Ameliorative effect of Trametes orientalis polysaccharide against immunosuppression and oxidative stress in cyclophosphamide-treated mice

Dietary Chlorella vulgaris Ameliorates Altered Immunomodulatory Functions in Cyclophosphamide-Induced Immunosuppressive Mice

“…There are some studies using Lactobacillus plantarum or Lactobacillus casei as an immunomodulator in CYP-treated mice [ 24 , 25 ], these probiotics had the potential ability to enhance intestine mucosa immunity. Also, with other dietary active ingredients such as polysaccharide [ 3 ] and Omega-3 fatty acids [ 26 ], all these dietary ingredients administration alleviate the immunosuppression and inflammation caused by CYP treatment to some extent. When compared with these nutrients, a few researches focused on the evaluation of the immunomodulatory effect of the whole food supplement on CYP induced toxicity.…”

“…Chemotherapeutic drugs have been widely used in the treatment of various malignancies and autoimmune diseases [ 1 ], but their therapeutic effectiveness is accompanied with some severely adverse side effects [ 2 ]. Cyclophosphamide (CYP) is an alkylating cytotoxic drug and has been applied in the therapy of several cancers and autoimmune disorders, such as rectum cancer, liver cancer, lymphoma, breast cancer and rheumatoid arthritis [ 3 ]. However, patients undergoing CYP therapy must face some severe adverse effects including immunosuppression and oxidative stress injuries [ 4 ].…”

In vivo immunoprotective role of Indigofera tinctoria and Scoparia dulcis aqueous extracts against chronic noise stress induced immune abnormalities in Wistar albino rats

“…Both of them play a vital role in lytic activity and killing the target cells [60] . In connection with that, polysaccharide isolated form Trametes orientalis enhanced the cytotoxicity of spleen NK cells under cyclophosphamide induced oxidative stress conditions [55] . Moreover, in previous study we found that physical or psychological stress decreased NK cells cytotoxicity and mRNA transcription of granzymes and perforin in mice [61] .…”

“…It plays a crucial role in the human and animal immune defense against cancer cell development, infectious and non infectious factor [54] . In previous study, Zheng et al [55] reported that the oxidative stress could be decreased the phagocytosis of macrophages in mice and the mice treated with polysaccharide of Trametes orientalis could enhance the phagocytosis. Similarly our study results also clearly demonstrate that both ITAE and SDAE are potentially stimulated the phagocytic response during noise induced oxidative stress condition.…”

Immunomodulatory activity of a novel polysaccharide from Lonicera japonica in immunosuppressed mice induced by cyclophosphamide

“…Hyriopsis cumingii polysaccharides could strengthen peritoneal macrophage expressing MR-1 and NF-κB in a dose-dependent manner [ 6 ]. In fact, several polysaccharides, such as Ginseng polysaccharides [ 7 ], Cheonggukjang polysaccharides, Trametes orientalis polysaccharide [ 8 ], Ganoderma atrum polysaccharide [ 9 ], have already been used clinically to enhance the body's immune function.…”