Ameliorative effect of fermented Pentaclethra macrophylla (African oil bean seed) on high fat diet and sucrose drink induced metabolic syndrome in male New Zealand rabbits.

Abstract

The consumption of nutraceuticals has become progressively popular in improving health, as well as disease treatment and prevention. The aim of this study is to evaluate the ameliorative effect of fermented Pentaclethra macrophylla (African oil bean) seed on high fat diet and sucrose drink induced metabolic syndrome in male New Zealand rabbits. All experimental procedures were carried using standard methods. A total of twenty (20) rabbits were used for this study, the animals were randomly grouped into five (5) groups with four (4) animals each. Metabolic syndrome risk factors obesity, hypertension, dyslipidemia and hyperglycemia were determined. HFD+30%SUC had over 1500g body weight (bwt) and fasting blood sugar (FBS) 239.50±5.74 mg/dl relative to the normal control with 1000±6.73g and 77.00±5.94 respectively whereas ND+30%SUC had lower FBS (l172.50±2.52) compared to HFD+30%SUC. There was a significant p<0.05 increase in body weights in treated groups with 1274±11.19g, 1282.75±4.99g, 1285±4.76g and FBS levels in mg/dL198.25±4.79, 198.75±8.06, 200±3.74 in rabbits compared to untreated HFD+30%SUC. Glycated hemoglobin, and ?-Amylase were significantly p<0.05 elevated, glucose-6-phosphate dehydrogenase levels were significantly p<0.05 reduced, lipid profile markers (HDL, TRIG & CHOL), electrolytes (sodium, potassium, calcium), urea and creatinine levels were significantly p<0.05 altered in HFD+30%SUC exposed group relative to the normal control and ND+30%SUC. However, dietary supplementation with fermented Pentaclethra macrophylla seeds caused weight, FBS, serum lipid reduction and potentiated electrolyte, urea and creatinine levels. Therefore, according to our results, fermented Pentaclethra macrophylla seed is an excellent nutraceutical and its consumption should be encouraged in modifying high fat and elevated intake of sucrose in rabbit

Evaluation of In vitro Anti-Diabetic Properties of Biosynthesized Magnesium Oxide Nanoparticles from Vernonia amygdalina (Bitter Leaf) Aqueous Leaf Extract

“…1cm 3 extracts was put in a test tube and approximately 2 drops of 5% FeCl3 were added. A greenish precipitate signifies the presence of phenolic.…”

“…0.5g powdered sample boiled in 20cm 3 water was filtered and ferric chloride (0.1%) was added dropwise to observe brown-green or blue-black color.…”

“…Type 2 diabetes mellitus can also be called adult-onset diabetes. Type 2 diabetic patients are always resistant to the action of insulin [3]. About 5-7% of the world's population suffers this type of diabetes and it is usually managed via dietary therapy, exercise and hypoglycemic agents [3].…”