Ameliorative effect of <i>Azadirachta indica</i> on sodium fluoride-induced hypertension through improvement of antioxidant defence system and upregulation of extracellular signal regulated kinase 1/2 signaling

Omóbòwálé, Temidayo Olutayo; Oyagbemi, Ademola Adetokunbo; Alaba, Bukola; Ola‐Davies, Olufunke Eunice; Adejumobi, Olumuyiwa Abiola; Asenuga, Ebunoluwa Racheal; Ajibade, Temitayo Olabisi; Adedapo, Adeolu Alex; Yakubu, Momoh Audu

doi:10.1515/jbcpp-2017-0029

Cited by 15 publications

(8 citation statements)

References 45 publications

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“…Ethanol treated rats (Group B) showed marked mucosal lesion of stomach and ileum whereas Group C showed significant regenerative properties in ethanol induced mucosal damage (Ofusoria, Falanab, Ofusoric, & Caxton-Martinsa, 2010). Methanolic extract administered to rats exhibited significant reduction in hypertension and genotoxicity induced by sodium fluoride (Omόbὸwálé et al, 2017). Summary of toxicological studies is shown in Table 6.…”

Section: Antifertility Activitymentioning

confidence: 99%

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Saleem

Muhammad

Hussain

et al. 2018

Phytotherapy Research

128

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Azadirachta indica L. is a multipurpose medicinal tree of family Meliaceae. It occurs in tropical and semitropical regions of the world. Different parts of this miraculous tree are used to treat pyrexia, headache, ulcer, respiratory disorders, cancer, diabetes, leprosy, malaria, dengue, chicken pox, and dermal complications. The tree is popular for its pharmacological attributes such as hypolipidemic, antifertility, microbicidal, antidiabetic, anti-inflammatory, hepatoprotective, antipyretic, hypoglycemic, insecticidal, nematicidal, antiulcer, antioxidant, neuroprotective, cardioprotective, and antileishmaniasis properties. A. indica is also rich in various phytochemicals for pharmaceuticals such as alkaloids, steroids, flavonoids, terpenoids, fatty acids, and carbohydrates. The fungicidal potential of the tree is due to the presence of azadirachtin and nimbin. Herein, we have compiled a comprehensive review of phytochemical profile, pharmacological attributes, and therapeutic prospective of this multipurpose tree.

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Section: Antifertility Activitymentioning

confidence: 99%

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Saleem

Muhammad

Hussain

et al. 2018

Phytotherapy Research

128

View full text Add to dashboard Cite

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“…Again, several human studies have found that exposure to excessive F is closely associated with hypertension [546,547,548,549,550]. Similar observations have been observed in experimental studies with rodents [551,552,553,554,555,556]. Interestingly, activation of the TRH system, with increased production of TRH and an upregulation of its receptors has also been implicated in the pathogenesis of hypertension [557].…”

Section: Discussionmentioning

confidence: 64%

“…Increasing evidence also suggests that maternal iodine deficiency and hypothyroidism is associated with increased risk of cognitive impairment, neurodevelopmental and neuropsychiatric disorders in offspring including ADHD [511,512,513,514,515,516,517,518,519,520,521,522,523,524,525,526,527,528,529,530,531,532,533,534,535,536,537,538,539,540,541,542,543,544,545,546,547,548,549,550,551,552,553,554,555,556,557,558,559,560,561,562,563,564,565], ASD [566,567,568], behavioural seizures [517] and schizophrenia [516]. Moreover, maternal iodine deficiency and hypothyroidism is also associated with increased risk of asthma [518] and hypertension [569] in offspring.…”

Section: Discussionmentioning

confidence: 99%

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

Waugh¹

2019

IJERPH

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In this study, several lines of evidence are provided to show that Na + , K + -ATPase activity exerts vital roles in normal brain development and function and that loss of enzyme activity is implicated in neurodevelopmental, neuropsychiatric and neurodegenerative disorders, as well as increased risk of cancer, metabolic, pulmonary and cardiovascular disease. Evidence is presented to show that fluoride (F) inhibits Na + , K + -ATPase activity by altering biological pathways through modifying the expression of genes and the activity of glycolytic enzymes, metalloenzymes, hormones, proteins, neuropeptides and cytokines, as well as biological interface interactions that rely on the bioavailability of chemical elements magnesium and manganese to modulate ATP and Na + , K + -ATPase enzyme activity. Taken together, the findings of this study provide unprecedented insights into the molecular mechanisms and biological pathways by which F inhibits Na + , K + -ATPase activity and contributes to the etiology and pathophysiology of diseases associated with impairment of this essential enzyme. Moreover, the findings of this study further suggest that there are windows of susceptibility over the life course where chronic F exposure in pregnancy and early infancy may impair Na + , K + -ATPase activity with both short- and long-term implications for disease and inequalities in health. These findings would warrant considerable attention and potential intervention, not to mention additional research on the potential effects of F intake in contributing to chronic disease.

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“…To support the antioxidant effect of the extract through enhanced GSH level, tissue non-protein thiol (NPT) level was also elevated significantly. Although the GSH is the major NPT in the cell [25], other forms of NPT like N-acetyl-cysteine (NCSH) and taurine are important intracellular antioxidants [26,27,28]. Similarly, pre-treatment of rats with CO extract reduced the tissue level of MDA a marker of oxidative stress associated with lipid peroxidation [29].…”

Section: Discussionmentioning

confidence: 99%

Corchorus olitorius Extract Attenuate Isoproterenol-Induced Cardiac Injury via Inhibition of Oxidative Stress, Arrhythmia and Pro-Apoptotic Protein Bax Expression

Alabi

Omóbòwálé

Oyagbemi

et al. 2020

JOCAMR

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Background and Aim: Corchorus olitorius (CO) leaf was reported to possess abundant antioxidants and used in the traditional treatment of heart disease. Previous studies revealed the protective roles of antioxidants against oxidative stress and inflammation, which are important underlying pathogenesis of myocardial injury that leads to infarction and heart failure. Therefore, CO leaf was chosen to evaluate its cardio-protective effects against ischemic-induced myocardial injury. Materials and Methods: Thirty male rats (Wistar strains) were divided into five groups (n = 6): normal control group, myocardial injury control group, pretreatment groups (250 and 500 mg/kg), positive control group (10 mg/kg enalapril). After pre-treatment of rats with ethanol leaf extract of CO for 19 days, Isoprenaline (100 mg/kg) administration induced acute myocardial injury and parameters like blood pressure, electrocardiogram, lipid peroxidation, antioxidants were assessed and tissue subjected to histological evaluations. Results: Isoproterenol given through subcutaneous significantly (p<0.05) reduced blood pressure and electrocardiography showed reduced p-interval and prolongation of QRS-interval in rats. The extract significantly increased the blood pressure and p-interval, QRS-interval were significantly reduced. The significant increase in tissue malondialdehyde, serum myeloperoxidase, creatine kinase-MB, lactate dehydrogenase and expression of Bax in the infarction control rats was decreased (p<0.05) in pre-treatment rats. Pre-treatment also increased glutathione-s-transferase, reduced glutathione and non-protein thiol level significantly. In contrast to cardio-injury control, histology showed mild level of inflammation and fatty infiltration in pre-treated rats. Conclusion: This study showed the protective role of ethanol extract of CO against myocardial injury through anti-apoptotic, antioxidant, anti-inflammatory and anti-arrhythmic effect.

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Ameliorative effect of Azadirachta indica on sodium fluoride-induced hypertension through improvement of antioxidant defence system and upregulation of extracellular signal regulated kinase 1/2 signaling

Abstract: This study shows the protective effect of AI on NaF-induced hypertension and genotoxicity through antioxidant and ERK 1/2 signaling in rats.

Cited by 15 publications

References 45 publications

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

A comprehensive review of phytochemical profile, bioactives for pharmaceuticals, and pharmacological attributes of Azadirachta indica

Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (Na+, K+-ATPase) Enzyme Activity: Molecular Mechanisms and Implications for Public Health

Corchorus olitorius Extract Attenuate Isoproterenol-Induced Cardiac Injury via Inhibition of Oxidative Stress, Arrhythmia and Pro-Apoptotic Protein Bax Expression

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