Ameliorative effect of Aloe gel against L-T4-induced hyperthyroidism via suppression of thyrotropin receptors, inflammation and oxidative stress

Panda, Sasmita; Sharma, Rajesh; Khan, Aysha; Kar, Anand

doi:10.1007/s11033-020-05405-7

Cited by 9 publications

(7 citation statements)

References 37 publications

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“…As a result of a feedback loop involving the hypothalamic-pituitary-thyroid axis, the anterior lobe of the pituitary gland is stimulated to produce more TSH in an effort to compensate for the decreasing thyroid gland function, leading to an increase in TSH following oral methimazole administration. A hormone that is structurally similar to TSH reduces TSH levels, this was demonstrated by Panda et al (2020), who also demonstrated that thyroid hormones are linked to nuclei. T4 levels rise, which impacts hypothalamic cells, while TSH levels fall, which affects pituitary cells.…”

Section: Thyroid Hormonesmentioning

confidence: 82%

“…Thyroid tissue is damaged and activity drops because of its impacts on lipids, proteins, and nucleic acids, which are crucial components of cells (SOD, GST, and CAT). It damages cell membranes by oxidizing fat-soluble unsaturated fatty acids, say Panda et al (2020). As a consequence of its regulatory qualities and ability to control thyroid hormone release, the drug raises thyroid hormone levels through a negative feedback mechanism.…”

Section: Thyroid Hormonesmentioning

confidence: 99%

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Study the Effect of Allicin Nanoparticles In Thyroid Activity in Hyperthyroidism Experimental Induced Female Rats

Al-Marmadhi,

Al-Gnami

2024

AAVS

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The present study has been designed to investigate impact of allicin nanoparticles on female rats with induction of the hyperthyroidism. Fifty mature female rats (aged 90 days and weighted 150±10 g) have been randomly assigned to 5 equal groups (10 each),control (C) group , T1,T2,T3 and T4 groups were drenched with thyroxine (300mg/kg of B.W for 28 days ) for hyperthyroidism induction, T2 was drenched with methimazole (2.5 mg/kg of B.W for 30 days), T3 was drenched with allicin nanoparticles (50 mg/kg of B.W for 30 days) and T4 was drenched with methimazole and allicin nanoparticles for 30 days. The results showed a significant increase in thyroid hormones (triiodothyronine (T 3 ) and thyroxine (T 4 )) and iodine levels in T1 as compared with control group while decreasing these parameters in T2, T3 and T4 as compared with T1. Thyroid stimulating hormone (TSH) decrease in T1 while increase in T2,T3 and T4. The histopathological changes in thyroid gland showed normal thyroid tissue in control group whereas, in T1 thyroid tissue showed normal with dilated thyroid follicles and it contains colloid in their lumen. T2 showed small in thyroid follicles size and empty for colloid with hyperplasia of epithelial cells. T3 showed high dilation of thyroid follicles with large amount of colloid . we can conclud that allicin nanoparticles at dose 50 mg/kg of B.W appears to enhance its bioavailability and effectiveness combating oxidative stress associated with hyperthyroidism.

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Section: Thyroid Hormonesmentioning

confidence: 82%

Section: Thyroid Hormonesmentioning

confidence: 99%

Study the Effect of Allicin Nanoparticles In Thyroid Activity in Hyperthyroidism Experimental Induced Female Rats

Al-Marmadhi,

Al-Gnami

2024

AAVS

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“…As thyroid hormone receptors belong to nuclear receptor family, so saponins can alter thyroid hormone activity by binding to these receptors [25]. Quercetin, naringenin, p-coumaric acid, cinnamic acid and scopoletin are known to possess thyroid inhibitory properties [26].…”

Section: Plants and Thyroid Dysfunctionmentioning

confidence: 99%

Insight into Therapeutic Role of Plant-derived Medicines in Thyroid Dysfunction

Jabeen

2021

AJBSR

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Endocrine disorders are very common in Asia of which the thyroid dysfunction (TD) represents a major subset. The prevalence of TD is rising to an alarming rate. The thyroid gland (TG) is morphologically a butterfly-shaped organ, located anterior to the trachea, just inferior to the larynx and flanked by wing-shaped left and right lobes with the medial region called isthmus. TG produces thyroid hormones (TH), mainly triiodothyronine (T3) and thyroxine (T4). TH action is mediated by multiple TH receptors belonging to a nuclear receptor superfamily that also includes receptors for other small lipophilic hormones. TH receptors function by binding to specific TH-responsive sequences in promoters of target genes and by regulating transcription. Regulation of TH is followed by the hypothalamic-pituitary-thyroid axis. TD can be due to overproduction or under production of TH; i.e. hyperthyroidism and hypothyroidism respectively. Hyperthyroidism is characterized by weight loss, heat intolerance, palpitation, increased sweating, warm soft skin, increased heart rate and blood pressure. Whereas; in hypothyroidism, the facial expressions become dull, the voice becomes husky, speech is slow, the eyes and face become puffy. Hormone replacement therapy has been a standard approach to TD. However, herbal approach for the treatment of thyroid dysfunction is gaining popularity as it is proved to be effective, safe and devoid of any or at least lesser side effects. According to the world health organization (WHO), about three-quarters of the world population depends upon natural remedies, including herbal medicine. Plants possess several secondary metabolites like phenols, phenolic acids, flavonoids, alkaloids, tannins, quinones, coumarins, saponins, terpenoids, triterpenoids, glycosides and organic acids, which affect thyroid dysfunction by different mechanisms. Therefore, this review aims to provide comprehensive information regarding various herbal drugs used in the management of thyroid dysfunction.

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“…The use of natural products or medicinal plant materials to treat thyroid problems has yet to be investigated. It has been observed that many plants that exhibit tyrosine in their constituents are considered responsible for the production of thyroid hormones [triiodothyronine (T 3 ) and vera, 9 Hippophae rhamnoides, 10 Luffa acutangula, 11 and Abutilon indicum 12 were previously reported. Similarly, several herbaceous plants from the Cholistan Desert (Pakistan) are used to treat different illnesses.…”

Section: ■ Introductionmentioning

confidence: 99%

“…It has been observed that many plants that exhibit tyrosine in their constituents are considered responsible for the production of thyroid hormones [triiodothyronine (T 3 ) and T 4 ]. Plants with antihyperthyroidism potential, such as Ficus racemosa, Aloe vera, Hippophae rhamnoides, Luffa acutangula, and Abutilon indicum were previously reported.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Sesuvium sesuvioides Using High-Performance Liquid Chromatography and Validation of Its In Vivo Anti-hyperthyroidism Effect via Suppressing Oxidative Stress and Inflammatory Markers

Sajid-ur-Rehman,

Ishtiaq,

Khan

et al. 2023

ACS Omega

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Ameliorative effect of Aloe gel against L-T4-induced hyperthyroidism via suppression of thyrotropin receptors, inflammation and oxidative stress

Cited by 9 publications

References 37 publications

Study the Effect of Allicin Nanoparticles In Thyroid Activity in Hyperthyroidism Experimental Induced Female Rats

Study the Effect of Allicin Nanoparticles In Thyroid Activity in Hyperthyroidism Experimental Induced Female Rats

Insight into Therapeutic Role of Plant-derived Medicines in Thyroid Dysfunction

Characterization of Sesuvium sesuvioides Using High-Performance Liquid Chromatography and Validation of Its In Vivo Anti-hyperthyroidism Effect via Suppressing Oxidative Stress and Inflammatory Markers

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