Amelioration of vincristine neurotoxicity by glutamic acid

Jackson, Don V.; Wells, H. Bradley; Atkins, James N.; Zekan, Patricia J.; White, Dougľas R.; Richards, Frederick; Cruz, Julia M.; Muss, Hyman B.

doi:10.1016/0002-9343(88)90306-3

Cited by 94 publications

(43 citation statements)

References 18 publications

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“…pyridoxine and folinic acid, possess the potential to counteract VCR-induced neuropathy has been studied (Jackson et al, 1986a,b). Apart from a once-reported beneficial effect of glutamic acid, no significant counteraction has been established (Jackson et al, 1988). When severe neuropathy develops, VCR treatment has to be postponed or the dose has to be reduced.…”

mentioning

confidence: 99%

Effects of the ACTH(4-9) analogue, ORG 2766, on vincristine cytotoxicity in two human lymphoma cell lines, U937 and U715

Kiburg

Loosdrecht²,

Schweitzer³

et al. 1994

Br J Cancer

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Summary The use of cytotoxic drug vincristine (VCR) is limited by the occurrence of peripheral neuropathy. A neurotrophic ACTH(4-9) analogue, ORG 2766, is being studied for its protective effect. Possible modulatory effects of ORG 2766 on tumour cell growth and interference with the cytotoxic efficacy of VCR were studied in two human lymphoma cell lines, U937 and U715. The effects of ORG 2766 on cell growth and survival and on VCR-mediated cytotoxicity were investigated using two MTT-based assays to study direct cytotoxic effects and to assess residual growth after pretreatment. Treatment with ORG 2766 alone had no effect on cell growth and survival. Neither did this drug affect VCR cytotoxicity. However, after 96 h pretreatment with ORG 2766 and a culture period of 7 days, a reduction in residual growth and a potentiation of VCR-induced inhibition of growth capacity was observed in U715 cells, and to some extent also in U937 cells. It is concluded that ORG 2766 has no stimulatory effects on tumour growth and does not negatively interfere with VCR-mediated cytotoxicity. Rather it enhances the cytostatic effect of VCR. It is suggested that ORG 2766 can safely be used in clinical trials investigating the ability of ORG 2766 to counteract VCRinduced neurotoxicity.

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mentioning

confidence: 99%

Effects of the ACTH(4-9) analogue, ORG 2766, on vincristine cytotoxicity in two human lymphoma cell lines, U937 and U715

Kiburg

Loosdrecht²,

Schweitzer³

et al. 1994

Br J Cancer

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“…Glutamic acid, ORG-2766 (an adrenocorticotrophic hormone analogue) and noscapine have also been stated to protect against vincristine-induced neuropathy. Folinic acid has also been used successfully in a small number of vincristine overdosages in humans 13 15 16…”

Section: Discussionmentioning

confidence: 99%

Vincristine-induced unilateral ptosis with serendipitous response to modafinil

Revannasiddaiah

Bhattacharyya²

2011

Case Reports

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“…Support for the empiric treatment with glutamic acid to reduce neurotoxicity is suggested by the work of Jackson et al (1988) in breast cancer patients using vincristine in conventional doses intravenously. A competitive common transport mechanism between vincristine and glutamic acid was postulated.…”

Section: Discussionmentioning

confidence: 99%

Potential salvage therapy for inadvertent intrathecal administration of vincristine

et al. 1997

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Summary.Vincristine is an anti-neoplastic agent for intravenous use. Inadvertent intrathecal administration of vincristine tends to follow a predictable clinical sequence of a progressive ascending radiculomyeloencephalopathy, usually fatal in outcome. We report a case of a 10-year-old girl who suffered an inadvertent intrathecal vincristine administration. We have outlined the management strategy used and her consequent neurological progress. She has survived but with a significant neurological deficit. Her outcome is, however, less severe than in previous literature reports; this may in part be attributable to early aggressive neurological management. This case also serves to highlight the tragic consequences of human error when handling chemotherapeutic agents of this nature.

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Amelioration of vincristine neurotoxicity by glutamic acid

Cited by 94 publications

References 18 publications

Effects of the ACTH(4-9) analogue, ORG 2766, on vincristine cytotoxicity in two human lymphoma cell lines, U937 and U715

Effects of the ACTH(4-9) analogue, ORG 2766, on vincristine cytotoxicity in two human lymphoma cell lines, U937 and U715

Vincristine-induced unilateral ptosis with serendipitous response to modafinil

Potential salvage therapy for inadvertent intrathecal administration of vincristine

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