Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats

Bhutada, Pravinkumar; Mundhada, Yogita; Bansod, Kuldeep; Bhutada, Chetan; Tawari, Santosh; Dixit, Pankaj; Mundhada, Dharmendra

doi:10.1016/j.nlm.2010.06.008

Cited by 142 publications

(91 citation statements)

References 69 publications

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“…Quercetin (QU), for instance, had an antioxidative ability to eliminate free radicals and could ameliorate cognitive and memory dysfunction. [9][10][11][12] However, problems, including low solubility in the blood, rapid metabolism in the intestine and liver, and low uptake in the brain, have considerably restrained clinical application of QU. 13 Hence, a modification with bioactive molecules to mediate the brain distribution of QU can be a possible approach to alleviating AD progression.…”

Section: Introductionmentioning

confidence: 99%

Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin

Kuo

Tsao

2017

IJN

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A drug delivery system of quercetin (QU)-encapsulated liposomes (LS) grafted with RMP-7, a bradykinin analog, and lactoferrin (Lf) was developed to permeate the blood–brain barrier (BBB) and rescue degenerated neurons, acting as an Alzheimer’s disease (AD) pharmacotherapy. This colloidal formulation of QU-encapsulated LS grafted with RMP-7 and Lf (RMP-7-Lf-QU-LS) was used to traverse human brain microvascular endothelial cells (HBMECs) regulated by human astrocytes (HAs) and to treat SK-N-MC cells after an insult with cytotoxic β-amyloid (Aβ) fibrils. We found that surface RMP-7 and Lf enhanced the ability of QU to cross the BBB without inducing strong toxicity and damaging the tight junction. In addition, RMP-7-Lf-QU-LS significantly reduced Aβ-induced neurotoxicity and improved the viability of SK-N-MC cells. Compared with free QU, RMP-7-Lf-QU-LS could also significantly inhibit the expression of phosphorylated c-Jun N terminal kinase, phosphorylated p38, and phosphorylated tau protein at serine 202 by SK-N-MC cells, indicating an important role of RMP-7, Lf, and LS in protecting neurons against apoptosis. RMP-7-Lf-QU-LS is a promising carrier targeting the BBB to prevent Aβ-insulted neurodegeneration and may have potential in managing AD in future clinical applications.

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Section: Introductionmentioning

confidence: 99%

Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin

Kuo

Tsao

2017

IJN

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“…Increased ROS production exerts toxic effects on membrane polyansaturated phospholipids, resulting in generation of toxic products such as MDA (Arnal et al 2010). Diabetes, the most common endocrine disorder, characterized by increased blood glucose levels resulting from defective insulin secretion and its complications are associated with increased oxidative stress (Bhutada et al 2010;Amin et al 2015). In the STZ-induced diabetes, MDA levels increase Apaydın et al 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Pandır

Ünal

Baş

2016

Braz. arch. biol. technol.

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Furan is a food and environmental contaminant and a potent carcinogen in animals. Lycopene is one dietary carotenoid found in fruits such as tomato, watermelon and grapefruit. The present study was designed to explore the protective effect of lycopene against furan-induced oxidative damage in streptozotocin (STZ)-induced diabetic rat kidney. At the end of the experimental period (28 days), we found that lycopene markedly decreased the malondialdehide (MDA) levels in the kidney, urea, uric acid and creatinine levels in the serum of furan-treated rats. The increase of histopathology in the kidney of furan-treated rats were effectively suppressed by lycopene. Furthermore, lycopene markedly restored superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx) and glutathione-S-transferase (GST) activities in the kidney of furan-treated rats.In conclusion, these results suggested that lycopene could protect the rat kidney against furan-induced injury by improving renal function, attenuating histopathologic changes, reducing MDA production and renewing the activities of antioxidant enzymes.

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“…At 72 h following the STZ injection, blood samples were collected from the tail vein to measure blood glucose levels. Rats with fasting blood glucose levels >16.7 mmol/l were considered successful DM models and were used for further investigation (59). The normal rats who did not accept the treatment of STZ were randomly divided into two groups: The control group (treated with normal saline injection every day), and the H 2 S-c2 group (normal rats treated with a high concentration of NaHS, c2=100 µmol/kg; received i.p., daily).…”

Section: Methodsmentioning

confidence: 99%

Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model

Luo

et al. 2016

Molecular Medicine Reports

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Abstract. Endoplasmic reticulum (ER) stress is critical in the occurrence and development of diabetic cardiomyopathy (DC). Hydrogen sulfide (H 2 S) has been found to be the third gaseous signaling molecule with anti-ER stress effects. Previous studies have shown that H 2 S acts as a potent inhibitor of fibrosis in the heart of diabetic rats. This study aimed to demonstrate whether H 2 S exhibits protective effects on the myocardium of streptozotocin (STZ)-induced diabetic rats by suppressing ER stress. In this study, diabetic models were established by intraperitoneal (i.p.) injection of 40 mg/kg STZ. The STZ-treated mice were divided into three groups, and subsequently treated with normal saline, 30 µmol/kg or 100 µmol/kg NaHS, i.p., respectively, for 8 weeks. The extent of myocyte hypertrophy was measured using hematoxylin and eosin-stained sections and collagen components were investigated using immunostaining. The expression of glucose-regulated protein (Grp78), C/EBP-homologous protein (CHOP) and caspase-12 in the heart tissue of each group was detected by western blot analysis. It was demonstrated that H 2 S could improve myocardial hypertrophy and myocardial collagen deposition in diabetic rats. In addition, it could reduce the expression of Grp78, caspase-12 and CHOP. In conclusion, these findings demonstrate that H 2 S suppresses STZ-induced ER stress in the hearts of rats, and it may serve as a novel cardioprotective agent for DC.

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Ameliorative effect of quercetin on memory dysfunction in streptozotocin-induced diabetic rats

Cited by 142 publications

References 69 publications

Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin

Neuroprotection against apoptosis of SK-N-MC cells using RMP-7- and lactoferrin-grafted liposomes carrying quercetin

Lycopene Protects the Diabetic Rat Kidney Against Oxidative Stress-mediated Oxidative Damage Induced by Furan

Hydrogen sulfide exhibits cardioprotective effects by decreasing endoplasmic reticulum stress in a diabetic cardiomyopathy rat model

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