Amelioration of respiratory and circulatory changes in established endotoxic shock by ketoprofen

Abstract

In an intensive-care setting we studied the effects of ketoprofen, a dual inhibitor of cyclooxygenase and lipoxygenase, on circulatory and respiratory changes during established endotoxic shock in sheep. Two groups (n = 7 in each) were exposed to E. coli endotoxin, which caused a sharp increase in pulmonary artery pressure (200%; PAP), intrapulmonary shunt fraction (300%; QS/QT%), and oxygen extraction ratio (50%; VO2/DO2%). There was also a significant decrease in mean arterial pressure (25%; MAP), respiratory compliance (60%; CT), arterial oxygen tension (65%; PaO2), and oxygen delivery index (15%; DO2) in both groups. After 30 min of endotoxin infusion, group K received ketoprofen, 2.5 mg/kg b.w. i.v., while group E served as shock controls. After 4 h there had been a significant improvement in MAP, PaO2, DO2, QS/QT%, and CT in the ketoprofen-treated group compared with the controls (P < 0.01). In addition, the oxygen extraction ratio normalised in group K, but remained 70-100% increased in group E (P < 0.01). The wet-to-dry weight ratios of the lungs and the liver were significantly lower in the ketoprofen-treated group compared with the controls (P < 0.05). It was concluded that ketoprofen significantly ameliorated the respiratory and circulatory effects of established endotoxic shock in sheep.

Postanesthetic hyperthermia in cats: a retrospective comparison between hydromorphone and buprenorphine

“…Ketoprofen is a non‐steroidal anti‐inflammatory drug (NSAID) with analgesic, antipyretic and anti‐inflammatory properties (Sigurdsson & Youssef 1994). At the time this study was conducted, there were no licensed NSAIDs available for use in cats but ketoprofen was used in clinical practice (Dobbins et al.…”

Pharmacodynamics and pharmacokinetics of ketoprofen enantiomers in sheep

“…1,2 Ketoprofen contains a single asymmetric carbon atom and therefore exists in 2 enantiomeric forms (R(-) KTP and S(+) KTP). It possesses analgesic, antipyretic, anti-inflammatory, and antiendotoxemic properties that are characteristic of such compounds.…”

Non-steroidal Anti-inflammatory Analgesics for Acute Pain Management in Dogs and Cats

“…Prostaglandins also appear to have a powerful effect upon spinal nociceptive processing by facilitating the firing of central neurons and augmenting neurotransmitter release from primary spinal sensory afferents (5). Some NSAIAs inhibit both cyclooxygenase and lipoxygenase activity (6). Lipoxygenase also utilizes arachidonic acid as a substrate to produce the leukotriene group of inflammatory mediators.…”