Ameliorative effect of camel's milk and Nigella Sativa Oil against thioacetamide-induced hepatorenal damage in rats

Ahmad, Aftab; Sadath, Saida; Ali, Soad Shaker; Abuzinadah, Mohammed F.; Alhadrami, Hani A.; Alghamdi, Anwar A.; Aseeri, Ali H; Khan, Shah Alam; Husain, Asif

doi:10.4103/pm.pm_132_17

Cited by 17 publications

(9 citation statements)

References 21 publications

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“…Combination of these hepatoprotective drugs showed synergistic effect and utilized for the treatment of liver disorder. Hence, in current study, we experimentally established efficacy of synthetic drug metformin along with Nigella sativa oil in liver and kidney disorder in comparison with standard reference to marketed polyherbal formulation "jigreen" based on our previous research work [1,6,29,30].…”

Section: Biomedical Research 2018; 29 (15): 3106-3116mentioning

confidence: 99%

“…Therefore, there is an urgent need of developing effective natural and synthetic drugs for the prevention and treatment of liver and kidney diseases. Based on the studies reported for N. sativa seeds possessing numerous therapeutic effects and on the reports of prophetic traditions that N. sativa seeds cure all diseases except death [29], this study was designed to carry out its comparative study along with metformin which also has diverse medicinal properties and is widely used in the management of chronic type-2 diabetes apart from several beneficial effects ranging from antitumor effect, anti-aging effect, cardiovascular protective effect, and Neuro-protective effect etc. [31].…”

Section: Biomedical Research 2018; 29 (15): 3106-3116mentioning

confidence: 99%

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Comparative biochemical and histopathological studies on the efficacy of metformin and Nigella sativa oil against thioacetamide-induced acute hepatorenal damage in rats

Ahmad¹,

Alkreathy²

2018

biomedicalresearch

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Background: Metformin is the first-line oral anti-diabetic drug and Nigella sativa (NS) have been used as traditional medicine to cure/prevent a wide range of diseases in different part of the world, particularly in Saudi Arabia. Objective: To carry out the comparative biochemical and histopathological studies on the efficacy of metformin, Nigella sativa oil (NSO) against thioacetamide (TAA)-induced acute hepatorenal damage in rats. Materials and methods: Forty-eight male Albino Wistar rats were randomly divided in to eight groups with six rats in each group. Group-I (normal control): received normal saline (1 ml/kg, p.o.), group II (toxic control): received normal saline (1 ml/kg, p.o.) and TAA (500 mg/kg, i.p.), group-III (NSO per se): NSO (2 ml/kg, p.o.), group IV (metformin per se): metformin (250 mg/kg/d, p.o.), group V (NSO+TAA): NSO (2 ml/kg/d p.o.)+TAA (500 mg/kg, i.p.): group VI (metformin+TAA): metformin (250 mg/kg/d, p.o.) +TAA (500 mg/kg, i.p.). Group VII (NSO+metformin +TAA): NSO (2 ml/kg, p.o.), and metformin (250 mg/kg/d, p.o.)+TAA (500 mg/kg, i.p.), group VIII (TAA+Jigreen): jigreen (1 ml/kg/d, p.o.)+TAA (500 mg/kg, i.p.). Normal saline, NSO, metformin and jigreen were administered to respective groups by gastric intubation for 7 consecutive days. On the 7 th d, 1 h after the drugs treatment, a single intraperitoneal injection of TAA (500 mg/kg,) was administered to the rats of all groups except groups I, III and IV to induce acute liver and kidney injury. All animals were sacrificed under ether anesthesia after 24 h of TAA administration. The liver and kidney function tests in the serum were evaluated to assess the toxic effects of TAA as well as the protective effects of the given treatments against TAA induced the hepatorenal toxicity. Histopathology of liver and kidney tissues was also carried out to validate the findings of biochemical investigation. Results: The results indicated that the TAA intoxicated rats showed significant increase in the alanine transaminase (ALT), aspartate transaminase (AST), gamma-glutamyl transpeptidase (GGT), alkaline phosphatase (ALP), lipid profile, uric acid, urea, creatinine, while no significant changes were observed in serum levels of calcium, magnesium and phosphorus as compared with normal control rats. In the treatment groups, combination drug therapy showed remarkable alleviation of hepatorenal toxicity in metformin plus NSO group and was congruent to that of the standard polyherbal preparation "jigreen". The histopathological studies also support the hepatorenal protective effects of metformin and NSO. Conclusion: The results of the study demonstrated that metformin+NSO protects liver and kidney against acute TAA toxicity. Overall, this study proved the ameliorative effects of metformin, NSO and metformin plus NSO combination against TAA induced hepatorenal toxicity in rats.

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Section: Biomedical Research 2018; 29 (15): 3106-3116mentioning

confidence: 99%

Section: Biomedical Research 2018; 29 (15): 3106-3116mentioning

confidence: 99%

Comparative biochemical and histopathological studies on the efficacy of metformin and Nigella sativa oil against thioacetamide-induced acute hepatorenal damage in rats

Ahmad¹,

Alkreathy²

2018

biomedicalresearch

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“…Nigella sativa L. is a small perennial plant long up to 20 to 90 cm and comes under the Ranunculaceae family [1] . It is mostly found in southern Europe, North Africa and Southeast Asia and cultivated in various countries in the world like the Middle Eastern, Mediterranean region, South Europe, India, Pakistan, Syria, Turkey, Saudi Arabia [2,3] The seeds of the plant are considered as a spice and also known as black seed.…”

Section: Introductionmentioning

confidence: 99%

Nigella sativa (Kalonji): A Black Seed of Miracle

Thakur¹,

Kaurav²,

Chaudhary³

2021

Int J Res Rev

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It is recommended by the World health organization (WHO) that most of the world's population depends on herbal medicine for their health care. Nigella sativa is commonly known as a Black seed, Black cumin or 'Habbatul Barakah' i.e. an annual herb possessing a wide range of medicinal uses apart from its commercial significance as a spice yielding plant. It has long been used in the folk medicine system of the Arabian Gulf region, Far East Asia, and Europe. Seeds and oils of N. Sativa are the primary medicinal source from ancient times. It is one of the most common herbal plants used worldwide and possesses various chemical constituents such as thymoquinone, thymohydroquinone, dithymoquinone, thymol, nigellicine, carvacrol, nigellicine, nigllimine, nigellidine, and alpha-hederin. There are more than 100 constituents isolated from the plant. These chemical compounds have many pharmacological activities such as antibacterial, antiviral, anti-inflammatory, wound healing effect and also for acne vulgaris, skin cancer, pigmentation and many other cosmeceutical properties. Much scientific research on N. sativa has been conducted over the last five decades to investigate chemical and pharmacological properties. In this review, the phytochemicals, pharmacological properties, Ayurvedic properties and folk uses of Nigella sativa are briefly explained. Keywords: Nigella sativa, Kalonji, Antinephrotic, Immunomodulary, Black cumin.

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“…It is also used in the management of psoriasis and cancers [32]. Recently, N. sativa was reported to exert protection against several food toxicants and ease the side effects of chemotherapeutic drugs including bromobenzene, tartrazine, cisplatin, thioacetamide and tramadol [33][34][35][36][37][38]. Potent antioxidants and anticancer agents in the plants including thymoquinone are well-documented [39].…”

Section: Introductionmentioning

confidence: 99%

Ethanol extract of Nigella sativa has antioxidant and ameliorative effect against nickel chloride-induced hepato-renal injury in rats

et al. 2020

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Background: Nickel exposure causes hepato-renal toxicity via oxidative stress. Medicinal plants with antioxidants properties are being explored as treatment options. In this study, the effect of ethanol extract of Nigella sativa (ENS) on nickel chloride (NiCl 2)-induced hepato-renal damage was evaluated by monitoring biochemical and oxidative stress markers. Additionally, the antioxidant capacity and phytochemical constituents of ENS were quantified using HPLC and GC-MS. Result: NiCl 2 significantly increased (p < 0.05) aspartate aminotransferase, creatinine, sodium ion, chloride ion and malondialdehyde levels, while antioxidant enzymes were decreased in the organs except for kidney glutathione-Stransferase when compared to the control. However, ENS exerted inhibitory effect against NiCl 2 toxicity in both organs by reversing the biomarkers towards control levels. ENS has a high antioxidant capacity and is rich in antioxidants including gallic acid, quercetin, eucalyptol and levomenthol that may have accounted for the improvement of hepato-renal health in co-exposed rats. Conclusion: Our result suggests that amelioration of nickel chloride-induced hepato-renal pathology by ethanol extract of Nigella sativa was related to its antioxidant properties. Therefore, Nigella sativa could be valuable in the management of nickel-induced toxicity.

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Ameliorative effect of camel's milk and Nigella Sativa Oil against thioacetamide-induced hepatorenal damage in rats

Cited by 17 publications

References 21 publications

Comparative biochemical and histopathological studies on the efficacy of metformin and Nigella sativa oil against thioacetamide-induced acute hepatorenal damage in rats

Comparative biochemical and histopathological studies on the efficacy of metformin and Nigella sativa oil against thioacetamide-induced acute hepatorenal damage in rats

Nigella sativa (Kalonji): A Black Seed of Miracle

Ethanol extract of Nigella sativa has antioxidant and ameliorative effect against nickel chloride-induced hepato-renal injury in rats

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