Ameliorative effect of naringin against doxorubicin-induced acute cardiac toxicity in rats

Kwatra, Mohit; Kumar, Vikas; Jangra, Ashok; Mishra, Murli; Ahmed, Sahabuddin; Ghosh, Pranab; Vohora, Divya; Khanam, Razia

doi:10.3109/13880209.2015.1070879

Cited by 74 publications

(67 citation statements)

References 67 publications

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“…32,62,63,65 The naringin treatment reduced the catalase activity in the mouse liver which is in agreement with the earlier studies where a similar effect has been reported. 32,[63][64][65] Both the treatment of naringin before or after DOX administration was equally effective in raising the catalase activity in mouse liver in the present study. Likewise, Aegle mamrmelos extract attenuated the doxorubicin-induced alleviation in the catalase activity of mice heart.…”

Section: Discussionsupporting

confidence: 81%

“…32,[61][62][63] Naringin treatment has been found to elevate the GSH concentration in the heart and liver of doxorubicin treated mice and rats. 32,[63][64][65] Similarly, extract of Agele marmalos has been reported to elevate myocardial glutathione in mice. 62 Glutamine an amino acid has been reported to protect against the DOX-induced depletion in GSH in rats.…”

Section: Discussionmentioning

confidence: 99%

“…32,62,63 Naringin treatment has been reported to inhibit the DOX induced reduction in the SOD activity in heart and liver of mice and rats. 32,[63][64][65] Similarly, naringin also suppressed the belomycin-induced decline in the SOD activity. 43 Phytic acid and wheat germ oil have been found to arrest the doxorubicin-induced decline SOD activity in rat liver, kidney and spleen.…”

Section: Discussionmentioning

confidence: 99%

“…DOX treatment has been earlier reported to increase the lipid peroxidation in rat and mice. 32,[61][62][63][64][65]72 Naringin treatment has been found to protect mouse and rat liver and heart against the DOX-induced lipid peroxidation. 32,[63][64][65] Naringin has also been reported to protect against iron and bleomycin-induced lipid peroxidation in earlier studies.…”

Section: Discussionmentioning

confidence: 99%

“…32,[61][62][63][64][65]72 Naringin treatment has been found to protect mouse and rat liver and heart against the DOX-induced lipid peroxidation. 32,[63][64][65] Naringin has also been reported to protect against iron and bleomycin-induced lipid peroxidation in earlier studies. 40,41,43 Similarly L-glutamine has been also reported to protect against the DPX-induced lipid peroxidation.…”

Section: Discussionmentioning

confidence: 99%

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Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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Doxorubicin a photosensitive antibiotic is frequently used to treat various malignancies in clinics; however, doxorubicin is also taken up by the normal cells of the body leading to increased oxidative stress and subsequently DNA damage and dysfunction in the cells. The agents which can reduce the adverse effect of doxorubicin will of great value. The present study has attempted to study the effect of naringin a citrus flavonoid on the doxorubicininduced oxidative stress in mice liver. The mice were administered with 0, 1, 5 or 10mg/ kg body weight of doxorubicin and treated with 10mg/kg body weight of naringin before or after doxorubicin treatment. The glutathione concentration and lipid peroxidation and activities of glutathione-s-transferase, catalase and super oxide dismutase were studied at 0.5, 1, 2 and 4h post-treatment in the mouse liver. The doxorubicin increased the lipid peroxidation in a dose dependent manner at all the post treatment times. Conversely, it attenuated the activities of glutathione-s-transferase, catalase and super oxide dismutase in dose dependent fashion and time dependent manner. A similar effect was observed for glutathione concentration. Treatment of mice with naringin before or after doxorubicin treatment elevated all the antioxidants and reduced the doxorubicin -induced lipid peroxidation. The effect of naringin pretreatment was more effective when compared to its post treatment. The naringin was very effective in reducing the oxidative stress induced by doxorubicin as indicated by the elevated levels of glutathione concentration, glutathiones-transferase, catalase and super oxide dismutase. The pretreatment of naringin was better than its post treatment.

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Section: Discussionsupporting

confidence: 81%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 3 more Smart Citations

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Ch¹,

Jagetia²,

Lalrinengi³

2017

MOJAP

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A Hierarchical Structured Ultrafine Fiber Device for Preventing Postoperative Recurrence and Metastasis of Breast Cancer

et al. 2020

Adv Funct Materials

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The high incidence of postoperative recurrence and metastasis has a serious effect on survival in breast cancer patients. Moreover, it is still a great challenge to prevent the postoperative recurrence and metastasis through traditional implantable devices due to their inability to control multiple drug release. Herein, an implantable hierarchical structured ultrafine fiber device with a time-programmed drug release function for the local postoperative adjuvant chemotherapy of breast cancer is developed. The structure is obtained through a co-axial electrospinning technology by the formation of the periodically arranged chambers inside a fiber matrix. The Doxorubicin hydrochloride in these chambers is released rapidly, killing the residual tumor cells to prevent tumor recurrence; while the matrix metalloproteinases-2 (MMP-2) inhibitor disulfiram in the fiber matrix is released in a sustained manner, inhibiting tumor invasion to prevent its metastasis. The fiber device implanted in tumor-bearing mice after a surgical tumor reduction displays excellent therapeutic efficacy by preventing both recurrence and metastasis. The mechanism investigation of tumor invasion through the type-II collagen immunofluorescence analysis reveals that the decrease of the activity of MMP-2 plays a key role in this process.

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Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis in Swiss Albino mice

Islam

Shree

Khan

et al. 2022

J Biochem & Molecular Tox

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Lung cancer, one of the most common cancer is a cause of concern associated with cancer‐related mortality. Benzo[a]pyrene [B(a)P], a potent carcinogen as well as an environmental contaminant is reported to be found in cigarette smoke among various sources. The present study focuses on the chemopreventive potential of Diosmin against B[a]P‐induced lung carcinogenesis and its possible mechanism in male Swiss Albino mice (SAM). SAM were treated orally with Diosmin (200 mg/kg b.w.) for 16 weeks and/or B[a]P (50 mg/kg b.w) for a period of 4 weeks. B[a]P treated cancerous mice showed increased peroxidation of membrane lipid as well as a decrease in the level/activity of antioxidant proteins. Cancerous mice also showed an increased level of carcinoembryonic antigen (CEA) and neuron‐specific enolase (NSE). Diosmin treatment, however, leads to decreased peroxidation of lipids, increased antioxidant proteins as well decrease in the level of CEA and NSE. B[a]P‐induced cancerous animals also exhibited increased expression of cyclic AMP response element‐binding protein (CREB), COX2 as well as prostaglandin‐E2 (PGE2) while Diosmin‐treated mice were found to have an ameliorative effect. Histopathological results further confirm the protective effect of Diosmin in averting B[a]P‐induced pathological alterations of lung tissue. Overall, our results suggest Diosmin exerts its chemopreventive potential possibly via targeting the CREB/cyclooxygenase‐2 (COX‐2)/PGE2 pathway thereby repressing inflammation.

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Ameliorative effect of naringin against doxorubicin-induced acute cardiac toxicity in rats

Cited by 74 publications

References 67 publications

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

Treatment of Mice with Naringin Alleviates the Doxorubicin-Induced Oxidative Stress in the Liver of Swiss Albino Mice

A Hierarchical Structured Ultrafine Fiber Device for Preventing Postoperative Recurrence and Metastasis of Breast Cancer

Chemopreventive potential of Diosmin against benzo[a]pyrene induced lung carcinogenesis in Swiss Albino mice

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