase in superoxide dismutase activity with comparable free radical scavenging ability and an improved antioxidant efficacy (Barik et al, 2005;Girish and Pradhan, 2012;Kaur and Meena, 2012;Sehgal et al, 2012). Curcumin thus is a potent dietary antioxidant against ROS and ROS induced cellular damage (Singh and Giri, 2012).…”