Ameliorative effects of sodium bentonite on phagocytosis and Newcastle disease antibody formation in broiler chickens during aflatoxicosis

Ibrahim, I. K. A.; Shareef, A. M.; Al-Joubory, K.M.T

doi:10.1053/rvsc.2000.0390

Cited by 56 publications

(36 citation statements)

References 17 publications

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“…As well, Manegar et al (2010) confirmed that aflatoxin causes bursal regression and suppress primary immune response for ND and Gumboro disease as evident by fall in ELISA titers. Enhancement of the humoral immune response after addition of binders like Humate or HSCAS in this investigation is in line with Ibrahim et al (2000) who citied that supplementation of sodium bentonite binder was significantly effective in ameliorating the negative effect of aflatoxin on the percentage and mean of phagocytosis and HI-titer in chicks vaccinated against ND. It has been reported that Humate significantly improve antibody levels in broiler chickens, fed graded levels of AF (Swamy and Devegowda, 1998), multiple mycotoxins (Raju and Devegowda, 2002) and also it inhibited lipid peroxidation in liver of quails fed T-2 toxin (Dvorska and Surai, 2001).…”

Section: Immune Response To Nd and Ibdsupporting

confidence: 86%

Evaluation of Antimycotoxin Effects of Humate and Hydrated Sodium Calcium Aluminosilicate on Broilers Toxicated with Aflatoxin

Tawfeek¹,

Hassan²,

Eid³

2017

AJVS

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Key words:aflatoxin, broiler, adsorbent compounds, detoxificationThe objective of this study was to investigate the protective effect of dietary natural sorbent-Humate (0.2%) and Hydrated sodium calcium aluminosilicate (HSCAS) (0.5%) on the prevention of aflatoxin (AF) toxicity in the broiler chicken 7-35 days of age. Two hundred and forty broiler chicks were randomly divided into four treatment groups of 4 replicates (each contained 15 chicks). While chicks in group 1 were fed a basal diet free of toxin (control), group 2 chicks were fed a basal diet contaminated with 1ppm AF, the other two groups 3 and 4 were fed contaminated basal diet supplemented with 0.2% Biofarm® Dry humate, and 0.5% HSCAS, respectively. Parameters evaluated were growth performance, some serum constituents, some organs weight, and immune response to Newcastle disease and infectious bursal disease. The results showed that, Aflatoxin (1 ppm/kg) significantly reduced feed intake, weight gain and feed efficiency. Further aflatoxin increased the relative weights of liver, kidney, gizzard and spleen, while the relative weights of thymus and bursa of Fabricius were decreased by AF. Aflatoxin toxin also reduced antibody titres against Newcastle disease and infectious bursal disease. Modified 0.2% Humate significantly (P ≤ 0.05) improved body weight, feed intake, decreased relative organ weights and improved antibody titres, bursa of Fabricius and thymus weights. Hydrated sodium calcium aluminosilicate (0.5%) showed improvement against AF. The results of our experiment showed that 0.2% Humate and 0.5% HSCAS has a positive effect on the growth of broilers. And it could have been a suitable natural supplement for growing broilers against the adverse effects of aflatoxins.

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Section: Immune Response To Nd and Ibdsupporting

confidence: 86%

Evaluation of Antimycotoxin Effects of Humate and Hydrated Sodium Calcium Aluminosilicate on Broilers Toxicated with Aflatoxin

Tawfeek¹,

Hassan²,

Eid³

2017

AJVS

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“…The beneficial effect of Mycofix® has been reported to ameliorate the negative effect of AF on IBDV antibody titres and the effects are attributed to the presence of phytogenic substances, a hepatoprotective flavolignins (silymarin) in Mycofix, which prevents toxins from entering the liver cell membranes, and as it contains the terpenoid complexes, which reduce inflammations and protect the mucous membranes (Biomin®, 2000). Similarly, Ibrahim et al, (2000) reported that SB is also effective in ameliorating the suppressive effect of AF on the HI-titer in chicks vaccinated against Newcastle disease and the best result was obtained when SB was added at a rate of 0.4% of feed to the AF-containing diets. This effect was attributed to the role of SB as a sequestering agent against AF present in the diet through reducing its bioavailability in the gastrointestinal tract (Araba and Wyatt, 1991).…”

Section: Antibody Titrementioning

confidence: 87%

“…Besides the preventive management, several approaches have been employed including physical (feed mill techniques, blending, extraction, irradiation, and heating), chemical (acids, bases, alkali treatments and oxidizing agents) biological treatments (certain species of fungi and bacteria) and solvent extraction to detoxify AF in contaminated feeds and feedstuffs (Coker et al, 1986;Piva et al, 1995;Parlat et al, 1999). Since the beginning of 1990s, the adsorbent-based studies have also been reported to be effective in removing AF from contaminated feed and minimise the toxicity of AF in poultry (Ibrahim et al, 2000). Among several adsorbents commercially available in the market, Zeolites (Miazzo et al, 2000), bentonites (Rosa et al, 2001, Pasha et al, 2007, 2008 and clinoptilolite (CLI), (Oguz and Kurtoglu, 2000;Oguz et al, 2000 a, b), were preferred because of their high binding capacities for AF and their reducing effect on AF-absorption from the gastrointestinal tract.…”

mentioning

confidence: 99%

Comparative Evaluation of Different Techniques for Aflatoxin Detoxification in Poultry Feed and Its Effect on Broiler Performance

Mahmood¹,

Pasha²,

Khattak³

2011

Aflatoxins - Detection, Measurement and Control

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“…In a five-week study on chickens for fattening, Manafi et al (2009) could show a reduction of the adverse effects of AfB 1 (500 µg/kg; significant reduction of body weight, feed consumption and antibody titres against Newcastle disease (ND) and Infectious Bursal Disease (IBD); increases in the relative liver weight) by 1 % bentonite in the diet. The adverse effects of aflatoxin (254 µg Af = 200 µg AfB 1 /kg diet) on antibody production against IBD were reduced by 0.5 % bentonite in the diet of chickens (254 µg Af = 200 µg AfB 1 /kg diet; Ghahri et al, 2009), on antibody production against ND by up to 0.6 % bentonite in the diet (2500 µg AF = 81 % AfB 1 /kg diet; Ibrahim et al, 2000). Eraslan et al (2005) observed that aflatoxin decreased calcium and phosphate levels in blood of chickens, which was less marked when bentonite at 0.25 or 0.5 % was added to the diet.…”

Section: Poultrymentioning

confidence: 99%

Scientific Opinion on the safety and efficacy of bentonite (dioctahedral montmorillonite) as feed additive for all species

2011

EFS2

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Bentonite (dioctahedral montmorillonite) is an additive proposed to be authorised as a substance for the reduction of the contamination of feed by mycotoxins for all animal species at a recommended use level ranging from 0.05 and 0.3 % in complete feed. The FEEDAP Panel considers 0.5 % bentonite as safe for all target animal species. Since (i) bentonite is authorised as food additive without any restriction, (ii) natural montmorillonite is not genotoxic, and (iii) a 28-week toxicity study in rats showed dietary levels up to 2 % calcium montmorillonite without toxicity, the FEEDAP Panel considers that there is no safety concern for consumers. Bentonite is not irritant to skin and mildly irritant to eyes. Bentonite airborne dust is associated with elevated susceptibility to pulmonary infections. Bentonite is ubiquitous in the environment and is not expected to adversely affect the environment. In vitro systems demonstrated the ability of bentonite to adsorb aflatoxins in aqueous media at different pH values and to a lower degree in gastric juice. Since in vitro systems do not completely mimic the complex situations during digestion, an efficacy assessment requires a minimum of in vivo data. Two in vivo studies in dairy cows (< 5 µg AfB 1 /kg feed) demonstrated a significant reduction in AfB 1 excretion via milk by 0.03-1 % bentonite. The FEEDAP Panel concluded that the bentonite under application has the potential to be efficacious as aflatoxin binder in feed of dairy cows, and extended this conclusion to all ruminants. The Panel was not in a position to assess the efficacy of the bentonite under application as aflatoxin binder for any other animal species than ruminants due to the absence of data. SUMMARYFollowing a request from of the European Commission, the Panel on Additives and Products or Substances used in Animal Feed (FEEDAP) was asked to deliver an opinion on the safety for the target animals, consumer, user and the environment and the efficacy of the product bentonite (dioctahedral montmorillonite). Bentonite is currently authorised as binder, anticaking and anticoagulant agent. The applicant is now seeking authorisation for bentonite as a substance for the reduction of the contamination of feed by mycotoxins, at a recommended use level ranging from 0.05 to 0.3 % in complete feed.Although no typical tolerance studies with bentonites were found in the literature, the varying bentonite levels (0.2-10 %) used in a multitude of studies (with poultry, ruminants and trout) allow performing an assessment of safety for the target animals. Levels of 1-2 % were tolerated if only zootechnical parameters were considered. However, already 0.5 % bentonite reduced the availability of the essential trace element manganese. Bentonites also interact with coccidiostats and other medicinal substances but apparently not with vitamins. The FEEDAP Panel considers, as a conservative estimate, 0.5 % bentonite to be safe for all target animal species.Since (i) bentonite is authorised as food additive without any restric...

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Ameliorative effects of sodium bentonite on phagocytosis and Newcastle disease antibody formation in broiler chickens during aflatoxicosis

Cited by 56 publications

References 17 publications

Evaluation of Antimycotoxin Effects of Humate and Hydrated Sodium Calcium Aluminosilicate on Broilers Toxicated with Aflatoxin

Evaluation of Antimycotoxin Effects of Humate and Hydrated Sodium Calcium Aluminosilicate on Broilers Toxicated with Aflatoxin

Comparative Evaluation of Different Techniques for Aflatoxin Detoxification in Poultry Feed and Its Effect on Broiler Performance

Scientific Opinion on the safety and efficacy of bentonite (dioctahedral montmorillonite) as feed additive for all species

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