Ameliorative potential of Butea monosperma on chronic constriction injury of sciatic nerve induced neuropathic pain in rats

Abstract

The present study was designed to investigate the ameliorative role of ethanolic extract from leaves of Butea monosperma in chronic constriction injury (CCI) of sciatic nerve induced neuropathic pain in rats. Hot plate, acetone drop, paw pressure, Von Frey hair and tail immersion tests were performed to assess the degree of thermal hyperalgesia, cold chemical allodynia, mechanical hyperalgesia & allodynia in the left hind paw and tail thermal hyperalgesia. Further on, thiobarbituric acid reactive substances (TBARS), reduced glutathione (GSH) and total calcium levels were estimated to assess the biochemical changes in the sciatic nerve tissue. Histopathological changes were also observed in the sciatic nerve tissue. Ethanolic extract of Butea monosperma leaves and pregabalin (serving as positive control) were administered for 14 consecutive days starting from the day of surgery. CCI resulted in significant changes in behavioural and biochemical parameters. Pretreatment of Butea monosperma attenuated CCI induced development of behavioural, biochemical and histopathological alterations in a dose dependent manner, which is comparable to that of pregabalin pretreated group. These findings may be attributed to its potential anti-oxidative, neuroprotective and calcium channel modulatory actions of Butea monosperma.

Hydroalcoholic extract of red propolis promotes functional recovery and axon repair after sciatic nerve injury in rats

“…In this study, HERP attenuated the behavioural and histological changes induced by sciatic nerve crush injury. The axonal growth associated with functional recovery was observed after SNI using natural products and flavonoids (Thiagarajan et al 2002;Quintans et al 2014). These actions are frequently attributed to their antioxidant and anti-inflammatory activities because the influence of the microenvironment (oxidative potential, presence of inflammatory and glial cells, and altered calcium levels) in upholding or reducing the overall regeneration of peripheral nerves has been found to be essential (Muthuraman and Singh 2012;Kou et al 2013;Tufek et al 2013).…”

“…(Fabaceae) extract promoted behavioural, biochemical, and histological changes in animals with sciatic nerve injuries. These results were mainly attributed to the antioxidant and anti-inflammatory properties of the extracts (Thiagarajan et al 2002). Thus, the use of natural products as pharmacological agents appears to be a promising approach for modulating local inflammation and avoiding secondary damage, which may improve the regeneration process (Tamaddonfard et al 2013).…”

Structure-Activity Relationship and Mechanistic Insights for Anti-HIV Natural Products

“…Chrysoeriol is separated from Eurya ciliate, has used for anti-HIV activity [369]. Diospyros mespiliformis Ebenaceae Bark [382] Alternanthera brasiliana Amaranthaceae Roots [383] Ricinus communis Euphorbiaceae Leaves [384] Butea monosperma Fabaceae Roots [385] Prosopis glandulosa Fabaceae Leaves [386] Sophora tonkinensis Fabaceae Roots [387] Gunnera magellanica Gunneraceae Stem [388] Swertia franchetiana Gentianaceae Roots [389] Curcuma longa Zingiberaceae Rhizomes [390] Stewartia koreana Theaceae Leaves [391] Cissus quadrangularis Vitaceae Stems [392] Withania somnifera…”

An experimetal evaluation of nephroprotective potential of Butea monosperma extract in albino rats

“…The plant is known for antioxidant,[5] anti-obesity,[6] anticancer, and chemoprotective[7] potential. It is also useful against neuropathic[8] and peripheral pain. [9] The plant is also known for hepatoprotective and antidiabetic potential.…”