Garlic Attenuates Plasma and Kidney ACE‐1 and AngII Modulations in Early Streptozotocin‐Induced Diabetic Rats: Renal Clearance and Blood Pressure Implications

Al-Qattan, Khaled; Thomson, Martha; Jayasree, Divya; Ali, Muslim

doi:10.1155/2016/8142394

Cited by 10 publications

(3 citation statements)

References 64 publications

(85 reference statements)

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“…Garlic shows powerful effects in DM, such as hypoglycemia, hyperinsulinemia, hypotriglyceridemia, anti-glycation, hypocholesterolemia, and anti-lipidperoxidation effects [116,117] (Figure 2). Garlic, either dried or fresh, and its derivatives show antihyperglycemic effects in genetic animal models of DM [116,134,135,136,137] and clinically in humans [138,139]. Garlic improves insulin sensitivity and the associated metabolic syndrome in animal models [134], and its derivatives reduce both insulin resistance [67] and blood glucose in streptozotocin-induced and alloxan-induced DM mellitus in rats and mice [140,141].…”

Section: Oscs From Garlic As Nutraceuticals For Prevention and Thementioning

confidence: 99%

Natural Hydrogen Sulfide Donors from Allium sp. as a Nutraceutical Approach in Type 2 Diabetes Prevention and Therapy

2019

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Type 2 diabetes mellitus (DM) is a socially relevant chronic disease with high prevalence worldwide. DM may lead to several vascular, macrovascular, and microvascular complications (cerebrovascular, coronary artery, and peripheral arterial diseases, retinopathy, neuropathy, and nephropathy), often accelerating the progression of atherosclerosis. Dietary therapy is generally considered to be the first step in the treatment of diabetic patients. Among the current therapeutic options, such as insulin therapy and hypoglycemic drugs, in recent years, attention has been shifting to the effects and properties—that are still not completely known—of medicinal plants as valid and inexpensive therapeutic supports with limited side effects. In this review, we report the relevant effects of medicinal plants and nutraceuticals in diabetes. In particular, we paid attention to the organosulfur compounds (OSCs) present in plant extracts that due to their antioxidant, hypoglycemic, anti-inflammatory, and immunomodulatory effects, can contribute as cardioprotective agents in type 2 DM. OSCs derived from garlic (Allium sp.), due to their properties, can represent a valuable support to the diet in type 2 DM, as outlined in this manuscript based on both in vitro and in vivo studies. Moreover, a relevant characteristic of garlic OSCs is their ability to produce the gasotransmitter H2S, and many of their effects can be explained by this property. Indeed, in recent years, several studies have demonstrated the relevant effects of endogenous and exogenous H2S in human DM, including by in vitro and in vivo experiments and clinical trials; therefore, here, we summarize the effects and the underlying molecular mechanisms of H2S and natural H2S donors.

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Section: Oscs From Garlic As Nutraceuticals For Prevention and Thementioning

confidence: 99%

Natural Hydrogen Sulfide Donors from Allium sp. as a Nutraceutical Approach in Type 2 Diabetes Prevention and Therapy

2019

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“…Cystathionine γ -lyase-derived H 2 S affects lipoprotein synthesis, insulin sensitivity, and mitochondrial biogenesis, in which tissue-specific regulation pathway might be a promising therapeutic target of diabetes and other metabolic syndromes [ 144 ]. The ameliorative action of organopolysulfides in garlic on the elevated blood pressure and renal clearance functions in diabetes may be mediated through attenuating modulations in plasma and kidney angiotensin I converting enzyme type-1 and angiotensin II concentrations; thiosulfinate in garlic is a promising agent for the management of postprandial hyperglycemia [ 145 , 146 ].…”

Section: Major Mechanisms and Structural Activity Of Alliums Compomentioning

confidence: 99%

Therapeutic Role of Functional Components in Alliums for Preventive Chronic Disease in Human Being

Zeng

Yang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

109

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Objectives. Functional components in alliums have long been maintained to play a key role in modifying the major risk factors for chronic disease. To obtain a better understanding of alliums for chronic disease prevention, we conducted a systematic review for risk factors and prevention strategies for chronic disease of functional components in alliums, based on a comprehensive English literature search that was conducted using various electronic search databases, especially the PubMed, ISI Web of Science, and CNKI for the period 2007–2016. Allium genus especially garlic, onion, and Chinese chive is rich in organosulfur compounds, quercetin, flavonoids, saponins, and others, which have anticancer, preventive cardiovascular and heart diseases, anti-inflammation, antiobesity, antidiabetes, antioxidants, antimicrobial activity, neuroprotective and immunological effects, and so on. These results support Allium genus; garlic and onion especially may be the promising dietotherapeutic vegetables and organopolysulfides as well as quercetin mechanism in the treatment of chronic diseases. This review may be used as scientific basis for the development of functional food, nutraceuticals, and alternative drugs to improve the chronic diseases.

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“…The antidiabetic efficacy of Z. officinale rhizomes have been reviewed [2,3]. The efficacy of A. sativum cloves against diabetes and diabetes-induced complications have also been variously reported [4][5][6]. However, the available reports deal with raw rhizomes or cloves or extract there from.…”

Section: Introductionmentioning

confidence: 99%

An herbal formulation containing Zingiber officinale rhizomes and Allium sativum cloves can increase oral glucose tolerance in mice

Saha¹,

Rohani²,

Rayhana³

et al. 2017

Biol Eng Med

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Zingiber officinale rhizomes and Allium sativum cloves are two plant parts widely consumed in Bangladesh as spices, and which are readily available and affordable. The two plants also have ethnomedicinal uses, one of which uses being to treat diabetes. Since the plant parts are consumed in culinary dishes (which involves boiling or steaming), the objective of this study was to determine whether methanol extract of steamed Z. officinale rhizomes (MEZO) and steamed A. sativum cloves (MEAS) can both individually as well as more so in combination improve glucose tolerance in oral glucose tolerance tests (OGTT) in mice. Administration of either MEZO or MEAS to mice at a dose of 400 mg per kg body weight led to reductions in blood glucose levels in glucose-challenged mice by 37.0 and 34.9%, respectively. Administration of a combination of (MEZO + MEAS) at individual doses of 100, 200 and 400 mg each led to dose-dependent reductions in blood glucose levels, respectively, by 22.5, 30.4, and 42.2%. Thus, the two extracts demonstrated a synergistic effect when administered in combination. A standard antihyperglycemic drug, glibenclamide, when administered at a dose of 10mg per kg lowered blood glucose level by 43.9%. Thus, at the highest dose tested, the combination of the two extracts lowered blood glucose levels in a comparable manner to that of glibenclamide. Since the extracts were prepared from steamed plant parts, the results suggest that partaking of the two spices in culinary dishes can be effective in controlling blood glucose in diabetic patients.

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Garlic Attenuates Plasma and Kidney ACE‐1 and AngII Modulations in Early Streptozotocin‐Induced Diabetic Rats: Renal Clearance and Blood Pressure Implications

Cited by 10 publications

References 64 publications

Natural Hydrogen Sulfide Donors from Allium sp. as a Nutraceutical Approach in Type 2 Diabetes Prevention and Therapy

Natural Hydrogen Sulfide Donors from Allium sp. as a Nutraceutical Approach in Type 2 Diabetes Prevention and Therapy

Therapeutic Role of Functional Components in Alliums for Preventive Chronic Disease in Human Being

An herbal formulation containing Zingiber officinale rhizomes and Allium sativum cloves can increase oral glucose tolerance in mice

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