Ameliorative Impacts of &lt;i&gt;Tribulus terrestris&lt;/i&gt; Against Ivermectin-Induced Hepato-Renal Toxicity in Rabbit: Pharmacological and Histopathological Study

Ismaiel, Sally I.; Farouk, Sameh Mohamed; El-Ramady, R.A.; Khalil, Waleed F.

doi:10.3844/ajavsp.2017.8.16

Cited by 5 publications

(1 citation statement)

References 30 publications

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“…E/Se against it. Both IVM and DME revealed a non-significant increment in the red blood cells (RBCs), platelet count and Hb concentration compared to the control (Ismaiel et al 2017). On the other hand, treatment with IVM or DME tended to significantly increase the white blood cell (WBC) count when compared to the control.…”

Section: Discussionmentioning

confidence: 88%

Co-administration of vitamin E and selenium in vivo and in vitro ameliorates the toxic effects caused by ivermection and doramectin

Ahmed¹,

Al-Kahtani²,

Khalil³

et al. 2020

Vet. Med. - Czech

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Avermectins are used in animals and humans for their broad-spectrum effects against parasites causing cytotoxicity and damage to the cellular DNA. In this study, we examined the toxicological changes of ivermectin (IVM) and doramectin (DME) with or without the co-administration of vitamin E (Vit. E) and selenium (Se). The drugs used were for animal use. Twenty-five adult male rats were divided into five groups. Group 1 (control) was given saline, Group 2 was given IVM (0.2 mg/kg b.w.), Group 3 was given IVM and Vit. E/Se (80/1.6 mg/kg b.w., respectively), Group 4 received DME (0.2 mg/kg b.w.), and Group 5 received DME and Vitamin E/Se. Both IVM and DME were given by subcutaneous injections whereas Vit. E and Se were given orally. All the treatments were given once per week throughout the eight weeks. Although the doses were off-label use, they were given in a long-term course to unveil their toxicity effects in a clear manner and the response of the amelioration. By 24-h after the 8th week, the rats were sacrificed. Their blood was sampled for the haematological and serobiochemical examinations. Histopathological changes and caspase-3 were determined in the hepatic and renal tissues. The histopathological findings showed that Vit. E and Se reduced the cellular changes induced by IVM or DME, indicating that Vit. E and Se protect against both types of avermectins, and that DME was safer than IVM. The cytotoxicity was assessed on a human embryo kidney (HEK) and skin cells by the SRB/IC50 method and AO/EB (acridine orange-ethidium bromide) staining. Both IVM and DME caused apoptosis in the cultured HEK more than in the skin cells (80% vs. 30%, respectively). The cellular apoptosis in response to the IVM was more than that of DME, and the use of Vit. E and Se reduced the cytotoxicity as observed by caspase-3, in vivo, and IC50, in vitro.

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Section: Discussionmentioning

confidence: 88%

Co-administration of vitamin E and selenium in vivo and in vitro ameliorates the toxic effects caused by ivermection and doramectin

Ahmed¹,

Al-Kahtani²,

Khalil³

et al. 2020

Vet. Med. - Czech

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Comparative immuno-modulatory effects of basil and sesame seed oils against diazinon-induced toxicity in rats; a focus on TNF-α immunolocalization

Farouk

Gad

Emam

2020

Environ Sci Pollut Res

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Comparative immunomodulatory efficacy of rosemary and fenugreek against Escherichia coli infection via suppression of inflammation and oxidative stress in broilers

Farouk

Abdel-Rahman

Abdallah

et al. 2022

Environ Sci Pollut Res

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Broilers are frequently infected with Escherichia coli (E.Coli) bacteria, which often leads to the emergence of many diseases and high economic losses. Hence, the present study was performed to assess the comparative e cacy of dietary rosemary and fenugreek, under E.Coli-infection in broilers, via evaluation of growth performance, biochemical indices, immunological response and histo-morphological changes.Eighty Cobb broilers were allotted to four equal groups (n=20 chicks/group); control non-infected (CN), control infected (CI), rosemary infected (RI) and fenugreek infected (FI) groups. RI and FI groups showed a signi cant elevation in their body weight and body weight gain compared with CI group. Moreover, both groups revealed a signi cant decline in serum aspartate and alanine aminotransferase activities, as well as uric acid and creatinine levels. Signi cant decreases of total antioxidant capacity, catalase and superoxide dismutase activities were noted among CI chicks. Moreover, distinctly higher levels were evident in both RI and FI groups. Immunomodulatory markers assessment showed a signi cant increase in immunoglobulin G with a signi cant decline in interleukin-6 level in both RI and FI groups, with the lowest IL-6 value within FI group. Histopathological evaluations focused on the deleterious effect associated with E-Coli infection of broilers' liver, kidney, intestine, spleen, bursa of fabricius, and thymus. A partial histological improvement was noticed among RI group, and nearly normal tissues were recorded in FI group. Overall, these ndings suggest the ability of fenugreek to mitigate the adverse effects of E.Coli-infection on broiler performance and tissue pictures, through improvement of the chicken general health condition.

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Ameliorative Impacts of <i>Tribulus terrestris</i> Against Ivermectin-Induced Hepato-Renal Toxicity in Rabbit: Pharmacological and Histopathological Study

Cited by 5 publications

References 30 publications

Co-administration of vitamin E and selenium in vivo and in vitro ameliorates the toxic effects caused by ivermection and doramectin

Co-administration of vitamin E and selenium in vivo and in vitro ameliorates the toxic effects caused by ivermection and doramectin

Comparative immuno-modulatory effects of basil and sesame seed oils against diazinon-induced toxicity in rats; a focus on TNF-α immunolocalization

Comparative immunomodulatory efficacy of rosemary and fenugreek against Escherichia coli infection via suppression of inflammation and oxidative stress in broilers

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