Ameliorative effect of tephrosia purpurea in arsenic-induced nephrotoxicity in rats

Gora, Ravuri Halley; Kerketta, Priscilla; Baxla, Sushma Lalita; Toppo, Reetu; Prasad, R.; Patra, Pabitra Hriday; Roy, B. K.

doi:10.4103/0971-6580.128807

Cited by 21 publications

(10 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These results show compatibility with the literature. It has been reported also in the previous studies that a reduction also occurred in levels of compounds with antioxidant characteristics such as selenium 37 and glutathione 38,39 as well as decreased antioxidant enzyme activities in the rat tissues exposed to arsenic. [39][40][41] Contrarily, it has been encountered in the arsenic + TQ group that tissue MDA level decreased, while a significant elevation was encountered in the antioxidant enzyme activities (SOD and CAT) when compared with the arsenic group.…”

Section: Discussionmentioning

confidence: 88%

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

et al. 2015

View full text Add to dashboard Cite

We aimed to investigate the protective role of thymoquinone (TQ) by targeting its antiapoptotic and antioxidant properties against kidney damage induced by arsenic in rats. We have used the 24 male Sprague-Dawley rats. Rats were divided into three groups. Physiological serum in 10 mL/kg dose as intragastric was given to the control group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) was given to the arsenic group. Sodium arsenite (10 mg/kg, intragastric by gavage for fifteen days) and TQ (10 mg/kg, intragastric by gavage for 15 days) was given to the arsenic + TQ group. After 15 days, the animals' kidneys were taken theirs, then we have performed histological and apoptotic assessment. Superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) enzyme activities and malondialdehyde (MDA) levels have examined as the oxidative stress parameters. We have determined the levels of arsenic. Increased renal injury and apoptotic cells have been detected in the arsenic group. Degenerative changes in the arsenic + TQ group were diminished. Although the MDA levels were augmented in the arsenic group, SOD, CAT and GSH-Px enzyme activities were lessened than the other groups. Our findings suggest that TQ may impede the oxidative stress, the cells have been damaged and also the generation of apoptotic cells arisen from arsenic. TQ plays a protective role against arsenic-induced toxicity in kidney and may potentially be used as a remedial agent.

show abstract

Section: Discussionmentioning

confidence: 88%

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

et al. 2015

View full text Add to dashboard Cite

show abstract

“…New nephrons in the kidney cortex margin, their maturity gained in a few days after birth. At this time, the amount of Ar that passes through breast milk is relatively insignificant ( 43 ). Zinc administration significantly effected on the progression of renal histopathological changes, which represents the antioxidant potential of Zinc.…”

Section: Discussionmentioning

confidence: 99%

Administration of zinc against arsenic-induced nephrotoxicity during gestation and lactation in rat model

et al. 2016

View full text Add to dashboard Cite

BackgroundFree radicals production by toxicity of arsenic (Ar) is most important in the nephrotoxicity. There is accumulating evidence that zinc (Zn), has anti-oxidant properties.ObjectivesThe aim of present study was to evaluate protective and ameliorative effects of Zn against Ar-induced nephrotoxicity in rat pups during gestation and lactation.Materials and MethodsTwenty-four adult pregnant wistar rats were randomly divided into four groups (n = 6). Group one was given vehicle only. Group two received Zn (ZnSO4) at 20 mg/kg/d. Group three received Ar at 5 mg/kg/d as sodium meta-arsenite. Group four received Ar + Zn at the same dose that mentioned in groups of two and three. At the end of the study, 24 hours after the last treatment, samples were killed with overdose of sodium pentobarbital and kidneys were harvested for measuring malondialdehyde (MDA), glutathione (GSH) and histopathological assessment.ResultsThe MDA level in kidney was increased in the Ar group, which was decreased after Zn administration in the Ar + Zn group. The GSH level in kidney was decreased in the Ar group, which were increased after Zn administration in the Ar + Zn group. Also, the histopathological changes which were detected in the Ar group attenuated after Zn consumption.ConclusionsOur findings suggested that administration of Zn during gestation and lactation could have protective and prevent effect in Ar-induced oxidative stress in kidney tissue.

show abstract

“…Numerous studies have investigated the protective effects of several agents on arsenic-induced damage. Oral treatment with tephrosia purpurea extract protected rats from arsenic-induced nephrotoxicity [ 31 ]. In addition, Juglans nigra showed hepatoprotective and anticlastogenic effects induced by arsenite [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB

et al. 2015

View full text Add to dashboard Cite

High concentrations of arsenic, which can be occasionally found in drinking water, have been recognized as a global health problem. Exposure to arsenic can disrupt spatial memory; however, the underlying mechanism remains unclear. In the present study, we tested whether exercise could interfere with the effect of arsenic exposure on the long-term memory (LTM) of object recognition in mice. Arsenic (0, 1, 3, and 10 mg/ kg, i.g.) was administered daily for 12 weeks. We found that arsenic at dosages of 1, 3, and 10 mg/kg decreased body weight and increased the arsenic content in the brain. The object recognition LTM (tested 24 h after training) was disrupted by 3 mg/ kg and 10 mg/ kg, but not 1 mg/ kg arsenic exposure. Swimming exercise also prevented LTM impairment induced by 3 mg/ kg, but not with 10 mg/ kg, of arsenic exposure. The expression of brain-derived neurotrophic factor (BDNF) and phosphorylated cAMP-response element binding protein (pCREB) in the CA1 and dentate gyrus areas (DG) of the dorsal hippocampus were decreased by 3 mg/ kg and 10 mg/ kg, but not by 1 mg/ kg, of arsenic exposure. The decrease in BDNF and pCREB in the CA1 and DG induced by 3 mg/ kg, but not 10 mg/ kg, of arsenic exposure were prevented by swimming exercise. Arsenic exposure did not affect the total CREB expression in the CA1 or DG. Taken together, these results indicated that swimming exercise prevented the impairment of object recognition LTM induced by arsenic exposure, which may be mediated by BDNF and CREB in the dorsal hippocampus.

show abstract

Ameliorative effect of tephrosia purpurea in arsenic-induced nephrotoxicity in rats

Cited by 21 publications

References 24 publications

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

Protective effects of thymoquinone against apoptosis and oxidative stress by arsenic in rat kidney

Administration of zinc against arsenic-induced nephrotoxicity during gestation and lactation in rat model

Exercise Prevents Memory Impairment Induced by Arsenic Exposure in Mice: Implication of Hippocampal BDNF and CREB

Contact Info

Product

Resources

About