Ameliorative effect of curcumin against lead acetate–induced hemato-biochemical alterations, hepatotoxicity, and testicular oxidative damage in rats

Abdelhamid, Fatma; Mahgoub, Hebatallah A.; Ateya, Ahmed

doi:10.1007/s11356-020-07718-3

Cited by 64 publications

(57 citation statements)

References 77 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Ceylan et al (2020) demonstrated that CAPE decreased MDA levels and increased SOD and CAT levels in testicular damage induced by cisplatin. In addition, Abdelhamid et al (2020) showed that curcumin decreased MDA levels in lead-induced testicular toxicity and significantly increased SOD, reduced glutathione (GSH) and CAT activity compared with the lead group. However, they reported that these results were only significant for MDA levels (Abdelhamid et al, 2020).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Abdelhamid et al (2020) showed that curcumin decreased MDA levels in lead-induced testicular toxicity and significantly increased SOD, reduced glutathione (GSH) and CAT activity compared with the lead group. However, they reported that these results were only significant for MDA levels (Abdelhamid et al, 2020). In our study, we found that MDA levels in the DOX group were increased both in serum and testicular samples compared with the other groups.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

et al. 2020

View full text Add to dashboard Cite

Testicular dysfunction is one of the serious side effects of cytotoxic chemotherapy. It has been reported that low sexual function and quality of life and infertility concerns associated with gonadal insufficiency in young patients are related to psychosocial distress (Levi et al., 2015). Doxorubicin (DOX, brand name Adriamycin), which is one of the most important cornerstones of many chemotherapeutic protocols, is an anticancer drug selected in the treatment of many chemo-responsive tumours from ovarian, breast, liver and lung cancer and lymphomas. However, DOX can cause severe dose-dependent toxicity for other nontarget tissues, including testicular tissues (e.g. reduced testicular weight; Nishi et al., 2018). Studies have reported that DOX toxicity causes testicular damage and apoptosis and adversely affects reproductive function (Kopalli et al., 2016; Nowrouzi et al., 2019). In addition, DOX has been reported to increase oxidative stress by reducing antioxidant capacity in testicular tissue (Uyeturk et al., 2014). Does DOX cause testicular toxicity by only increasing oxidative stress and apoptosis? Or does DOX have an effect on testicular

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Numerous edible plants are known to possess antioxidant properties, as they are rich in phytoantioxidants, namely phenolic compounds, flavonoids, etc. 1 , 26 , 29 . These natural antioxidants may improve metal mobilization from the body, reduce the dose of potential toxic chelators, and restrict the redistribution of toxic metal from one organ to another 30 .…”

Section: Introductionmentioning

confidence: 99%

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Shaban

El-Kader

Mogahed

et al. 2021

Sci Rep

View full text Add to dashboard Cite

Lead (Pb) toxicity is one of the most prevalent causes of human neurotoxicity. The available chelator drugs used now have many adverse effects. So, in this study, the protective role of Betavulgaris juice (BVJ) on rat neurotoxicity induced by Pb was evaluated and the results were compared with the results of dimercaptosuccinic acid (DMSA, as used drug). Additionally, the synergistic effect of BVJ and DMSA against Pb-induced neurotoxicity was assessed. The study focused on the determination of the antioxidant, anti-inflammatory, and neurological potential of BVJ (alone, and with DMSA) towards lead-induced neurotoxicity. Also, the characterization of BVJ was studied. The results showed that BVJ contains considerable quantities of polyphenols, triterpenoids, and betalains which play an important role as antioxidants and anti-inflammatory. BVJ exhibited a protective effect against neurotoxicity via the reduction of Pb levels in blood and brain. Moreover, BVJ decreased the oxidative stress, inflammation, and cell death induced by Pb. Also, BVJ regulated the activities of acetylcholine esterase and monoamine oxidase-A which changed by Pb toxicity. BVJ and DMSA combination displayed a synergistic antineurotoxic effect (combination index ˂ 1). These results were in harmony with brain histopathology. Conclusion: BVJ has a powerful efficacy in the protection from brain toxicity via diminishing Pb in the brain and blood circulation, resulting in the prevention of the oxidative and inflammatory stress. Treatment with BVJ in combination with DMSA revealed a synergistic effect in the reduction of neurotoxicity induced by Pb. Also, the antioxidant and anti-inflammatory effects of the BVJ lead to the improvement of DMSA therapy.

show abstract

“…Thrombo cytopenia with the overall increase in leukogram indices, particularly All values are given as µg g -1 . leukocytes (41%) and lymphocytes (55%) suggested an inflammatory type of leukogram, which is characterized by a rapid transient thrombocytopenia (Baskett et al, 1997) and leukocyte production (Abdelhamid et al, 2020). Earlier studies emphasized the damaging potential of aluminum (Chmielnicka et al, 1994) to the structure of RBCs by binding to proteins and enzymes that alter their activity and cause hemolysis (Engwa et al, 2019).…”

Section: The Hemogrammentioning

confidence: 99%

Acute and Chronic Effects of Aluminum Smelter Dust on Hematology, Metal Bioaccumulation and Oxidant-antioxidant Status in Rat

Adham

Asiri

2020

ASD

View full text Add to dashboard Cite

Background: Aluminum smelting industry is implicated with documented health risks. This study examined toxic effects of aluminum smelting dust as a real-life chemical hazard instead of single aluminum compounds, which seldom exist in real life. Methods: Adult male rats were gavaged acute (3 consecutive days) and chronic (6 weeks) doses of two dust concentrations (10 and 20 mg kg-1). Experimental investigation included toxic metal accumulation and biochemical analysis of blood and liver. Result: Aluminum and iron were highest in dust and respectively accumulated in brain, liver and kidneys. Anemia, inflammation, liver and kidney damage and oxidative stress were established in view of thrombocytopenia (35%), leukocytosis (41%), lymphocytosis (55%) and alterations in aminotransferases, creatinine, malondialdehyde, superoxide dismutase and catalase. Aluminum facilitation of iron-mediated lipid peroxidation is suggested. These findings drew attention to the magnitude (dose-dependent) and persistence (time-dependent) of aluminum dust as health compromising and are of particular significance to workers in aluminum smelting industries.

show abstract

Ameliorative effect of curcumin against lead acetate–induced hemato-biochemical alterations, hepatotoxicity, and testicular oxidative damage in rats

Cited by 64 publications

References 77 publications

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

Comparison of the protective effects of curcumin and caffeic acid phenethyl ester against doxorubicin‐induced testicular toxicity

Synergistic protective effect of Beta vulgaris with meso-2,3-dimercaptosuccinic acid against lead-induced neurotoxicity in male rats

Acute and Chronic Effects of Aluminum Smelter Dust on Hematology, Metal Bioaccumulation and Oxidant-antioxidant Status in Rat

Contact Info

Product

Resources

About