Ameliorative Actions of Garlic (Allium sativum) and Ginger (Zingiber 
 officinale) on Biomarkers of Diabetes and Diabetic Nephropathy in Rats: 
 Comparison to Aspirin

Thomson, Martha; Al-Qattan, Khaled; Juyal, Divya; Ali, Muslim

doi:10.3923/ijp.2013.501.512

Cited by 12 publications

(28 citation statements)

References 44 publications

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“…In the present study, STZ-injected rats developed a rapid hyperglycemia and hypoinsulinemia as shown previously by our group and others [ 44 – 46 ]. Treating diabetic rats with either 300 or 600 mg/kg dose of AGE significantly decreased blood glucose and markedly increased serum insulin.…”

Section: Discussionsupporting

confidence: 89%

“…In the current study, indicators of OS were assessed in serum as well as kidney and liver tissues of STZ-induced diabetic rats. As we have previously reported, anti-oxidants were decreased and OS was increased in serum, liver and kidneys of this experimental model of CD rats [ 31 , 44 ]. Treatment with either 300 or 600 mg/kg of AGE significantly increased the anti-oxidant defense systems as indicated by increased levels of total anti-oxidants and anti-oxidant enzymes and lowered lipid peroxidation in liver and kidney tissues.…”

Section: Discussionsupporting

confidence: 66%

See 1 more Smart Citation

Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats

Thomson

Al-Qattan

et al. 2015

BMC Complement Altern Med

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BackgroundAlthough aged garlic extract (AGE) shares some active components with fresh garlic and in spite of its palatability and milder side effects, the anti-diabetic and related anti-oxidant properties of AGE have not been investigated extensively, and the reported findings are inconsistent.This study investigated the anti-diabetic effects of 3 incremental doses of AGE in streptozotocin (STZ)-induced diabetic rats (fasting blood sugar > 20 mM).MethodDiabetic rats were divided into a control diabetic group (CD) and AGE-treated diabetic group (AGE-D). The AGE-D was divided into 3 groups and accordingly treated with AGE i.p. at 100, 300 and 600 mg/kg daily for 8 weeks. A control normal group (CN) was also included for reference.ResultsCompared to the CN group, the CD group showed significant loss of body weight (over 50 %); and decreased serum insulin concentration (10 fold) and total anti-oxidant level and catalase activity (45–70 %) in serum, kidney and liver. Conversely, the CD rats had an elevated blood glucose (nearly 4 fold), serum cholesterol (nearly 2 fold) and triglycerides (>2 fold), erythrocyte glycated hemoglobin (GHb, 3 fold) and kidney and liver lipid peroxidation (MDA levels). Treatment with AGE positively reversed the diabetic changes in the targeted parameters to levels significantly lower than those measured in the CD group and the degrees of attenuation were almost dose dependent especially with the two higher doses.ConclusionAGE exhibits a dose-dependent ameliorative action on indicators of diabetes in STZ-induced diabetic rats.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionsupporting

confidence: 66%

Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats

Thomson

Al-Qattan

et al. 2015

BMC Complement Altern Med

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“…The required volume of GE was thawed daily to ambient temperature before administration and following use any remaining amount was discarded. GC-MS comparative analysis of the GE after different times of freeze-storage showed similar composition and concentration of components [ 42 , unpublished data].…”

Section: Methodsmentioning

confidence: 99%

“…The induced hypotension may be mediated, in part, through a reduced AngII concentration resulting in lower vasoconstrictive action and/or indirectly through an increase in the amounts and actions of vasodilatory agents [ 41 ]. More recently, our group has also shown that GE treatment in early STZ-DM improved kidney clearance functions [ 42 ], in addition to preserving the normal expression and balance of the two AngII receptors types [ 43 , 44 ].…”

Section: Introductionmentioning

confidence: 99%

Garlic Attenuates Plasma and Kidney ACE‐1 and AngII Modulations in Early Streptozotocin‐Induced Diabetic Rats: Renal Clearance and Blood Pressure Implications

Al-Qattan

Thomson

Jayasree

et al. 2016

Evidence-Based Complementary and Alternative Medicine

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Raw garlic aqueous extract (GE) has ameliorative actions on the renin-angiotensin system in type-1 diabetes mellitus (DM); however its effects on plasma and kidney angiotensin I converting enzyme type-1 (ACE-1) and angiotensin II (AngII) require further elucidation. This study investigated the effect of GE on plasma and kidney ACE-1 and AngII concentrations and in relation to systemic and renal clearance indicators significant to blood pressure (BP) homeostasis in early streptozotocin- (STZ-) induced type-1 DM. Normal rats (n = 10) received 0.5 mL normal saline (NR/NS), diabetic rats (n = 10) received 0.5 mL NS (DR/NS), and treated diabetic rats (n = 10) received 50 mg/0.1 mL/100 g body weight GE (DR/GE) as daily intraperitoneal injections for 8 weeks. Compared to NR/NS, DR/NS showed a significant increase in plasma ACE-1 and AngII and conversely a decrease in kidney ACE-1 and AngII. These changes were associated with an increase in BP and clearance functions. Alternatively and compared to DR/NS, DR/GE showed normalization or attenuation in plasma and kidney ACE-1 and AngII. These GE induced rectifications were associated with moderation in BP elevation and renal clearance functions. Garlic attenuates modulations in plasma and kidney ACE-1 and AngII, in addition to BP and renal clearance function in type-1 DM.

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“…Those combinations have been popular due to their minimal side-effects, potential efficacy and synergistic actions [21]. Treatment of diabetic rats with a blend of ginger and garlic showed reduced glycated haemoglobin (GHb) levels in erythrocytes of treated rats [22]. The aqueous extract of a blend of Aloe vera gel and cinnamon bark was reported to have an obvious antioxidant properties with accelerated wound healing effects in diabetic rats [23].…”

Section: Introductionmentioning

confidence: 99%

Fast disintegrating tablets of spray dried poly-herbal extract: a promising hypoglycemic and diabetic wound healing activity.

Mahran

Hussein

Ahmed

et al. 2020

Journal of advanced Biomedical and Pharmaceutical Sciences

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Many herbal products have been used to control blood glucose level and minimize complications of diabetes mellitus. However, the feasibility of using such herbal product has been hindered due to the lower stability of their extracts and patients incompliance. Objective: An optimized fast disintegrating tablet preparation of spray dried aqueous extract of poly herbal blend has been formulated to maximize the therapeutic activity of such herbal extract. Methods: different ratios of superdisintegrants were evaluated in terms of reducing disintegration time and wetting time of the prepared formulations. The potential of the optimized formula in reducing blood glucose level and promoting wound healing in streptozotcin (STZ)-induced diabetic rats was determined. Key finding: Oral administration of the optimized formula (F6) had significant superior effect in reducing blood glucose level and promoting wound healing of diabetic rats compared receiving the aqueous extract of the herbal blend (P<0.05, p<0.01, respectively). That may be attributed to the enhanced stability and the accurate dosing of such solid dosage form. In addition, no remarkable toxic manifestations or histologic changes were observed in treated animals. Conclusion: These findings uncover the potential of the formulated dosage form in enhancing the hypoglycemic and wound healing activity of the herbal extract.

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Ameliorative Actions of Garlic (Allium sativum) and Ginger (Zingiber officinale) on Biomarkers of Diabetes and Diabetic Nephropathy in Rats: Comparison to Aspirin

Cited by 12 publications

References 44 publications

Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats

Anti-diabetic and anti-oxidant potential of aged garlic extract (AGE) in streptozotocin-induced diabetic rats

Garlic Attenuates Plasma and Kidney ACE‐1 and AngII Modulations in Early Streptozotocin‐Induced Diabetic Rats: Renal Clearance and Blood Pressure Implications

Fast disintegrating tablets of spray dried poly-herbal extract: a promising hypoglycemic and diabetic wound healing activity.

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